Improvement of the Dissolution Rate of Poorly Soluble Drugs by Solid Crystal Suspensions

We present a novel extrusion based approach where the dissolution rate of poorly soluble drugs (griseofulvin, phenytoin and spironolactone) is significantly accelerated. The drug and highly soluble mannitol are coprocessed in a hot melt extrusion operation. The obtained product is an intimate mixtur...

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Veröffentlicht in:	Molecular pharmaceutics 2011-06, Vol.8 (3), p.727-735
Hauptverfasser:	Thommes, Markus, Ely, David R, Carvajal, M. Teresa, Pinal, Rodolfo
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Stability Pharmaceutical Preparations - chemistry Solubility Suspensions - chemistry Temperature
Online-Zugang:	Volltext
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