Comparison of pre-emptive ibuprofen, paracetamol, and placebo administration in reducing post-operative pain in primary tooth extraction
International Journal of Paediatric Dentistry 2011; 21: 306–313 Background. This study investigates preliminary investigations that a pre‐emptive analgesia administration may reduce post‐extraction pain. Aim. This prospective, placebo‐controlled, randomized, double‐blind trial was planned to compa...
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| container_title | International journal of paediatric dentistry |
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| creator | BAYGIN, OZGUL TUZUNER, TAMER ISIK, BERRIN KUSGOZ, ADEM TANRIVER, MEHMET |
| description | International Journal of Paediatric Dentistry 2011; 21: 306–313
Background. This study investigates preliminary investigations that a pre‐emptive analgesia administration may reduce post‐extraction pain.
Aim. This prospective, placebo‐controlled, randomized, double‐blind trial was planned to compare the efficacy of the pre‐emptive administration of ibuprofen, paracetamol, and placebo in reducing post‐extraction pain in children.
Design. Forty‐five children, ages 6–12, who needed primary mandibular molar tooth extraction were treated in paediatric dental clinics, with treatment preceded by local anaesthesia and analgesic drugs during the preoperative period. A five‐face scale was used to evaluate pain reaction during the injection, extraction, and post‐operative period. Self‐report scores were recorded when the local anaesthesia had been administered in soft tissues and both before and after the extraction was completed. The Kruskal–Wallis and Mann–Whitney U tests (with Bonferroni correction paired t‐test as the post hoc test) were used at a confidence level of 95%.
Results. The use of pre‐emptive analgesics showed lower scores compared to the placebo, irrespective of the age, weight, gender of the child, and the number of teeth extracted during the study period. Additionally, ibuprofen exhibited lower pain scores (P |
| doi_str_mv | 10.1111/j.1365-263X.2011.01124.x |
| format | Article |
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Background. This study investigates preliminary investigations that a pre‐emptive analgesia administration may reduce post‐extraction pain.
Aim. This prospective, placebo‐controlled, randomized, double‐blind trial was planned to compare the efficacy of the pre‐emptive administration of ibuprofen, paracetamol, and placebo in reducing post‐extraction pain in children.
Design. Forty‐five children, ages 6–12, who needed primary mandibular molar tooth extraction were treated in paediatric dental clinics, with treatment preceded by local anaesthesia and analgesic drugs during the preoperative period. A five‐face scale was used to evaluate pain reaction during the injection, extraction, and post‐operative period. Self‐report scores were recorded when the local anaesthesia had been administered in soft tissues and both before and after the extraction was completed. The Kruskal–Wallis and Mann–Whitney U tests (with Bonferroni correction paired t‐test as the post hoc test) were used at a confidence level of 95%.
Results. The use of pre‐emptive analgesics showed lower scores compared to the placebo, irrespective of the age, weight, gender of the child, and the number of teeth extracted during the study period. Additionally, ibuprofen exhibited lower pain scores (P < 0.05) compared to paracetamol at the 15‐min (P < 0.001) and 4‐h (P < 0.009) periods.
Conclusions. Preoperative use of ibuprofen and paracetamol may provide a pre‐emptive analgesic effect in paediatric patients who receive adequate analgesia during mandibular primary tooth extraction.</description><identifier>ISSN: 0960-7439</identifier><identifier>EISSN: 1365-263X</identifier><identifier>DOI: 10.1111/j.1365-263X.2011.01124.x</identifier><identifier>PMID: 21470320</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetaminophen - therapeutic use ; Analgesics ; Analgesics, Non-Narcotic - therapeutic use ; Anesthesia, Dental ; Anesthesia, Local ; Anesthetics, Local - administration & dosage ; Child ; Dentistry ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Ibuprofen - therapeutic use ; Injections ; Male ; Molar - surgery ; Pain Measurement ; Pain, Postoperative - prevention & control ; Placebos ; Postoperative Complications ; Postoperative period ; Premedication ; Prospective Studies ; Self Report ; Tooth Extraction ; Tooth, Deciduous - surgery ; Treatment Outcome</subject><ispartof>International journal of paediatric dentistry, 2011-07, Vol.21 (4), p.306-313</ispartof><rights>2011 The Authors. International Journal of Paediatric Dentistry © 2011 BSPD, IAPD and Blackwell Publishing Ltd</rights><rights>2011 The Authors. International Journal of Paediatric Dentistry © 2011 BSPD, IAPD and Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3854-31745868efb85acd641757f3309749a9fa9013bf89f880c9d4dddf5b1ee3c5243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-263X.2011.01124.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-263X.2011.01124.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21470320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BAYGIN, OZGUL</creatorcontrib><creatorcontrib>TUZUNER, TAMER</creatorcontrib><creatorcontrib>ISIK, BERRIN</creatorcontrib><creatorcontrib>KUSGOZ, ADEM</creatorcontrib><creatorcontrib>TANRIVER, MEHMET</creatorcontrib><title>Comparison of pre-emptive ibuprofen, paracetamol, and placebo administration in reducing post-operative pain in primary tooth extraction</title><title>International journal of paediatric dentistry</title><addtitle>Int J Paediatr Dent</addtitle><description>International Journal of Paediatric Dentistry 2011; 21: 306–313
Background. This study investigates preliminary investigations that a pre‐emptive analgesia administration may reduce post‐extraction pain.
