Emergence of keratin 17 vs. loss of keratin 13: Their reciprocal immunohistochemical profiles in oral carcinoma in situ
Summary To evaluate differential expressions for keratin (K) subtypes 13 and 17 in oral borderline malignancies, we examined 67 surgical specimens of the oral mucosa for their immunohistochemical profiles. From those specimens, 173 foci of epithelial dysplasia, 152 foci of carcinoma in situ (CIS), a...
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| Veröffentlicht in: | Oral oncology 2011-06, Vol.47 (6), p.497-503 |
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| creator | Mikami, Toshihiko Cheng, Jun Maruyama, Satoshi Kobayashi, Takanori Funayama, Akinori Yamazaki, Manabu Adeola, Henry A Wu, Lanyan Shingaki, Susumu Saito, Chikara Saku, Takashi |
| description | Summary To evaluate differential expressions for keratin (K) subtypes 13 and 17 in oral borderline malignancies, we examined 67 surgical specimens of the oral mucosa for their immunohistochemical profiles. From those specimens, 173 foci of epithelial dysplasia, 152 foci of carcinoma in situ (CIS), and 82 foci of squamous cell carcinoma (SCC) were selected according to our diagnostic criteria, along with 20 areas of normal epithelia. In normal epithelia, there was no K17 positivity (0%), whereas definite K13 positivity (100%) was observed. The same tendencies were obtained in mild (undefined) and moderate (true) epithelial dysplasias (K17: 0%; K13: 100%). In contrast, all CIS (100%) had K17 positivities, while K13 positivities were lost in many of them (7%). Similar tendencies were confirmed in invasive SCC (K17: 100%, K13: 4%). Simultaneous immunopositivities for K17 and K13 were found only in SCC (7%) and CIS (4%) foci with distinct keratinization. These foci also showed K10 positivities, though K10 positive areas were not identical to K13 positive areas. The results indicate that expressions of K17 and K13 are reciprocal in oral epithelial lesions and that the K17 emergence is related to malignancies. |
| doi_str_mv | 10.1016/j.oraloncology.2011.03.015 |
| format | Article |
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From those specimens, 173 foci of epithelial dysplasia, 152 foci of carcinoma in situ (CIS), and 82 foci of squamous cell carcinoma (SCC) were selected according to our diagnostic criteria, along with 20 areas of normal epithelia. In normal epithelia, there was no K17 positivity (0%), whereas definite K13 positivity (100%) was observed. The same tendencies were obtained in mild (undefined) and moderate (true) epithelial dysplasias (K17: 0%; K13: 100%). In contrast, all CIS (100%) had K17 positivities, while K13 positivities were lost in many of them (7%). Similar tendencies were confirmed in invasive SCC (K17: 100%, K13: 4%). Simultaneous immunopositivities for K17 and K13 were found only in SCC (7%) and CIS (4%) foci with distinct keratinization. These foci also showed K10 positivities, though K10 positive areas were not identical to K13 positive areas. The results indicate that expressions of K17 and K13 are reciprocal in oral epithelial lesions and that the K17 emergence is related to malignancies.</description><identifier>ISSN: 1368-8375</identifier><identifier>EISSN: 1879-0593</identifier><identifier>DOI: 10.1016/j.oraloncology.2011.03.015</identifier><identifier>PMID: 21489858</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Carcinoma in situ ; Carcinoma in Situ - metabolism ; Carcinoma in Situ - pathology ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Epithelial dysplasia ; Epithelium - pathology ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Keratin 13 ; Keratin 17 ; Keratin-13 - metabolism ; Keratin-17 - metabolism ; Medical sciences ; Mouth Mucosa - metabolism ; Mouth Mucosa - pathology ; Oral mucosa ; Otolaryngology ; Otorhinolaryngology. Stomatology ; Precancerous Conditions - metabolism ; Precancerous Conditions - pathology ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Oral oncology, 2011-06, Vol.47 (6), p.497-503</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-bb17e3718b0600b0290d698edb35cc427d4962317e02d2d67fc78d1eae837c343</citedby><cites>FETCH-LOGICAL-c464t-bb17e3718b0600b0290d698edb35cc427d4962317e02d2d67fc78d1eae837c343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.oraloncology.2011.03.