Gp96 SIVIg immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa

The ER-resident chaperone gp96, when released by cell lysis, induces an immunogenic chemokine signature and causes innate immune activation of DC and NK cells. Here we show that intraperitoneal immunization with a genetically engineered, secreted form of gp96, gp96-Ig chaperoning SIV antigens, induc...

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Veröffentlicht in:	Vaccine 2011-03, Vol.29 (14), p.2619-2625
Hauptverfasser:	Strbo, Natasa, Vaccari, Monica, Pahwa, Savita, Kolber, Michael A., Fisher, Eva, Gonzalez, Louis, Doster, Melvin N., Hryniewicz, Anna, Felber, Barbara K., Pavlakis, George N., Franchini, Genoveffa, Podack, Eckhard R.
Format:	Artikel
Sprache:	eng
Schlagworte:	gp96-chaperone Human immunodeficiency virus Macaca mulatta Mucosa Non-human primate Rectum Simian immunodeficiency virus Vagina
Online-Zugang:	Volltext
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