Palytoxin toxicology: Animal studies

Palytoxin and its derivatives have been implicated in toxic events in humans following ingestion or inhalation, and many studies on the toxicities of these substances to animals, via various routes of administration, have been described. In this report, the toxicity of palytoxin to animals has been...

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Veröffentlicht in:	Toxicon (Oxford) 2011-03, Vol.57 (3), p.470-477
1. Verfasser:	Munday, Rex
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - toxicity Animals Apoptosis - drug effects Arrhythmias, Cardiac - chemically induced breathing Carcinogens - toxicity Dose-Response Relationship, Drug humans ingestion mechanism of action Mutagens - toxicity Necrosis - chemically induced Palytoxin Regulatory limits risk assessment Species Specificity toxicity Toxicity Tests, Acute Toxicity to animals toxicology
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Beschreibung
Zusammenfassung:	Palytoxin and its derivatives have been implicated in toxic events in humans following ingestion or inhalation, and many studies on the toxicities of these substances to animals, via various routes of administration, have been described. In this report, the toxicity of palytoxin to animals has been reviewed, with comments on possible mechanisms of action. Information required for the risk assessment of palytoxin and its derivatives is by no means complete, and recommendations for further studies, which may better inform regulatory decisions regarding these substances, are also discussed.
ISSN:	0041-0101 1879-3150
DOI:	10.1016/j.toxicon.2010.10.003