The ventilation distribution of helium–oxygen mixtures and the role of inertial losses in the presence of heterogeneous airway obstructions
Abstract The regional distribution of inhaled gas within the lung is affected in part by normal variations in airway geometry or by obstructions resulting from disease. In the present work, the effects of heterogeneous airway obstructions on the distribution of air and helium–oxygen were examined us...
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| Veröffentlicht in: | Journal of biomechanics 2011-04, Vol.44 (6), p.1137-1143 |
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| container_title | Journal of biomechanics |
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| creator | Katz, Ira M Martin, Andrew R Muller, Pierre-Antoine Terzibachi, Karine Feng, Chia-Hsiang Caillibotte, Georges Sandeau, Julien Texereau, Joëlle |
| description | Abstract The regional distribution of inhaled gas within the lung is affected in part by normal variations in airway geometry or by obstructions resulting from disease. In the present work, the effects of heterogeneous airway obstructions on the distribution of air and helium–oxygen were examined using an in vitro model, the two compartments of a dual adult test lung. Breathing helium–oxygen resulted in a consistently more uniform distribution, with the gas volume delivered to a severely obstructed compartment increased by almost 80%. An engineering approach to pipe flow was used to analyze the test lung and was extrapolated to a human lung model to show that the in vitro experimental parameters are relevant to the observed in vivo conditions. The engineering analysis also showed that helium–oxygen can decrease the relative weight of the flow resistance due to obstructions if they are inertial in nature (i.e., density dependent) due to either turbulence or laminar convective losses. |
| doi_str_mv | 10.1016/j.jbiomech.2011.01.022 |
| format | Article |
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In the present work, the effects of heterogeneous airway obstructions on the distribution of air and helium–oxygen were examined using an in vitro model, the two compartments of a dual adult test lung. Breathing helium–oxygen resulted in a consistently more uniform distribution, with the gas volume delivered to a severely obstructed compartment increased by almost 80%. An engineering approach to pipe flow was used to analyze the test lung and was extrapolated to a human lung model to show that the in vitro experimental parameters are relevant to the observed in vivo conditions. The engineering analysis also showed that helium–oxygen can decrease the relative weight of the flow resistance due to obstructions if they are inertial in nature (i.e., density dependent) due to either turbulence or laminar convective losses.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2011.01.022</identifier><identifier>PMID: 21316683</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Airway Obstruction - physiopathology ; Airways ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Compartments ; Density ; Flow resistance ; Gynecology. Andrology. Obstetrics ; Helium ; Helium-Oxygen ; Heterogeneous obstruction ; Humans ; In vitro testing ; Inertial ; Lung - physiopathology ; Lungs ; Male genital diseases ; Mathematical model ; Medical sciences ; Models, Biological ; Obstructions ; Oxygen ; Physical Medicine and Rehabilitation ; Pneumology ; Pulmonary Ventilation ; Respiratory mechanics ; Tumors ; Turbulence ; Two-compartment test lung</subject><ispartof>Journal of biomechanics, 2011-04, Vol.44 (6), p.1137-1143</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-fd4fc26ef37290fe5efb2dcab7a24f9679d0875f052a438b7da9ca97733cfa033</citedby><cites>FETCH-LOGICAL-c578t-fd4fc26ef37290fe5efb2dcab7a24f9679d0875f052a438b7da9ca97733cfa033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021929011000534$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24066623$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21316683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katz, Ira M</creatorcontrib><creatorcontrib>Martin, Andrew R</creatorcontrib><creatorcontrib>Muller, Pierre-Antoine</creatorcontrib><creatorcontrib>Terzibachi, Karine</creatorcontrib><creatorcontrib>Feng, Chia-Hsiang</creatorcontrib><creatorcontrib>Caillibotte, Georges</creatorcontrib><creatorcontrib>Sandeau, Julien</creatorcontrib><creatorcontrib>Texereau, Joëlle</creatorcontrib><title>The ventilation distribution of helium–oxygen mixtures and the role of inertial losses in the presence of heterogeneous airway obstructions</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>Abstract The regional distribution of inhaled gas within the lung is affected in part by normal variations in airway geometry or by obstructions resulting from disease. In the present work, the effects of heterogeneous airway obstructions on the distribution of air and helium–oxygen were examined using an in vitro model, the two compartments of a dual adult test lung. Breathing helium–oxygen resulted in a consistently more uniform distribution, with the gas volume delivered to a severely obstructed compartment increased by almost 80%. An engineering approach to pipe flow was used to analyze the test lung and was extrapolated to a human lung model to show that the in vitro experimental parameters are relevant to the observed in vivo conditions. The engineering analysis also showed that helium–oxygen can decrease the relative weight of the flow resistance due to obstructions if they are inertial in nature (i.e., density dependent) due to either turbulence or laminar convective losses.