Function of K+–Cl− Cotransporters in the Acid Secretory Mechanism of Gastric Parietal Cells

Gastric proton pump (H+, K+-ATPase) secretes H+ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl−- and K+-transporting proteins are required. Recent our studies have demonstrated that K+–Cl− cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. K...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2011/06/01, Vol.34(6), pp.810-812
Hauptverfasser:	Fujii, Takuto, Fujita, Kyosuke, Takeguchi, Noriaki, Sakai, Hideki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Polarity Gastric Acid - metabolism gastric acid secretion gastric parietal cell H+, K+-ATPase Humans K+–Cl− cotransporter Membrane Microdomains - metabolism Na+, K+-ATPase Parietal Cells, Gastric - metabolism Protein Isoforms - metabolism Proton Pumps - metabolism Secretory Pathway Sodium-Potassium-Exchanging ATPase - metabolism Symporters - metabolism
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