Sex Differences in Early Carotid Atherosclerosis (from the Community-Based Gutenberg-Heart Study)
The objectives of this study were to describe gender differences in intima-media thickness (IMT) in a community-based population study and to define normal IMT values for healthy men and women. In total, 4,814 participants (aged 35 to 74 years; 2,433 men, 2,381 women) from the Gutenberg-Heart Study...
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| Veröffentlicht in: | The American journal of cardiology 2011-06, Vol.107 (12), p.1841-1847 |
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| container_title | The American journal of cardiology |
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| creator | Sinning, Christoph, MD Wild, Philip S., MD Echevarria, Francisco M. Ojeda, PhD Wilde, Sandra, BA Schnabel, Renate, MD Lubos, Edith, MD Herkenhoff, Stephanie Bickel, Christoph, MD Klimpe, Sven, MD Gori, Tommaso, MD, PhD Münzel, Thomas F., MD Blankenberg, Stefan, MD Espinola-Klein, Christine, MD |
| description | The objectives of this study were to describe gender differences in intima-media thickness (IMT) in a community-based population study and to define normal IMT values for healthy men and women. In total, 4,814 participants (aged 35 to 74 years; 2,433 men, 2,381 women) from the Gutenberg-Heart Study (GHS) were included. IMT was measured at both common carotid arteries using an edge detection system. Median IMT was 0.62 mm (25th percentile 0.55, 75th percentile 0.70) in women and 0.65 mm (25th percentile 0.57, 75th percentile 0.75) in men and was significantly associated with age (p 95th percentile was defined as abnormal. In this subgroup, gender differences in IMT became nonsignificant at older ages. At the age of 35 years, IMT was 0.71 mm in men and 0.61 mm in women at the 95th percentile. In comparison, at the age of 74 years, IMT at the 95th percentile was 0.90 mm in men and 0.89 mm in women. In conclusion, men had higher carotid IMT than women, but predictors of early carotid atherosclerosis were similar across genders. In young subjects without cardiovascular risk factors, normal values for IMT were lower in women compared with men. In contrast, in older subjects, gender differences in IMT became nonsignificant. |
| doi_str_mv | 10.1016/j.amjcard.2011.02.318 |
| format | Article |
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Ojeda, PhD ; Wilde, Sandra, BA ; Schnabel, Renate, MD ; Lubos, Edith, MD ; Herkenhoff, Stephanie ; Bickel, Christoph, MD ; Klimpe, Sven, MD ; Gori, Tommaso, MD, PhD ; Münzel, Thomas F., MD ; Blankenberg, Stefan, MD ; Espinola-Klein, Christine, MD</creator><creatorcontrib>Sinning, Christoph, MD ; Wild, Philip S., MD ; Echevarria, Francisco M. Ojeda, PhD ; Wilde, Sandra, BA ; Schnabel, Renate, MD ; Lubos, Edith, MD ; Herkenhoff, Stephanie ; Bickel, Christoph, MD ; Klimpe, Sven, MD ; Gori, Tommaso, MD, PhD ; Münzel, Thomas F., MD ; Blankenberg, Stefan, MD ; Espinola-Klein, Christine, MD ; Gutenberg-Heart Study</creatorcontrib><description>The objectives of this study were to describe gender differences in intima-media thickness (IMT) in a community-based population study and to define normal IMT values for healthy men and women. In total, 4,814 participants (aged 35 to 74 years; 2,433 men, 2,381 women) from the Gutenberg-Heart Study (GHS) were included. IMT was measured at both common carotid arteries using an edge detection system. Median IMT was 0.62 mm (25th percentile 0.55, 75th percentile 0.70) in women and 0.65 mm (25th percentile 0.57, 75th percentile 0.75) in men and was significantly associated with age (p <0.0001). On multivariate analysis, advanced age, smoking, and arterial hypertension were positively associated with higher IMT in men and women. A subgroup of 1,025 subjects without cardiovascular risk factors or previous cardiovascular disease was analyzed to define normal IMT values. Nomograms were calculated according to age and gender. For each age group, IMT >95th percentile was defined as abnormal. In this subgroup, gender differences in IMT became nonsignificant at older ages. At the age of 35 years, IMT was 0.71 mm in men and 0.61 mm in women at the 95th percentile. In comparison, at the age of 74 years, IMT at the 95th percentile was 0.90 mm in men and 0.89 mm in women. In conclusion, men had higher carotid IMT than women, but predictors of early carotid atherosclerosis were similar across genders. In young subjects without cardiovascular risk factors, normal values for IMT were lower in women compared with men. In contrast, in older subjects, gender differences in IMT became nonsignificant.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2011.02.318</identifier><identifier>PMID: 21481827</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Carotid Artery Diseases - pathology ; Carotid Artery, Common - pathology ; Female ; Gender differences ; Humans ; Male ; Medical sciences ; Middle Aged ; Risk Factors ; Sex Characteristics ; Studies ; Tunica Intima - pathology ; Tunica Media - pathology ; Veins & arteries</subject><ispartof>The American journal of cardiology, 2011-06, Vol.107 (12), p.1841-1847</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Sequoia S.A. 