Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics
It is well-known that cell cycle arrest and/or death play a pivotal role in tumor progression, which has drawn a rising attention for cancer biologists due to their complex and intricate relationships. In this review, we demonstrate the recent research on oridonin, an active diterpenoid with remarka...
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| Veröffentlicht in: | The international journal of biochemistry & cell biology 2011-05, Vol.43 (5), p.701-704 |
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| container_issue | 5 |
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| container_title | The international journal of biochemistry & cell biology |
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| creator | Li, Chun-yang Wang, En-qin Cheng, Yan Bao, Jin-ku |
| description | It is well-known that cell cycle arrest and/or death play a pivotal role in tumor progression, which has drawn a rising attention for cancer biologists due to their complex and intricate relationships. In this review, we demonstrate the recent research on oridonin, an active diterpenoid with remarkable anti-proliferative activities, and then further explore its molecular mechanisms of cell cycle arrest, apoptosis, autophagy and their cross-talks in various cancer cells, which may provide a new perspective of oridonin as a candidate anti-neoplastic drug for future cancer therapeutics. |
| doi_str_mv | 10.1016/j.biocel.2011.01.020 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1357-2725 |
| ispartof | The international journal of biochemistry & cell biology, 2011-05, Vol.43 (5), p.701-704 |
| issn | 1357-2725 1878-5875 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-neoplastic drug antineoplastic agents Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Biochemistry Biologists Biology Cancer Cell Cycle - drug effects Cell cycle arrest cell cycle checkpoints Cell Line, Tumor Death Diterpenes, Kaurane - chemistry Diterpenes, Kaurane - pharmacology Diterpenes, Kaurane - therapeutic use diterpenoids Drug Stability Drugs Humans neoplasm cells Neoplasms - drug therapy Neoplasms - pathology Oridonin Pathways Progressions therapeutics Tumors |
| title | Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics |
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