Protein profiling for cancer biomarker discovery using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and infrared imaging: A review
Cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker might be either a molecule secreted by a tumor or it can be a specific response of the body to the presence of cancer. Cancer biomarker-based diagnostics have applications for esta...
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| Veröffentlicht in: | Analytica chimica acta 2011-03, Vol.690 (1), p.26-34 |
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| creator | Bakry, R. Rainer, M. Huck, C.W. Bonn, G.K. |
| description | Cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker might be either a molecule secreted by a tumor or it can be a specific response of the body to the presence of cancer. Cancer biomarker-based diagnostics have applications for establishing disease predisposition, early detection, cancer staging, therapy selection, identifying whether or not a cancer is metastatic, therapy monitoring, assessing prognosis, and advances in the adjuvant setting. Full adoption of cancer biomarkers in the clinic has to date been slow, and only a limited number of cancer biomarker products are currently in routine use.
Among proteomic technologies, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) is a technique that has allowed rapid progress in cancer biology. Different further developed methods including e.g. SELDI (surface-enhanced laser desorption/ionization) and MELDI (material-enhanced laser desorption/ionization) are simple and high-throughput techniques that analyze with high sensitivity and specificity intact proteins expressed in complex biological mixtures, such as serum, urine, and tissues. The combination of mass spectrometry (MS) with infrared (IR) spectroscopic imaging is an attempt to combine different technologies in systems analytics. Both MALDI-TOF and infrared tissue imaging enable studying proteins distribution in tissue samples with a resolution down to 50 and 5
μm, respectively.
In this review, we summarize recent applications and the synergistic combination of these new technologies to proteomic profiling for cancer biomarker discovery. |
| doi_str_mv | 10.1016/j.aca.2011.01.044 |
| format | Article |
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Among proteomic technologies, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) is a technique that has allowed rapid progress in cancer biology. Different further developed methods including e.g. SELDI (surface-enhanced laser desorption/ionization) and MELDI (material-enhanced laser desorption/ionization) are simple and high-throughput techniques that analyze with high sensitivity and specificity intact proteins expressed in complex biological mixtures, such as serum, urine, and tissues. The combination of mass spectrometry (MS) with infrared (IR) spectroscopic imaging is an attempt to combine different technologies in systems analytics. Both MALDI-TOF and infrared tissue imaging enable studying proteins distribution in tissue samples with a resolution down to 50 and 5
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Among proteomic technologies, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) is a technique that has allowed rapid progress in cancer biology. Different further developed methods including e.g. SELDI (surface-enhanced laser desorption/ionization) and MELDI (material-enhanced laser desorption/ionization) are simple and high-throughput techniques that analyze with high sensitivity and specificity intact proteins expressed in complex biological mixtures, such as serum, urine, and tissues. The combination of mass spectrometry (MS) with infrared (IR) spectroscopic imaging is an attempt to combine different technologies in systems analytics. Both MALDI-TOF and infrared tissue imaging enable studying proteins distribution in tissue samples with a resolution down to 50 and 5
μm, respectively.
In this review, we summarize recent applications and the synergistic combination of these new technologies to proteomic profiling for cancer biomarker discovery.</description><subject>Analytical chemistry</subject><subject>Biological and medical sciences</subject><subject>Biomarker</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - urine</subject><subject>Cancer</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Chemistry</subject><subject>Desorption</subject><subject>Diverse techniques</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Infrared spectroscopy</subject><subject>Ionization</subject><subject>Lasers</subject><subject>Mass spectrometry</subject><subject>Mathematical analysis</subject><subject>Molecular and cellular biology</subject><subject>Nanoparticles - chemistry</subject><subject>Neoplasms - diagnosis</subject><subject>Protein Array Analysis - methods</subject><subject>Protein Processing, Post-Translational</subject><subject>Protein profiling</subject><subject>Proteins</subject><subject>Spectrometric and optical methods</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</subject><subject>Spectrophotometry, Infrared - methods</subject><subject>Therapy</subject><issn>0003-2670</issn><issn>1873-4324</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EomXhAbggXxCnbO3Ymzhwqir-SZXgAGdrYk8WL0m82N6W8jg8KRPtAjeQxvJY-s2M5_sYeyrFWgrZXOzW4GBdCynXgkLre-xcmlZVWtX6PjsXQqiqblpxxh7lvKNnLYV-yM5qqaXWSp2znx9TLBhmvk9xCGOYt3yIiTuYHSbehzhB-kqZD9nFG0x3_JAXaIKSwvcKcg65oOcj5IXCHNO-hDhf0Ak_YEl5CRNWcaiGMWy_FCrNmec9upLihIVawux5mIcEiTqFCbY04SW_5AlvAt4-Zg8GGDM-Od0r9vnN609X76rrD2_fX11eV04bUSoA7XvptQTvdQtayg5Fa3qP3kjnW9WqupGowHfgQQ04dAp0L1ynGlP3nVqxF8e-JMW3A-ZiJ1oaxxFmjIdsTdMZvdGd-T-5aY3UzaYlUh5Jl2LOCQe7T7RgurNS2MVDu7PkoV08tIKCXFmxZ6fuh35C_6fit2kEPD8BkB2MpNvsQv7Lqa7phFmGvzpySKqRkslmF5CM9SGR-tbH8I9v_AJJVr4c</recordid><startdate>20110325</startdate><enddate>20110325</enddate><creator>Bakry, R.