Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production

Discoidin domain receptor (DDR)1 is an extracellular matrix (ECM)-sensing receptor tyrosine kinase, which is activated by collagen and expressed in bronchial epithelium. DDR1 is responsible for maintaining the normal structure of skin and kidney epithelia and we hypothesised that DDR1 plays a regula...

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Veröffentlicht in:	The European respiratory journal 2011-06, Vol.37 (6), p.1482-1493
Hauptverfasser:	ROBERTS, M. E, MAGOWAN, L, HALL, I. P, JOHNSON, S. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Asthma - enzymology Asthma - pathology Biological and medical sciences Bronchi - metabolism Bronchi - pathology Cell Adhesion Cell Line Cell Proliferation Cells, Cultured Collagen Type I - metabolism Discoidin Domain Receptor 1 Female Gene Knockdown Techniques Humans Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 7 - metabolism Matrix Metalloproteinase 9 - metabolism Medical sciences Middle Aged Pneumology Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Smoking - metabolism Wound Healing Young Adult
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