Expression of alpha5 integrin rescues fibronectin responsiveness in NT2N CNS neuronal cells

The extracellular matrix protein fibronectin is implicated in neuronal regeneration in the peripheral nervous system. In the central nervous system (CNS), fibronectin is up-regulated at sites of penetrating injuries and stroke; however, CNS neurons down-regulate the fibronectin receptor alpha5beta1...

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Veröffentlicht in:	Journal of neuroscience research 2010-01, Vol.88 (1), p.222-232
Hauptverfasser:	Meland, Marit N, Herndon, Mary E, Stipp, Christopher S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion Cell Line Extracellular Matrix - drug effects Extracellular Matrix - metabolism Fibronectins - metabolism Fibronectins - pharmacology Fluorescent Antibody Technique Gene Expression Genetic Vectors Image Processing, Computer-Assisted Immunoprecipitation Integrin alpha5 - genetics Integrin alpha5 - metabolism Lentivirus - metabolism Neurites - drug effects Neurites - metabolism Neurogenesis - physiology Neurons - drug effects Neurons - metabolism Transfection
Online-Zugang:	Volltext
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