Single chain anti-c-Met antibody conjugated nanoparticles for in vivo tumor-targeted imaging and drug delivery

Abstract Aberrantly expressed c-Met, the receptor for hepatocyte growth factor (HGF), has been implicated in human lung cancer as well as malignancy, metastasis and drug-resistance in other human cancers. Thus, this molecule could be a potential target for antibody-based cancer therapy. Targeting de...

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Veröffentlicht in:	Biomaterials 2011-04, Vol.32 (12), p.3265-3274
Hauptverfasser:	Lu, Ruei-Min, Chang, Yu-Ling, Chen, Min-Shan, Wu, Han-Chung
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Amino Acid Sequence Animals c-Met Cell Death - drug effects Cell Line, Tumor Dentistry Diagnostic Imaging Doxorubicin - pharmacology Doxorubicin - therapeutic use Drug delivery system Drug Delivery Systems - methods Endocytosis - drug effects Humans Immunoliposome Intracellular Space - drug effects Intracellular Space - metabolism Kinetics Lung Neoplasms - therapy Mice Microscopy, Confocal Molecular Sequence Data Nanoparticles - therapeutic use Neoplasms - drug therapy Neoplasms - pathology Organ Specificity - drug effects Peptide Library Phage display Protein Binding - drug effects Proto-Oncogene Proteins c-met - immunology scFv Single-Chain Antibodies - chemistry Single-Chain Antibodies - immunology Xenograft Model Antitumor Assays
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