</description><subject>Adult</subject><subject>Airway Obstruction - physiopathology</subject><subject>Airways</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Compartments</subject><subject>Density</subject><subject>Flow resistance</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Helium</subject><subject>Helium-Oxygen</subject><subject>Heterogeneous obstruction</subject><subject>Humans</subject><subject>In vitro testing</subject><subject>Inertial</subject><subject>Lung - physiopathology</subject><subject>Lungs</subject><subject>Male genital diseases</subject><subject>Mathematical model</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Obstructions</subject><subject>Oxygen</subject><subject>Physical Medicine and Rehabilitation</subject><subject>Pneumology</subject><subject>Pulmonary Ventilation</subject><subject>Respiratory mechanics</subject><subject>Tumors</subject><subject>Turbulence</subject><subject>Two-compartment test lung</subject><issn>0021-9290</issn><issn>1873-2380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks1u1DAUhS0EosPAK1SREGKVwT9JnGwQqOJPqsSCsrYc55rxkMSD7ZTOjhdg1Tfsk3AzM6VSN5UsRZG_e67vOZeQU0ZXjLLqzWa1aZ0fwKxXnDK2ong4f0QWrJYi56Kmj8mCUs7yhjf0hDyLcUMplYVsnpITzgSrqlosyN-LNWSXMCbX6-T8mHUupuDaaf_jbbaG3k3DzZ9rf7X7AWM2uKs0BYiZHrssYXHwPcygGyEkp_us9zHivRv311tkYTRw0EoQPKqAn1DAhd96l_kWG05m7hefkydW9xFeHL9L8v3jh4uzz_n5109fzt6f56aUdcptV1jDK7BC4nAWSrAt74xupeaFbSrZdLSWpaUl14WoW9npxuhGSiGM1VSIJXl90N0G_2uCmNTgooG-1_unqbpq6oIKWTxMlg0tRYGmL8nLe-TGT2HEMRSjomRoeFEiVR0oE9CmAFZtgxt02CGk5mTVRt0mq-ZkFcXDORaeHuWndoDuf9ltlAi8OgI6Gt3boEfj4h1X0Kqq-My9O3CABl86CCoaNyfUuQAmqc67h9_y9p6E6d3osOtP2EG8m1tFrqj6Nu_hvIaM4QqiW-If3tTdyw</recordid><startdate>20110407</startdate><enddate>20110407</enddate><creator>Katz, Ira M</creator><creator>Martin, Andrew R</creator><creator>Muller, Pierre-Antoine</creator><creator>Terzibachi, Karine</creator><creator>Feng, Chia-Hsiang</creator><creator>Caillibotte, Georges</creator><creator>Sandeau, Julien</creator><creator>Texereau, Joëlle</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TB</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110407</creationdate><title>The ventilation distribution of helium–oxygen mixtures and the role of inertial losses in the presence of heterogeneous airway obstructions</title><author>Katz, Ira M ; Martin, Andrew R ; Muller, Pierre-Antoine ; Terzibachi, Karine ; Feng, Chia-Hsiang ; Caillibotte, Georges ; Sandeau, Julien ; Texereau, Joëlle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-fd4fc26ef37290fe5efb2dcab7a24f9679d0875f052a438b7da9ca97733cfa033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Airway Obstruction - physiopathology</topic><topic>Airways</topic><topic>Biological and medical sciences</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Compartments</topic><topic>Density</topic><topic>Flow resistance</topic><topic>Gynecology. 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In the present work, the effects of heterogeneous airway obstructions on the distribution of air and helium–oxygen were examined using an in vitro model, the two compartments of a dual adult test lung. Breathing helium–oxygen resulted in a consistently more uniform distribution, with the gas volume delivered to a severely obstructed compartment increased by almost 80%. An engineering approach to pipe flow was used to analyze the test lung and was extrapolated to a human lung model to show that the in vitro experimental parameters are relevant to the observed in vivo conditions. The engineering analysis also showed that helium–oxygen can decrease the relative weight of the flow resistance due to obstructions if they are inertial in nature (i.e., density dependent) due to either turbulence or laminar convective losses.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21316683</pmid><doi>10.1016/j.jbiomech.2011.01.022</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Airway Obstruction - physiopathology Airways Biological and medical sciences Chronic obstructive pulmonary disease, asthma Compartments Density Flow resistance Gynecology. Andrology. Obstetrics Helium Helium-Oxygen Heterogeneous obstruction Humans In vitro testing Inertial Lung - physiopathology Lungs Male genital diseases Mathematical model Medical sciences Models, Biological Obstructions Oxygen Physical Medicine and Rehabilitation Pneumology Pulmonary Ventilation Respiratory mechanics Tumors Turbulence Two-compartment test lung |
| title | The ventilation distribution of helium–oxygen mixtures and the role of inertial losses in the presence of heterogeneous airway obstructions |
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