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Ojeda, PhD</creatorcontrib><creatorcontrib>Wilde, Sandra, BA</creatorcontrib><creatorcontrib>Schnabel, Renate, MD</creatorcontrib><creatorcontrib>Lubos, Edith, MD</creatorcontrib><creatorcontrib>Herkenhoff, Stephanie</creatorcontrib><creatorcontrib>Bickel, Christoph, MD</creatorcontrib><creatorcontrib>Klimpe, Sven, MD</creatorcontrib><creatorcontrib>Gori, Tommaso, MD, PhD</creatorcontrib><creatorcontrib>Münzel, Thomas F., MD</creatorcontrib><creatorcontrib>Blankenberg, Stefan, MD</creatorcontrib><creatorcontrib>Espinola-Klein, Christine, MD</creatorcontrib><creatorcontrib>Gutenberg-Heart Study</creatorcontrib><title>Sex Differences in Early Carotid Atherosclerosis (from the Community-Based Gutenberg-Heart Study)</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The objectives of this study were to describe gender differences in intima-media thickness (IMT) in a community-based population study and to define normal IMT values for healthy men and women. In total, 4,814 participants (aged 35 to 74 years; 2,433 men, 2,381 women) from the Gutenberg-Heart Study (GHS) were included. IMT was measured at both common carotid arteries using an edge detection system. Median IMT was 0.62 mm (25th percentile 0.55, 75th percentile 0.70) in women and 0.65 mm (25th percentile 0.57, 75th percentile 0.75) in men and was significantly associated with age (p <0.0001). On multivariate analysis, advanced age, smoking, and arterial hypertension were positively associated with higher IMT in men and women. A subgroup of 1,025 subjects without cardiovascular risk factors or previous cardiovascular disease was analyzed to define normal IMT values. Nomograms were calculated according to age and gender. For each age group, IMT >95th percentile was defined as abnormal. In this subgroup, gender differences in IMT became nonsignificant at older ages. At the age of 35 years, IMT was 0.71 mm in men and 0.61 mm in women at the 95th percentile. In comparison, at the age of 74 years, IMT at the 95th percentile was 0.90 mm in men and 0.89 mm in women. In conclusion, men had higher carotid IMT than women, but predictors of early carotid atherosclerosis were similar across genders. In young subjects without cardiovascular risk factors, normal values for IMT were lower in women compared with men. In contrast, in older subjects, gender differences in IMT became nonsignificant.</description><subject>Adult</subject><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology</subject><subject>Cardiology. 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Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Carotid Artery Diseases - pathology</topic><topic>Carotid Artery, Common - pathology</topic><topic>Female</topic><topic>Gender differences</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Sex Characteristics</topic><topic>Studies</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - pathology</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sinning, Christoph, MD</creatorcontrib><creatorcontrib>Wild, Philip S., MD</creatorcontrib><creatorcontrib>Echevarria, Francisco M. 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Ojeda, PhD</au><au>Wilde, Sandra, BA</au><au>Schnabel, Renate, MD</au><au>Lubos, Edith, MD</au><au>Herkenhoff, Stephanie</au><au>Bickel, Christoph, MD</au><au>Klimpe, Sven, MD</au><au>Gori, Tommaso, MD, PhD</au><au>Münzel, Thomas F., MD</au><au>Blankenberg, Stefan, MD</au><au>Espinola-Klein, Christine, MD</au><aucorp>Gutenberg-Heart Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex Differences in Early Carotid Atherosclerosis (from the Community-Based Gutenberg-Heart Study)</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2011-06-15</date><risdate>2011</risdate><volume>107</volume><issue>12</issue><spage>1841</spage><epage>1847</epage><pages>1841-1847</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The objectives of this study were to describe gender differences in intima-media thickness (IMT) in a community-based population study and to define normal IMT values for healthy men and women. In total, 4,814 participants (aged 35 to 74 years; 2,433 men, 2,381 women) from the Gutenberg-Heart Study (GHS) were included. IMT was measured at both common carotid arteries using an edge detection system. Median IMT was 0.62 mm (25th percentile 0.55, 75th percentile 0.70) in women and 0.65 mm (25th percentile 0.57, 75th percentile 0.75) in men and was significantly associated with age (p <0.0001). On multivariate analysis, advanced age, smoking, and arterial hypertension were positively associated with higher IMT in men and women. A subgroup of 1,025 subjects without cardiovascular risk factors or previous cardiovascular disease was analyzed to define normal IMT values. Nomograms were calculated according to age and gender. For each age group, IMT >95th percentile was defined as abnormal. In this subgroup, gender differences in IMT became nonsignificant at older ages. At the age of 35 years, IMT was 0.71 mm in men and 0.61 mm in women at the 95th percentile. In comparison, at the age of 74 years, IMT at the 95th percentile was 0.90 mm in men and 0.89 mm in women. In conclusion, men had higher carotid IMT than women, but predictors of early carotid atherosclerosis were similar across genders. In young subjects without cardiovascular risk factors, normal values for IMT were lower in women compared with men. In contrast, in older subjects, gender differences in IMT became nonsignificant.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21481827</pmid><doi>10.1016/j.amjcard.2011.02.318</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Carotid Artery Diseases - pathology Carotid Artery, Common - pathology Female Gender differences Humans Male Medical sciences Middle Aged Risk Factors Sex Characteristics Studies Tunica Intima - pathology Tunica Media - pathology Veins & arteries |
| title | Sex Differences in Early Carotid Atherosclerosis (from the Community-Based Gutenberg-Heart Study) |
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