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24272681$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21489858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mikami, Toshihiko</creatorcontrib><creatorcontrib>Cheng, Jun</creatorcontrib><creatorcontrib>Maruyama, Satoshi</creatorcontrib><creatorcontrib>Kobayashi, Takanori</creatorcontrib><creatorcontrib>Funayama, Akinori</creatorcontrib><creatorcontrib>Yamazaki, Manabu</creatorcontrib><creatorcontrib>Adeola, Henry A</creatorcontrib><creatorcontrib>Wu, Lanyan</creatorcontrib><creatorcontrib>Shingaki, Susumu</creatorcontrib><creatorcontrib>Saito, Chikara</creatorcontrib><creatorcontrib>Saku, Takashi</creatorcontrib><title>Emergence of keratin 17 vs. loss of keratin 13: Their reciprocal immunohistochemical profiles in oral carcinoma in situ</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description>Summary To evaluate differential expressions for keratin (K) subtypes 13 and 17 in oral borderline malignancies, we examined 67 surgical specimens of the oral mucosa for their immunohistochemical profiles. From those specimens, 173 foci of epithelial dysplasia, 152 foci of carcinoma in situ (CIS), and 82 foci of squamous cell carcinoma (SCC) were selected according to our diagnostic criteria, along with 20 areas of normal epithelia. In normal epithelia, there was no K17 positivity (0%), whereas definite K13 positivity (100%) was observed. The same tendencies were obtained in mild (undefined) and moderate (true) epithelial dysplasias (K17: 0%; K13: 100%). In contrast, all CIS (100%) had K17 positivities, while K13 positivities were lost in many of them (7%). Similar tendencies were confirmed in invasive SCC (K17: 100%, K13: 4%). Simultaneous immunopositivities for K17 and K13 were found only in SCC (7%) and CIS (4%) foci with distinct keratinization. These foci also showed K10 positivities, though K10 positive areas were not identical to K13 positive areas. The results indicate that expressions of K17 and K13 are reciprocal in oral epithelial lesions and that the K17 emergence is related to malignancies.</description><subject>Biological and medical sciences</subject><subject>Carcinoma in situ</subject><subject>Carcinoma in Situ - metabolism</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Epithelial dysplasia</subject><subject>Epithelium - pathology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratin 13</subject><subject>Keratin 17</subject><subject>Keratin-13 - metabolism</subject><subject>Keratin-17 - metabolism</subject><subject>Medical sciences</subject><subject>Mouth Mucosa - metabolism</subject><subject>Mouth Mucosa - pathology</subject><subject>Oral mucosa</subject><subject>Otolaryngology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Precancerous Conditions - metabolism</subject><subject>Precancerous Conditions - pathology</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQQCNERUvhLyALCXFKOhPHsdMDEioFKlXiQDlbjjPpepvExU6K9t_jaJePcuJka_xmPPPsLHuNUCBgfbYtfDCDn6wf_O2uKAGxAF4AiifZCSrZ5CAa_jTtea1yxaU4zp7HuAUAgQKeZcclVqpRQp1kPy5HCrc0WWK-Z3cUzOwmhpI9xIINPsZHYX7ObjbkAgtk3X3w1gzMjeMy-Y2Ls7cbGt0aS0e9GyiylLT2yqwJ1k1-NGskunl5kR31Zoj08rCeZt8-Xt5cfM6vv3y6unh_nduqrua8bVESl6haqAFaKBvo6kZR13JhbVXKrmrqkicIyq7satlbqTokQ2lsyyt-mr3d100tfV8oznp00dIwmIn8ErWSIKpaCEjk-Z60IY0dqNf3wY0m7DSCXr3rrf7bu169a-A6eU_Jrw7XLO1I3e_UX6IT8OYAmJgM9cFM1sU_XBqlrBUm7sOeoyTlwVHQ0br1eTqXnM-68-7_-nn3Txk7uGl9mzvaUdz6JUxJu0YdSw366_pT1o-CCKkKVvwnfgi9ZA</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Mikami, Toshihiko</creator><creator>Cheng, Jun</creator><creator>Maruyama, Satoshi</creator><creator>Kobayashi, Takanori</creator><creator>Funayama, Akinori</creator><creator>Yamazaki, Manabu</creator><creator>Adeola, Henry A</creator><creator>Wu, Lanyan</creator><creator>Shingaki, Susumu</creator><creator>Saito, Chikara</creator><creator>Saku, Takashi</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Emergence of keratin 17 vs. loss of keratin 13: Their reciprocal immunohistochemical profiles in oral carcinoma in situ</title><author>Mikami, Toshihiko ; Cheng, Jun ; Maruyama, Satoshi ; Kobayashi, Takanori ; Funayama, Akinori ; Yamazaki, Manabu ; Adeola, Henry A ; Wu, Lanyan ; Shingaki, Susumu ; Saito, Chikara ; Saku, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-bb17e3718b0600b0290d698edb35cc427d4962317e02d2d67fc78d1eae837c343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma in situ</topic><topic>Carcinoma in Situ - metabolism</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Epithelial dysplasia</topic><topic>Epithelium - pathology</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratin 13</topic><topic>Keratin 17</topic><topic>Keratin-13 - metabolism</topic><topic>Keratin-17 - metabolism</topic><topic>Medical sciences</topic><topic>Mouth Mucosa - metabolism</topic><topic>Mouth Mucosa - pathology</topic><topic>Oral mucosa</topic><topic>Otolaryngology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Precancerous Conditions - metabolism</topic><topic>Precancerous Conditions - pathology</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mikami, Toshihiko</creatorcontrib><creatorcontrib>Cheng, Jun</creatorcontrib><creatorcontrib>Maruyama, Satoshi</creatorcontrib><creatorcontrib>Kobayashi, Takanori</creatorcontrib><creatorcontrib>Funayama, Akinori</creatorcontrib><creatorcontrib>Yamazaki, Manabu</creatorcontrib><creatorcontrib>Adeola, Henry A</creatorcontrib><creatorcontrib>Wu, Lanyan</creatorcontrib><creatorcontrib>Shingaki, Susumu</creatorcontrib><creatorcontrib>Saito, Chikara</creatorcontrib><creatorcontrib>Saku, Takashi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mikami, Toshihiko</au><au>Cheng, Jun</au><au>Maruyama, Satoshi</au><au>Kobayashi, Takanori</au><au>Funayama, Akinori</au><au>Yamazaki, Manabu</au><au>Adeola, Henry A</au><au>Wu, Lanyan</au><au>Shingaki, Susumu</au><au>Saito, Chikara</au><au>Saku, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emergence of keratin 17 vs. loss of keratin 13: Their reciprocal immunohistochemical profiles in oral carcinoma in situ</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>47</volume><issue>6</issue><spage>497</spage><epage>503</epage><pages>497-503</pages><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract>Summary To evaluate differential expressions for keratin (K) subtypes 13 and 17 in oral borderline malignancies, we examined 67 surgical specimens of the oral mucosa for their immunohistochemical profiles. From those specimens, 173 foci of epithelial dysplasia, 152 foci of carcinoma in situ (CIS), and 82 foci of squamous cell carcinoma (SCC) were selected according to our diagnostic criteria, along with 20 areas of normal epithelia. In normal epithelia, there was no K17 positivity (0%), whereas definite K13 positivity (100%) was observed. The same tendencies were obtained in mild (undefined) and moderate (true) epithelial dysplasias (K17: 0%; K13: 100%). In contrast, all CIS (100%) had K17 positivities, while K13 positivities were lost in many of them (7%). Similar tendencies were confirmed in invasive SCC (K17: 100%, K13: 4%). Simultaneous immunopositivities for K17 and K13 were found only in SCC (7%) and CIS (4%) foci with distinct keratinization. These foci also showed K10 positivities, though K10 positive areas were not identical to K13 positive areas. The results indicate that expressions of K17 and K13 are reciprocal in oral epithelial lesions and that the K17 emergence is related to malignancies.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21489858</pmid><doi>10.1016/j.oraloncology.2011.03.015</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Carcinoma in situ Carcinoma in Situ - metabolism Carcinoma in Situ - pathology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Epithelial dysplasia Epithelium - pathology Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Keratin 13 Keratin 17 Keratin-13 - metabolism Keratin-17 - metabolism Medical sciences Mouth Mucosa - metabolism Mouth Mucosa - pathology Oral mucosa Otolaryngology Otorhinolaryngology. Stomatology Precancerous Conditions - metabolism Precancerous Conditions - pathology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Emergence of keratin 17 vs. loss of keratin 13: Their reciprocal immunohistochemical profiles in oral carcinoma in situ |
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