The potential of nanoscale combinations of self-assembling peptides and amino acids of the Src tyrosine kinase inhibitor in acute lung injury therapy

Abstract Many newly discovered therapeutic agents require a delivery platform in order to translate them into clinical applications. For this purpose, a nanoscale formulation strategy was developed for the Src tyrosine kinase inhibitor PP2. The formulation utilizes the combination of the self-assemb...

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Veröffentlicht in:	Biomaterials 2011-06, Vol.32 (16), p.4000-4008
Hauptverfasser:	Fung, Shan-Yu, Oyaizu, Takeshi, Yang, Hong, Yuan, Yongfang, Han, Bing, Keshavjee, Shaf, Liu, Mingyao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute inflammatory response Acute Lung Injury - chemically induced Acute Lung Injury - drug therapy Advanced Basic Science Amino Acids - chemistry Amino Acids - therapeutic use Animals Biocompatibility Blotting, Western Cell Line Dentistry Drug delivery Hemolysis - drug effects Humans Lipopolysaccharides - toxicity Male Mice Mice, Inbred BALB C Nanoformulation NIH 3T3 Cells Oligopeptides - therapeutic use Pyrimidines - chemistry Pyrimidines - therapeutic use Rats Rats, Sprague-Dawley Self-assembling peptide
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