Histomorphometric alteration of knee articular cartilage and serum alkaline phosphatase in young female mice by chronic supplementation with soybean
The purpose of the present study was to examine the effect of soybean supplementation on cartilage thickness in the knee joint and serum levels of alkaline phosphatase (ALP) in mice. Forty female mice were fed for 6 months on one of four regimens: low protein, complete protein without soybean, and c...
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| Veröffentlicht in: | Phytotherapy research 2011-06, Vol.25 (6), p.886-891 |
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| creator | Fazelipour, S. Tootian, Z. Matini, E. Hadipour-Jahromy, M. |
| description | The purpose of the present study was to examine the effect of soybean supplementation on cartilage thickness in the knee joint and serum levels of alkaline phosphatase (ALP) in mice. Forty female mice were fed for 6 months on one of four regimens: low protein, complete protein without soybean, and complete protein containing either 20% or 40% soybean. Body weight differences, histological and histomorphometric analysis, and ALP levels were determined and compared after 6 months. The results showed a significant increase in serum ALP activity and cartilage thickness in both groups fed on soybean‐containing diets, compared with the other groups. Additionally, the number of chondrocytes was significantly increased (p < 0.001) in the group taking the 40% soybean regimen, and the proteoglycan content of the intracellular fluid in the tibia was higher in those groups taking soybean. In conclusion, the present study suggests that soybean supplementation is capable of stimulating ALP production and reducing cartilage loss in young female mice. Soybean supplementation during childhood may therefore be potentially useful in protecting joints. Copyright © 2010 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.3327 |
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Forty female mice were fed for 6 months on one of four regimens: low protein, complete protein without soybean, and complete protein containing either 20% or 40% soybean. Body weight differences, histological and histomorphometric analysis, and ALP levels were determined and compared after 6 months. The results showed a significant increase in serum ALP activity and cartilage thickness in both groups fed on soybean‐containing diets, compared with the other groups. Additionally, the number of chondrocytes was significantly increased (p < 0.001) in the group taking the 40% soybean regimen, and the proteoglycan content of the intracellular fluid in the tibia was higher in those groups taking soybean. In conclusion, the present study suggests that soybean supplementation is capable of stimulating ALP production and reducing cartilage loss in young female mice. Soybean supplementation during childhood may therefore be potentially useful in protecting joints. Copyright © 2010 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>ISSN: 1099-1573</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.3327</identifier><identifier>PMID: 21110395</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>alkaline phosphatase ; Alkaline Phosphatase - blood ; Animals ; Antirheumatic Agents - therapeutic use ; Biological and medical sciences ; cartilage ; Cartilage, Articular - drug effects ; Cartilage, Articular - metabolism ; Dietary Supplements ; Female ; General pharmacology ; histomorphometric ; Humans ; Indexing in process ; Knee Joint - cytology ; Knee Joint - drug effects ; Knee Joint - pathology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Models, Animal ; Osteoarthritis, Knee - diet therapy ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Protective Agents - pharmacology ; soybean ; Soybean Proteins - pharmacology</subject><ispartof>Phytotherapy research, 2011-06, Vol.25 (6), p.886-891</ispartof><rights>Copyright © 2010 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4217-7124c2eb6846e4a72114d1f3cf4295cbe48b5fe8f5e429d43df904eabd13d5da3</citedby><cites>FETCH-LOGICAL-c4217-7124c2eb6846e4a72114d1f3cf4295cbe48b5fe8f5e429d43df904eabd13d5da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.3327$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.3327$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24222777$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21110395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fazelipour, S.</creatorcontrib><creatorcontrib>Tootian, Z.</creatorcontrib><creatorcontrib>Matini, E.</creatorcontrib><creatorcontrib>Hadipour-Jahromy, M.</creatorcontrib><title>Histomorphometric alteration of knee articular cartilage and serum alkaline phosphatase in young female mice by chronic supplementation with soybean</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The purpose of the present study was to examine the effect of soybean supplementation on cartilage thickness in the knee joint and serum levels of alkaline phosphatase (ALP) in mice. Forty female mice were fed for 6 months on one of four regimens: low protein, complete protein without soybean, and complete protein containing either 20% or 40% soybean. Body weight differences, histological and histomorphometric analysis, and ALP levels were determined and compared after 6 months. The results showed a significant increase in serum ALP activity and cartilage thickness in both groups fed on soybean‐containing diets, compared with the other groups. Additionally, the number of chondrocytes was significantly increased (p < 0.001) in the group taking the 40% soybean regimen, and the proteoglycan content of the intracellular fluid in the tibia was higher in those groups taking soybean. In conclusion, the present study suggests that soybean supplementation is capable of stimulating ALP production and reducing cartilage loss in young female mice. Soybean supplementation during childhood may therefore be potentially useful in protecting joints. Copyright © 2010 John Wiley & Sons, Ltd.