Influence of reaction conditions on the enantioselectivity of biocatalyzed C–C bond formations under high pressure conditions

Benzoylformate decarboxylase (BFD, EC 4.1.1.7) is a homotetrameric thiamine diphosphate (ThDP)-dependent enzyme which catalyzes the synthesis of chiral 2-hydroxyketones accepting a broad range of aldehydes as substrates. In this study the synthesis of 2-hydroxypropiophenone (2-HPP) from benzaldehyde...

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Veröffentlicht in:	Journal of biotechnology 2011-03, Vol.152 (3), p.87-92
Hauptverfasser:	Kara, Selin, Long, Wei Sing, Berheide, Marco, Peper, Stephanie, Niemeyer, Bernd, Liese, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	acetaldehyde benzaldehyde Benzaldehydes - chemistry Benzaldehydes - metabolism Benzaldehydes - pharmacology Benzoylformate decarboxylase Biocatalysis - drug effects Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology biotransformation Carboxy-Lyases - metabolism C–C bond formation enantiomers Enantioselectivity Enzymatic catalysis Fundamental and applied biological sciences. Psychology High pressure catalysis Hydrogen-Ion Concentration - drug effects Hydroxypropiophenone - chemistry Hydroxypropiophenone - metabolism Methods. Procedures. Technologies Pressure Stereoisomerism Substrate Specificity - drug effects thiamin
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