Functional state of rat cardiomyocytes and blood antioxidant system under psycho-emotional stress
We studied the functionality of the antioxidant system in laboratory rat cardiomyocytes and blood under psychoemotional stress. It was found that 40-day isolation and violation of diurnal cycle among the animals were accompanied by the intensification of lipid peroxidation process and marked with a...
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| Veröffentlicht in: | Acta biochimica et biophysica Sinica 2011-06, Vol.43 (6), p.480-486 |
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| container_title | Acta biochimica et biophysica Sinica |
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| creator | Kuchukashvili, Zurab Menabde, Ketevan Chachua, Matrona Burjanadze, George Chipashvili, Manana Koshoridze, Nana |
| description | We studied the functionality of the antioxidant system in laboratory rat cardiomyocytes and blood under psychoemotional stress. It was found that 40-day isolation and violation of diurnal cycle among the animals were accompanied by the intensification of lipid peroxidation process and marked with a reduced activity of antioxidant system enzymes, such as catalase and superoxide dismutase activity. The results suggested that psycho-emotional stress was accompanied by oxidative stress, causing a reduction in the intensity of energy metabolism in cardio- myocytes, which was further strengthened by the fact that the activity of the enzymes involved in ATP synthesis in mitochondria was reduced. Based on the results, we proposed that psychological stress is one of the factors contributing to the development of various cardiac diseases. |
| doi_str_mv | 10.1093/abbs/gmr037 |
| format | Article |
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It was found that 40-day isolation and violation of diurnal cycle among the animals were accompanied by the intensification of lipid peroxidation process and marked with a reduced activity of antioxidant system enzymes, such as catalase and superoxide dismutase activity. The results suggested that psycho-emotional stress was accompanied by oxidative stress, causing a reduction in the intensity of energy metabolism in cardio- myocytes, which was further strengthened by the fact that the activity of the enzymes involved in ATP synthesis in mitochondria was reduced. 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It was found that 40-day isolation and violation of diurnal cycle among the animals were accompanied by the intensification of lipid peroxidation process and marked with a reduced activity of antioxidant system enzymes, such as catalase and superoxide dismutase activity. The results suggested that psycho-emotional stress was accompanied by oxidative stress, causing a reduction in the intensity of energy metabolism in cardio- myocytes, which was further strengthened by the fact that the activity of the enzymes involved in ATP synthesis in mitochondria was reduced. 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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antioxidants - metabolism Circadian Rhythm Energy Metabolism - physiology Lipid Peroxidation Lipids - blood Male Myocytes, Cardiac - metabolism Nitric Oxide - blood Rats Rats, Wistar Social Isolation Stress, Psychological - blood Stress, Psychological - physiopathology 心理压力 心理情绪 心肌细胞 抗氧化系统 氧化应激反应 状态 血液 超氧化物歧化酶活性 |
| title | Functional state of rat cardiomyocytes and blood antioxidant system under psycho-emotional stress |
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