Residue-Specific Vibrational Echoes Yield 3D Structures of a Transmembrane Helix Dimer

Two-dimensional (2D) vibrational echo spectroscopy has previously been applied to structural determination of small peptides. Here we extend the technique to a more complex, biologically important system: the homodimeric transmembrane dimer from the α chain of the integrin α IIb β 3 . We prepared mi...

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