A simple mass-action model for the eukaryotic heat shock response and its mathematical validation
The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cel...
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| Veröffentlicht in: | Natural computing 2011-03, Vol.10 (1), p.595-612 |
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| container_title | Natural computing |
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| creator | Petre, Ion Mizera, Andrzej Hyder, Claire L. Meinander, Annika Mikhailov, Andrey Morimoto, Richard I. Sistonen, Lea Eriksson, John E. Back, Ralph-Johan |
| description | The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides a useful foundation for modeling strategies of more complex cellular processes. |
| doi_str_mv | 10.1007/s11047-010-9216-y |
| format | Article |
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It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides a useful foundation for modeling strategies of more complex cellular processes.</description><identifier>ISSN: 1567-7818</identifier><identifier>EISSN: 1572-9796</identifier><identifier>DOI: 10.1007/s11047-010-9216-y</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Artificial Intelligence ; Cellular ; Cellular communication ; Complex Systems ; Computational mathematics ; Computer Science ; Control ; Eukaryotes ; Evolutionary Biology ; Foundations ; Heat shock ; Heat shock proteins ; Mathematical models ; Numerical prediction ; Processor Architectures ; Protein folding ; Sensitivity analysis ; Strategy ; Theory of Computation</subject><ispartof>Natural computing, 2011-03, Vol.10 (1), p.595-612</ispartof><rights>Springer Science+Business Media B.V. 2010</rights><rights>Springer Science+Business Media B.V. 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-1019e74aef53f7d27ccd025274e9eda83a1ab5e86f7ddff861fe71bd6e0b13203</citedby><cites>FETCH-LOGICAL-c347t-1019e74aef53f7d27ccd025274e9eda83a1ab5e86f7ddff861fe71bd6e0b13203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11047-010-9216-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11047-010-9216-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Petre, Ion</creatorcontrib><creatorcontrib>Mizera, Andrzej</creatorcontrib><creatorcontrib>Hyder, Claire L.</creatorcontrib><creatorcontrib>Meinander, Annika</creatorcontrib><creatorcontrib>Mikhailov, Andrey</creatorcontrib><creatorcontrib>Morimoto, Richard I.</creatorcontrib><creatorcontrib>Sistonen, Lea</creatorcontrib><creatorcontrib>Eriksson, John E.</creatorcontrib><creatorcontrib>Back, Ralph-Johan</creatorcontrib><title>A simple mass-action model for the eukaryotic heat shock response and its mathematical validation</title><title>Natural computing</title><addtitle>Nat Comput</addtitle><description>The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. 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| subjects | Artificial Intelligence Cellular Cellular communication Complex Systems Computational mathematics Computer Science Control Eukaryotes Evolutionary Biology Foundations Heat shock Heat shock proteins Mathematical models Numerical prediction Processor Architectures Protein folding Sensitivity analysis Strategy Theory of Computation |
| title | A simple mass-action model for the eukaryotic heat shock response and its mathematical validation |
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