Function of K+–Cl− Cotransporters in the Acid Secretory Mechanism of Gastric Parietal Cells
Gastric proton pump (H+, K+-ATPase) secretes H+ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl−- and K+-transporting proteins are required. Recent our studies have demonstrated that K+–Cl− cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. K...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2011/06/01, Vol.34(6), pp.810-812 |
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| creator | Fujii, Takuto Fujita, Kyosuke Takeguchi, Noriaki Sakai, Hideki |
| description | Gastric proton pump (H+, K+-ATPase) secretes H+ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl−- and K+-transporting proteins are required. Recent our studies have demonstrated that K+–Cl− cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na+, K+-ATPase in the basolateral membrane, and KCC4 is associated with H+, K+-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells. |
| doi_str_mv | 10.1248/bpb.34.810 |
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For the HCl secretion, Cl−- and K+-transporting proteins are required. Recent our studies have demonstrated that K+–Cl− cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na+, K+-ATPase in the basolateral membrane, and KCC4 is associated with H+, K+-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.34.810</identifier><identifier>PMID: 21628876</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Cell Polarity ; Gastric Acid - metabolism ; gastric acid secretion ; gastric parietal cell ; H+, K+-ATPase ; Humans ; K+–Cl− cotransporter ; Membrane Microdomains - metabolism ; Na+, K+-ATPase ; Parietal Cells, Gastric - metabolism ; Protein Isoforms - metabolism ; Proton Pumps - metabolism ; Secretory Pathway ; Sodium-Potassium-Exchanging ATPase - metabolism ; Symporters - metabolism</subject><ispartof>Biological and Pharmaceutical Bulletin, 2011/06/01, Vol.34(6), pp.810-812</ispartof><rights>2011 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c663t-d84ee639fde7dba7ad940913307ce0adf51d9b1642a9916684056b7f639480903</citedby><cites>FETCH-LOGICAL-c663t-d84ee639fde7dba7ad940913307ce0adf51d9b1642a9916684056b7f639480903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27901,27902,27903</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21628876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujii, Takuto</creatorcontrib><creatorcontrib>Fujita, Kyosuke</creatorcontrib><creatorcontrib>Takeguchi, Noriaki</creatorcontrib><creatorcontrib>Sakai, Hideki</creatorcontrib><creatorcontrib>University of Toyama</creatorcontrib><creatorcontrib>Graduate School of Medicine and Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Department of Pharmaceutical Physiology</creatorcontrib><title>Function of K+–Cl− Cotransporters in the Acid Secretory Mechanism of Gastric Parietal Cells</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Gastric proton pump (H+, K+-ATPase) secretes H+ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl−- and K+-transporting proteins are required. Recent our studies have demonstrated that K+–Cl− cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na+, K+-ATPase in the basolateral membrane, and KCC4 is associated with H+, K+-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.</description><subject>Animals</subject><subject>Cell Polarity</subject><subject>Gastric Acid - metabolism</subject><subject>gastric acid secretion</subject><subject>gastric parietal cell</subject><subject>H+, K+-ATPase</subject><subject>Humans</subject><subject>K+–Cl− cotransporter</subject><subject>Membrane Microdomains - metabolism</subject><subject>Na+, K+-ATPase</subject><subject>Parietal Cells, Gastric - metabolism</subject><subject>Protein Isoforms - metabolism</subject><subject>Proton Pumps - metabolism</subject><subject>Secretory Pathway</subject><subject>Sodium-Potassium-Exchanging ATPase - metabolism</subject><subject>Symporters - metabolism</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUT2P1DAQtRCIWxYafgCyRIEE2sWOHX9U6BRxC-IQSEBtOc6E8yobL7ZTXEdJDf_wfgmOcntIFJ4p5r03b54RekrJllZcvW6P7ZbxraLkHlpRxuWmrmh9H62IpmojaK3O0KOU9oQQSSr2EJ1VVFRKSbFC5mIaXfZhxKHHH17d_PzTDDe_fuMm5GjHdAwxQ0zYjzhfAT53vsNfwEXIIV7jj-Cu7OjTYSbvbMrRO_zZRg_ZDriBYUiP0YPeDgme3PY1-nbx9mvzbnP5afe-Ob_cOCFY3nSKAwim-w5k11ppO82Le8aIdEBs19e00y0VvLJaUyEUJ7VoZV8oXBFN2Bq9WHSPMfyYIGVz8MkVB3aEMCWjhJZa0nL-Gj3_D7kPUxyLOUM510yRSs56LxeUiyGlCL05Rn-w8dpQYubUTUndMG5K6gX87FZyag_Q3UFPMRfAbgGUqXd2COPgR_i32CXZ-jAEUxFKDSGME1FaeUV-LhXlQtakLkpvFqV9yvY73K2yMXs3wMmVWMrMPk3KV0UDI_sLTi-qZQ</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Fujii, Takuto</creator><creator>Fujita, Kyosuke</creator><creator>Takeguchi, Noriaki</creator><creator>Sakai, Hideki</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Function of K+–Cl− Cotransporters in the Acid Secretory Mechanism of Gastric Parietal Cells</title><author>Fujii, Takuto ; Fujita, Kyosuke ; Takeguchi, Noriaki ; Sakai, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c663t-d84ee639fde7dba7ad940913307ce0adf51d9b1642a9916684056b7f639480903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Cell Polarity</topic><topic>Gastric Acid - metabolism</topic><topic>gastric acid secretion</topic><topic>gastric parietal cell</topic><topic>H+, K+-ATPase</topic><topic>Humans</topic><topic>K+–Cl− cotransporter</topic><topic>Membrane Microdomains - metabolism</topic><topic>Na+, K+-ATPase</topic><topic>Parietal Cells, Gastric - metabolism</topic><topic>Protein Isoforms - metabolism</topic><topic>Proton Pumps - metabolism</topic><topic>Secretory Pathway</topic><topic>Sodium-Potassium-Exchanging ATPase - metabolism</topic><topic>Symporters - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujii, Takuto</creatorcontrib><creatorcontrib>Fujita, Kyosuke</creatorcontrib><creatorcontrib>Takeguchi, Noriaki</creatorcontrib><creatorcontrib>Sakai, Hideki</creatorcontrib><creatorcontrib>University of Toyama</creatorcontrib><creatorcontrib>Graduate School of Medicine and Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Department of Pharmaceutical Physiology</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujii, Takuto</au><au>Fujita, Kyosuke</au><au>Takeguchi, Noriaki</au><au>Sakai, Hideki</au><aucorp>University of Toyama</aucorp><aucorp>Graduate School of Medicine and Pharmaceutical Sciences</aucorp><aucorp>Department of Pharmaceutical Physiology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Function of K+–Cl− Cotransporters in the Acid Secretory Mechanism of Gastric Parietal Cells</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2011</date><risdate>2011</risdate><volume>34</volume><issue>6</issue><spage>810</spage><epage>812</epage><pages>810-812</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Gastric proton pump (H+, K+-ATPase) secretes H+ of acid (HCl) via the luminal membrane of parietal cells. 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| subjects | Animals Cell Polarity Gastric Acid - metabolism gastric acid secretion gastric parietal cell H+, K+-ATPase Humans K+–Cl− cotransporter Membrane Microdomains - metabolism Na+, K+-ATPase Parietal Cells, Gastric - metabolism Protein Isoforms - metabolism Proton Pumps - metabolism Secretory Pathway Sodium-Potassium-Exchanging ATPase - metabolism Symporters - metabolism |
| title | Function of K+–Cl− Cotransporters in the Acid Secretory Mechanism of Gastric Parietal Cells |
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