</creator><creator>Rainer, M.</creator><creator>Huck, C.W.</creator><creator>Bonn, G.K.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U5</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20110325</creationdate><title>Protein profiling for cancer biomarker discovery using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and infrared imaging: A review</title><author>Bakry, R. ; Rainer, M. ; Huck, C.W. ; Bonn, G.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-aa4db1d41add47a4119e078bded81cd7373261e3ad9ada3fef93a4b0c93682b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analytical chemistry</topic><topic>Biological and medical sciences</topic><topic>Biomarker</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - urine</topic><topic>Cancer</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Chemistry</topic><topic>Desorption</topic><topic>Diverse techniques</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Infrared spectroscopy</topic><topic>Ionization</topic><topic>Lasers</topic><topic>Mass spectrometry</topic><topic>Mathematical analysis</topic><topic>Molecular and cellular biology</topic><topic>Nanoparticles - chemistry</topic><topic>Neoplasms - diagnosis</topic><topic>Protein Array Analysis - methods</topic><topic>Protein Processing, Post-Translational</topic><topic>Protein profiling</topic><topic>Proteins</topic><topic>Spectrometric and optical methods</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</topic><topic>Spectrophotometry, Infrared - methods</topic><topic>Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakry, R.</creatorcontrib><creatorcontrib>Rainer, M.</creatorcontrib><creatorcontrib>Huck, C.W.</creatorcontrib><creatorcontrib>Bonn, G.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Analytica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakry, R.</au><au>Rainer, M.</au><au>Huck, C.W.</au><au>Bonn, G.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein profiling for cancer biomarker discovery using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and infrared imaging: A review</atitle><jtitle>Analytica chimica acta</jtitle><addtitle>Anal Chim Acta</addtitle><date>2011-03-25</date><risdate>2011</risdate><volume>690</volume><issue>1</issue><spage>26</spage><epage>34</epage><pages>26-34</pages><issn>0003-2670</issn><eissn>1873-4324</eissn><coden>ACACAM</coden><abstract>Cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker might be either a molecule secreted by a tumor or it can be a specific response of the body to the presence of cancer. Cancer biomarker-based diagnostics have applications for establishing disease predisposition, early detection, cancer staging, therapy selection, identifying whether or not a cancer is metastatic, therapy monitoring, assessing prognosis, and advances in the adjuvant setting. Full adoption of cancer biomarkers in the clinic has to date been slow, and only a limited number of cancer biomarker products are currently in routine use.
Among proteomic technologies, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) is a technique that has allowed rapid progress in cancer biology. Different further developed methods including e.g. SELDI (surface-enhanced laser desorption/ionization) and MELDI (material-enhanced laser desorption/ionization) are simple and high-throughput techniques that analyze with high sensitivity and specificity intact proteins expressed in complex biological mixtures, such as serum, urine, and tissues. The combination of mass spectrometry (MS) with infrared (IR) spectroscopic imaging is an attempt to combine different technologies in systems analytics. Both MALDI-TOF and infrared tissue imaging enable studying proteins distribution in tissue samples with a resolution down to 50 and 5
μm, respectively.
In this review, we summarize recent applications and the synergistic combination of these new technologies to proteomic profiling for cancer biomarker discovery.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21414433</pmid><doi>10.1016/j.aca.2011.01.044</doi><tpages>9</tpages></addata></record> |
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| issn | 0003-2670 1873-4324 |
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| subjects | Analytical chemistry Biological and medical sciences Biomarker Biomarkers, Tumor - analysis Biomarkers, Tumor - blood Biomarkers, Tumor - urine Cancer Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chemistry Desorption Diverse techniques Exact sciences and technology Fundamental and applied biological sciences. Psychology Humans Imaging Infrared spectroscopy Ionization Lasers Mass spectrometry Mathematical analysis Molecular and cellular biology Nanoparticles - chemistry Neoplasms - diagnosis Protein Array Analysis - methods Protein Processing, Post-Translational Protein profiling Proteins Spectrometric and optical methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectrophotometry, Infrared - methods Therapy |
| title | Protein profiling for cancer biomarker discovery using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and infrared imaging: A review |
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