The synthesis, mass spectrometric properties and identification of some N , N -di-(β-arylisopropyl)formamides related to the synthesis of ring-modified amphetamines
Abstract This study examines the electron impact (EI) induced mass spectrometric behavior of several N , N -di-(β-arylisopropyl)formamides, which are connected to the Leuckart synthesis of some amphetamine analogues. Emphasis is laid on the fragmentation paths, which are common for all compounds und...
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| Veröffentlicht in: | Forensic science international 2011-03, Vol.206 (1), p.197-206 |
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| container_title | Forensic science international |
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| creator | Błachut, Dariusz Danikiewicz, Witold Wojtasiewicz, Krystyna Olejnik, Marian Kalinowska, Iwona Szawkało, Joanna Czarnocki, Zbigniew |
| description | Abstract This study examines the electron impact (EI) induced mass spectrometric behavior of several N , N -di-(β-arylisopropyl)formamides, which are connected to the Leuckart synthesis of some amphetamine analogues. Emphasis is laid on the fragmentation paths, which are common for all compounds under investigation and may be used in construction of the prediction scheme useful for identification of similar impurities, especially in absence of desirable authentic material. On the basis of this scheme several new N , N -di-(β-arylisopropyl)formamides have been identified in selected amphetamine analogues synthesized by the Leuckart method, including 4-methylthioamphetamine (4-MTA), 4-fluoroamphetamine (4-FA), 4-methylamphetamine, 3-trifluoromethylamphetamine, 3,4-methylenedioxyamphetamine (MDA), 2,5-dimethoxyamphetamine (2,5-DMA), 2,4,5- and 3,4,5-trimethoxyamphetamines (2-TMA and 3-TMA). |
| doi_str_mv | 10.1016/j.forsciint.2010.08.007 |
| format | Article |
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Emphasis is laid on the fragmentation paths, which are common for all compounds under investigation and may be used in construction of the prediction scheme useful for identification of similar impurities, especially in absence of desirable authentic material. On the basis of this scheme several new N , N -di-(β-arylisopropyl)formamides have been identified in selected amphetamine analogues synthesized by the Leuckart method, including 4-methylthioamphetamine (4-MTA), 4-fluoroamphetamine (4-FA), 4-methylamphetamine, 3-trifluoromethylamphetamine, 3,4-methylenedioxyamphetamine (MDA), 2,5-dimethoxyamphetamine (2,5-DMA), 2,4,5- and 3,4,5-trimethoxyamphetamines (2-TMA and 3-TMA).</description><identifier>ISSN: 0379-0738</identifier><identifier>EISSN: 1872-6283</identifier><identifier>DOI: 10.1016/j.forsciint.2010.08.007</identifier><identifier>PMID: 20846801</identifier><identifier>CODEN: FSINDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Aldehydes ; Amphetamine analogues ; Amphetamines ; Analytical chemistry ; Biological and medical sciences ; Chemical synthesis ; Construction materials ; Electron impact ; Electrons ; Forensic chemistry ; Forensic medicine ; Forensic science ; Forensic sciences ; Fragmentation ; General aspects ; Impurities ; Investigative techniques, diagnostic techniques (general aspects) ; Leuckart synthesis ; Mass spectrometry ; Materials selection ; Medical sciences ; Pathology ; Public health. 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Mar 20, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-af1a8e6e1623d402bcc57b4f3e7084bd5e513439b964521a98a10ee29252adee3</citedby><cites>FETCH-LOGICAL-c542t-af1a8e6e1623d402bcc57b4f3e7084bd5e513439b964521a98a10ee29252adee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1033339009?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23977191$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20846801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Błachut, Dariusz</creatorcontrib><creatorcontrib>Danikiewicz, Witold</creatorcontrib><creatorcontrib>Wojtasiewicz, Krystyna</creatorcontrib><creatorcontrib>Olejnik, Marian</creatorcontrib><creatorcontrib>Kalinowska, Iwona</creatorcontrib><creatorcontrib>Szawkało, Joanna</creatorcontrib><creatorcontrib>Czarnocki, Zbigniew</creatorcontrib><title>The synthesis, mass spectrometric properties and identification of some N , N -di-(β-arylisopropyl)formamides related to the synthesis of ring-modified amphetamines</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>Abstract This study examines the electron impact (EI) induced mass spectrometric behavior of several N , N -di-(β-arylisopropyl)formamides, which are connected to the Leuckart synthesis of some amphetamine analogues. Emphasis is laid on the fragmentation paths, which are common for all compounds under investigation and may be used in construction of the prediction scheme useful for identification of similar impurities, especially in absence of desirable authentic material. On the basis of this scheme several new N , N -di-(β-arylisopropyl)formamides have been identified in selected amphetamine analogues synthesized by the Leuckart method, including 4-methylthioamphetamine (4-MTA), 4-fluoroamphetamine (4-FA), 4-methylamphetamine, 3-trifluoromethylamphetamine, 3,4-methylenedioxyamphetamine (MDA), 2,5-dimethoxyamphetamine (2,5-DMA), 2,4,5- and 3,4,5-trimethoxyamphetamines (2-TMA and 3-TMA).</description><subject>Aldehydes</subject><subject>Amphetamine analogues</subject><subject>Amphetamines</subject><subject>Analytical chemistry</subject><subject>Biological and medical sciences</subject><subject>Chemical synthesis</subject><subject>Construction materials</subject><subject>Electron impact</subject><subject>Electrons</subject><subject>Forensic chemistry</subject><subject>Forensic medicine</subject><subject>Forensic science</subject><subject>Forensic sciences</subject><subject>Fragmentation</subject><subject>General aspects</subject><subject>Impurities</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leuckart synthesis</subject><subject>Mass spectrometry</subject><subject>Materials selection</subject><subject>Medical sciences</subject><subject>Pathology</subject><subject>Public health. 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| fulltext | fulltext |
| identifier | ISSN: 0379-0738 |
| ispartof | Forensic science international, 2011-03, Vol.206 (1), p.197-206 |
| issn | 0379-0738 1872-6283 |
| language | eng |
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| source | Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Aldehydes Amphetamine analogues Amphetamines Analytical chemistry Biological and medical sciences Chemical synthesis Construction materials Electron impact Electrons Forensic chemistry Forensic medicine Forensic science Forensic sciences Fragmentation General aspects Impurities Investigative techniques, diagnostic techniques (general aspects) Leuckart synthesis Mass spectrometry Materials selection Medical sciences Pathology Public health. Hygiene Public health. Hygiene-occupational medicine Spectroscopy Synthesis |
| title | The synthesis, mass spectrometric properties and identification of some N , N -di-(β-arylisopropyl)formamides related to the synthesis of ring-modified amphetamines |
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