Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

DNA-encoded chemical libraries, i.e., collections of compounds individually coupled to distinctive DNA fragments serving as amplifiable identification barcodes, represent a new tool for the de novo discovery of small molecule ligands to target proteins of pharmaceutical interest. Here, we describe t...

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Veröffentlicht in:	ACS chemical biology 2011-04, Vol.6 (4), p.336-344
Hauptverfasser:	Buller, Fabian, Steiner, Martina, Frey, Katharina, Mircsof, Dennis, Scheuermann, Jörg, Kalisch, Markus, Bühlmann, Peter, Supuran, Claudiu T, Neri, Dario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Antigens, Neoplasm - metabolism Carbonic Anhydrase Inhibitors - chemical synthesis Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrase IX Carbonic Anhydrases - metabolism Cell Line, Tumor Colorectal Neoplasms - drug therapy Combinatorial Chemistry Techniques - methods DNA - chemistry Fluorescent Dyes - analysis Gene Library High-Throughput Nucleotide Sequencing High-Throughput Screening Assays Humans Kinetics Molecular Imaging Molecular Targeted Therapy Neoplasm Transplantation Quantitative Structure-Activity Relationship Small Molecule Libraries - chemical synthesis Small Molecule Libraries - pharmacology Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - pharmacology
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