Cellular senescence induced by cathepsin X downregulation

Cellular senescence represents a powerful tumor suppressor mechanism to prevent proliferation and invasion of malignant cells. Since tumor cells as well as primary fibroblasts lacking the lysosomal cysteine-type carboxypeptidase cathepsin X exhibit a reduced invasive capacity, we hypothesized that t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of cell biology 2011-08, Vol.90 (8), p.678-686
Hauptverfasser:	Kraus, Steffen, Bunsen, Thea, Schuster, Simon, Cichoń, Monika A., Tacke, Marlene, Reinheckel, Thomas, Sommerhoff, Christian P., Jochum, Marianne, Nägler, Dorit K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics beta -Galactosidase beta-Galactosidase - analysis cathepsins Cathepsins - biosynthesis Cathepsins - genetics Caveolin Caveolins - biosynthesis Caveolins - genetics Cell body Cell Cycle Cell migration Cell Proliferation Cells, Cultured Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 - genetics Cysteine-type carboxypeptidase Down-Regulation Embryo fibroblasts Enzyme-Linked Immunosorbent Assay Fibroblast Fibroblasts - cytology Fibroblasts - metabolism Humans Invasion Mice Mice, Knockout Molecular modelling Neonates p53 protein Polymerase Chain Reaction Proliferation Protease RNA Interference RNA, Small Interfering Senescence siRNA Skin Tumor cells Tumor suppressor genes Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!