High-Efficiency Molecular Counting in Solution:  Single-Molecule Detection in Electrodynamically Focused Microdroplet Streams

We report fluorescence detection of individual rhodamine 6G molecules using a linear quadrupole to focus streams of microdroplets through the waist of a counterpropagating cw Ar+ laser. Since the terminal velocity scales as the square of the droplet diameter, the droplet−laser interaction time was “...

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