Aim. This prospective, placebo‐controlled, randomized, double‐blind trial was planned to compare the efficacy of the pre‐emptive administration of ibuprofen, paracetamol, and placebo in reducing post‐extraction pain in children.
Design. Forty‐five children, ages 6–12, who needed primary mandibular molar tooth extraction were treated in paediatric dental clinics, with treatment preceded by local anaesthesia and analgesic drugs during the preoperative period. A five‐face scale was used to evaluate pain reaction during the injection, extraction, and post‐operative period. Self‐report scores were recorded when the local anaesthesia had been administered in soft tissues and both before and after the extraction was completed. The Kruskal–Wallis and Mann–Whitney U tests (with Bonferroni correction paired t‐test as the post hoc test) were used at a confidence level of 95%.
Results. The use of pre‐emptive analgesics showed lower scores compared to the placebo, irrespective of the age, weight, gender of the child, and the number of teeth extracted during the study period. Additionally, ibuprofen exhibited lower pain scores (P < 0.05) compared to paracetamol at the 15‐min (P < 0.001) and 4‐h (P < 0.009) periods.
Conclusions. Preoperative use of ibuprofen and paracetamol may provide a pre‐emptive analgesic effect in paediatric patients who receive adequate analgesia during mandibular primary tooth extraction.</description><subject>Acetaminophen - therapeutic use</subject><subject>Analgesics</subject><subject>Analgesics, Non-Narcotic - therapeutic use</subject><subject>Anesthesia, Dental</subject><subject>Anesthesia, Local</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Child</subject><subject>Dentistry</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Ibuprofen - therapeutic use</subject><subject>Injections</subject><subject>Male</subject><subject>Molar - surgery</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Placebos</subject><subject>Postoperative Complications</subject><subject>Postoperative period</subject><subject>Premedication</subject><subject>Prospective Studies</subject><subject>Self Report</subject><subject>Tooth Extraction</subject><subject>Tooth, Deciduous - surgery</subject><subject>Treatment Outcome</subject><issn>0960-7439</issn><issn>1365-263X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1u1DAUhS1ERYfCKyBLLNg0wb-xvWCBBhgqVS2LorKznPgGPCRxmh-YvgGPjdOZzqKWLNs637m61wchTElO03q_zSkvZMYK_iNnhNI8bSby3TO0OgrP0YqYgmRKcHOKXo7jlhAqCSMv0CmjQhHOyAr9W8e2d0MYY4djjfsBMmj7KfwBHMq5H2IN3TlOhKtgcm1szrHrPO6b9C4jdr4NXRinwU0hVQgdHsDPVeh-4j6OUxZ7WKRUrXfhQe-H0LrhHk8xTr8w7JK1Wryv0EntmhFeH84z9P3L55v11-zyenOx_niZVVxLkXGqhNSFhrrU0lW-EFRJVXNOjBLGmdoZQnlZa1NrTSrjhfe-liUF4JVkgp-hd_u6aba7GcbJtmGsoGlcB3EerVaEaSMLlci3T8htnIcuNWepFMIUVHKWqDcHai5b8PYwn3384gR82AN_QwP3R50Su0Rpt3ZJzC6J2SVK-xCl3dmLb5-WW_Jne3_6Ztgd_W74bVOTStrbq40lm9urG1YUlvH_aLWi1w</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>BAYGIN, OZGUL</creator><creator>TUZUNER, TAMER</creator><creator>ISIK, BERRIN</creator><creator>KUSGOZ, ADEM</creator><creator>TANRIVER, MEHMET</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201107</creationdate><title>Comparison of pre-emptive ibuprofen, paracetamol, and placebo administration in reducing post-operative pain in primary tooth extraction</title><author>BAYGIN, OZGUL ; TUZUNER, TAMER ; ISIK, BERRIN ; KUSGOZ, ADEM ; TANRIVER, MEHMET</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3854-31745868efb85acd641757f3309749a9fa9013bf89f880c9d4dddf5b1ee3c5243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetaminophen - therapeutic use</topic><topic>Analgesics</topic><topic>Analgesics, Non-Narcotic - therapeutic use</topic><topic>Anesthesia, Dental</topic><topic>Anesthesia, Local</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Child</topic><topic>Dentistry</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Ibuprofen - therapeutic use</topic><topic>Injections</topic><topic>Male</topic><topic>Molar - surgery</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Placebos</topic><topic>Postoperative Complications</topic><topic>Postoperative period</topic><topic>Premedication</topic><topic>Prospective Studies</topic><topic>Self Report</topic><topic>Tooth Extraction</topic><topic>Tooth, Deciduous - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BAYGIN, OZGUL</creatorcontrib><creatorcontrib>TUZUNER, TAMER</creatorcontrib><creatorcontrib>ISIK, BERRIN</creatorcontrib><creatorcontrib>KUSGOZ, ADEM</creatorcontrib><creatorcontrib>TANRIVER, MEHMET</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of paediatric dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BAYGIN, OZGUL</au><au>TUZUNER, TAMER</au><au>ISIK, BERRIN</au><au>KUSGOZ, ADEM</au><au>TANRIVER, MEHMET</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of pre-emptive ibuprofen, paracetamol, and placebo administration in reducing post-operative pain in primary tooth extraction</atitle><jtitle>International journal of paediatric dentistry</jtitle><addtitle>Int J Paediatr Dent</addtitle><date>2011-07</date><risdate>2011</risdate><volume>21</volume><issue>4</issue><spage>306</spage><epage>313</epage><pages>306-313</pages><issn>0960-7439</issn><eissn>1365-263X</eissn><abstract>International Journal of Paediatric Dentistry 2011; 21: 306–313
Background. This study investigates preliminary investigations that a pre‐emptive analgesia administration may reduce post‐extraction pain.
Aim. This prospective, placebo‐controlled, randomized, double‐blind trial was planned to compare the efficacy of the pre‐emptive administration of ibuprofen, paracetamol, and placebo in reducing post‐extraction pain in children.
Design. Forty‐five children, ages 6–12, who needed primary mandibular molar tooth extraction were treated in paediatric dental clinics, with treatment preceded by local anaesthesia and analgesic drugs during the preoperative period. A five‐face scale was used to evaluate pain reaction during the injection, extraction, and post‐operative period. Self‐report scores were recorded when the local anaesthesia had been administered in soft tissues and both before and after the extraction was completed. The Kruskal–Wallis and Mann–Whitney U tests (with Bonferroni correction paired t‐test as the post hoc test) were used at a confidence level of 95%.
Results. The use of pre‐emptive analgesics showed lower scores compared to the placebo, irrespective of the age, weight, gender of the child, and the number of teeth extracted during the study period. Additionally, ibuprofen exhibited lower pain scores (P < 0.05) compared to paracetamol at the 15‐min (P < 0.001) and 4‐h (P < 0.009) periods.
Conclusions. Preoperative use of ibuprofen and paracetamol may provide a pre‐emptive analgesic effect in paediatric patients who receive adequate analgesia during mandibular primary tooth extraction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21470320</pmid><doi>10.1111/j.1365-263X.2011.01124.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Acetaminophen - therapeutic use Analgesics Analgesics, Non-Narcotic - therapeutic use Anesthesia, Dental Anesthesia, Local Anesthetics, Local - administration & dosage Child Dentistry Double-Blind Method Female Follow-Up Studies Humans Ibuprofen - therapeutic use Injections Male Molar - surgery Pain Measurement Pain, Postoperative - prevention & control Placebos Postoperative Complications Postoperative period Premedication Prospective Studies Self Report Tooth Extraction Tooth, Deciduous - surgery Treatment Outcome |
| title | Comparison of pre-emptive ibuprofen, paracetamol, and placebo administration in reducing post-operative pain in primary tooth extraction |
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