</description><subject>alkaline phosphatase</subject><subject>Alkaline Phosphatase - blood</subject><subject>Animals</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>cartilage</subject><subject>Cartilage, Articular - drug effects</subject><subject>Cartilage, Articular - metabolism</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>General pharmacology</subject><subject>histomorphometric</subject><subject>Humans</subject><subject>Indexing in process</subject><subject>Knee Joint - cytology</subject><subject>Knee Joint - drug effects</subject><subject>Knee Joint - pathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Models, Animal</subject><subject>Osteoarthritis, Knee - diet therapy</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Protective Agents - pharmacology</subject><subject>soybean</subject><subject>Soybean Proteins - pharmacology</subject><issn>0951-418X</issn><issn>1099-1573</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURSMEotOCxBcgbxBsUmzHmSRLVNEWqUBVFcrOenGeO2YcO9iJ2vwHH4xHE9oVrGw9nXev7JNlrxg9ZpTy98MYjouCV0-yFaNNk7OyKp5mK9qULBes_nGQHcb4k1LacCqeZwecMUaLplxlv89NHH3vw7DxPY7BKAJ2xACj8Y54TbYOkUAYjZosBKJ2Vwu3aeY6EjFMfVrYgjUOScqIwwZGiEiMI7Of3C3R2INF0huFpJ2J2gTvUkuchsFij27cV92ZcUOin1sE9yJ7psFGfLmcR9m304_XJ-f5xdezTycfLnIlOKvyinGhOLbrWqxRQJVeJTqmC6UFb0rVoqjbUmOtS0yDThSdbqhAaDtWdGUHxVH2dp87BP9rwjjK3kSF1oJDP0VZr5uyEZyuE_nuv2T69UKUtKrrR1QFH2NALYdgeghzguTOlky25M5WQl8vqVPbY_cA_tWTgDcLAFGB1QGcMvGRE5zzqtoF5Xvuzlic_1koL6-vluKFT_Lx_oGHsJXrqqhKefPlTJ5efuc39OpzWv0D4-y-Ug</recordid><startdate>201106</startdate><enddate>201106</enddate><creator>Fazelipour, S.</creator><creator>Tootian, Z.</creator><creator>Matini, E.</creator><creator>Hadipour-Jahromy, M.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201106</creationdate><title>Histomorphometric alteration of knee articular cartilage and serum alkaline phosphatase in young female mice by chronic supplementation with soybean</title><author>Fazelipour, S. ; Tootian, Z. ; Matini, E. ; Hadipour-Jahromy, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4217-7124c2eb6846e4a72114d1f3cf4295cbe48b5fe8f5e429d43df904eabd13d5da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>alkaline phosphatase</topic><topic>Alkaline Phosphatase - blood</topic><topic>Animals</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>cartilage</topic><topic>Cartilage, Articular - drug effects</topic><topic>Cartilage, Articular - metabolism</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>General pharmacology</topic><topic>histomorphometric</topic><topic>Humans</topic><topic>Indexing in process</topic><topic>Knee Joint - cytology</topic><topic>Knee Joint - drug effects</topic><topic>Knee Joint - pathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Models, Animal</topic><topic>Osteoarthritis, Knee - diet therapy</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Protective Agents - pharmacology</topic><topic>soybean</topic><topic>Soybean Proteins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fazelipour, S.</creatorcontrib><creatorcontrib>Tootian, Z.</creatorcontrib><creatorcontrib>Matini, E.</creatorcontrib><creatorcontrib>Hadipour-Jahromy, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fazelipour, S.</au><au>Tootian, Z.</au><au>Matini, E.</au><au>Hadipour-Jahromy, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histomorphometric alteration of knee articular cartilage and serum alkaline phosphatase in young female mice by chronic supplementation with soybean</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2011-06</date><risdate>2011</risdate><volume>25</volume><issue>6</issue><spage>886</spage><epage>891</epage><pages>886-891</pages><issn>0951-418X</issn><issn>1099-1573</issn><eissn>1099-1573</eissn><abstract>The purpose of the present study was to examine the effect of soybean supplementation on cartilage thickness in the knee joint and serum levels of alkaline phosphatase (ALP) in mice. Forty female mice were fed for 6 months on one of four regimens: low protein, complete protein without soybean, and complete protein containing either 20% or 40% soybean. Body weight differences, histological and histomorphometric analysis, and ALP levels were determined and compared after 6 months. The results showed a significant increase in serum ALP activity and cartilage thickness in both groups fed on soybean‐containing diets, compared with the other groups. Additionally, the number of chondrocytes was significantly increased (p < 0.001) in the group taking the 40% soybean regimen, and the proteoglycan content of the intracellular fluid in the tibia was higher in those groups taking soybean. In conclusion, the present study suggests that soybean supplementation is capable of stimulating ALP production and reducing cartilage loss in young female mice. Soybean supplementation during childhood may therefore be potentially useful in protecting joints. Copyright © 2010 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>21110395</pmid><doi>10.1002/ptr.3327</doi><tpages>6</tpages></addata></record> |
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| subjects | alkaline phosphatase Alkaline Phosphatase - blood Animals Antirheumatic Agents - therapeutic use Biological and medical sciences cartilage Cartilage, Articular - drug effects Cartilage, Articular - metabolism Dietary Supplements Female General pharmacology histomorphometric Humans Indexing in process Knee Joint - cytology Knee Joint - drug effects Knee Joint - pathology Medical sciences Mice Mice, Inbred BALB C Models, Animal Osteoarthritis, Knee - diet therapy Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Protective Agents - pharmacology soybean Soybean Proteins - pharmacology |
| title | Histomorphometric alteration of knee articular cartilage and serum alkaline phosphatase in young female mice by chronic supplementation with soybean |
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