Response of plasma bone markers to a single intramuscular administration of calcitriol in dairy cows
To elucidate the effects of an exogenous calcitriol (1,25-dihydroxyvitamin D 3) on plasma bone markers, the formation item osteocalcin (OC), undercarboxylated OC (ucOC) and bone-specific alkaline phosphatase (BALP), and the resorption parameter tartrate-resistant acid phosphatase isoform 5b (TRAP5b)...
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| Veröffentlicht in: | Research in veterinary science 2011-02, Vol.90 (1), p.124-126 |
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| creator | Kim, Danil Kawakami, Yuji Yamagishi, Norio Abe, Izumi Furuhama, Kazuhisa Devkota, Bhuminand Okura, Norimoto Sato, Shigeru Ohashi, Shuichi |
| description | To elucidate the effects of an exogenous calcitriol (1,25-dihydroxyvitamin D
3) on plasma bone markers, the formation item osteocalcin (OC), undercarboxylated OC (ucOC) and bone-specific alkaline phosphatase (BALP), and the resorption parameter tartrate-resistant acid phosphatase isoform 5b (TRAP5b) and hydroxyproline (HYP) were measured in conjunction with plasma calcitriol and calcium (Ca) concentrations in dairy cows receiving calcitriol or its vehicle according to a 2
×
2 crossover design. Calcitriol (0.5
μg/kg, i.m.) increased significantly its plasma level during 6
h to day 2 and plasma Ca concentration during 12
h to day 7 compared to the vehicle. Also, plasma OC and ucOC started to rise from day 3 and 1, respectively, and remained elevated until day 7. No change in plasma BALP, TRAP5b or HYP associated with calcitriol treatment was noted. These results demonstrate that exogenous calcitriol stimulates osteoblasts to biosynthesise OC, a determinant of the bone formation in cows. |
| doi_str_mv | 10.1016/j.rvsc.2010.05.007 |
| format | Article |
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3) on plasma bone markers, the formation item osteocalcin (OC), undercarboxylated OC (ucOC) and bone-specific alkaline phosphatase (BALP), and the resorption parameter tartrate-resistant acid phosphatase isoform 5b (TRAP5b) and hydroxyproline (HYP) were measured in conjunction with plasma calcitriol and calcium (Ca) concentrations in dairy cows receiving calcitriol or its vehicle according to a 2
×
2 crossover design. Calcitriol (0.5
μg/kg, i.m.) increased significantly its plasma level during 6
h to day 2 and plasma Ca concentration during 12
h to day 7 compared to the vehicle. Also, plasma OC and ucOC started to rise from day 3 and 1, respectively, and remained elevated until day 7. No change in plasma BALP, TRAP5b or HYP associated with calcitriol treatment was noted. These results demonstrate that exogenous calcitriol stimulates osteoblasts to biosynthesise OC, a determinant of the bone formation in cows.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2010.05.007</identifier><identifier>PMID: 20553702</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Acid Phosphatase - blood ; Acid Phosphatase - metabolism ; Alkaline Phosphatase - blood ; Alkaline Phosphatase - metabolism ; Animals ; Biomarkers - blood ; blood chemistry ; blood plasma ; Bone and Bones - drug effects ; Bone and Bones - metabolism ; bone markers ; bone metabolism ; Bones ; calcitriol ; Calcitriol (1,25-dihydroxyvitamin D 3) ; Calcitriol - blood ; Calcitriol - pharmacology ; Calcium ; Calcium - blood ; Cattle - blood ; Cross-Over Studies ; Dairy cows ; Dairying ; Female ; Hydroxyproline - blood ; Hydroxyproline - metabolism ; Injections, Intramuscular ; intramuscular injection ; Isoenzymes - blood ; Isoenzymes - metabolism ; Metabolic disorders ; Osteocalcin ; Plasma ; Plasma bone metabolic marker ; Tartrate-Resistant Acid Phosphatase ; Veterinary medicine ; Vitamin D</subject><ispartof>Research in veterinary science, 2011-02, Vol.90 (1), p.124-126</ispartof><rights>2010 Elsevier Ltd</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-f7373cf4d2119a70ac6a7d1e0a7ba4fcdfee2bca4f5cb0c369d29d3468383bc43</citedby><cites>FETCH-LOGICAL-c505t-f7373cf4d2119a70ac6a7d1e0a7ba4fcdfee2bca4f5cb0c369d29d3468383bc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rvsc.2010.05.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20553702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Danil</creatorcontrib><creatorcontrib>Kawakami, Yuji</creatorcontrib><creatorcontrib>Yamagishi, Norio</creatorcontrib><creatorcontrib>Abe, Izumi</creatorcontrib><creatorcontrib>Furuhama, Kazuhisa</creatorcontrib><creatorcontrib>Devkota, Bhuminand</creatorcontrib><creatorcontrib>Okura, Norimoto</creatorcontrib><creatorcontrib>Sato, Shigeru</creatorcontrib><creatorcontrib>Ohashi, Shuichi</creatorcontrib><title>Response of plasma bone markers to a single intramuscular administration of calcitriol in dairy cows</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>To elucidate the effects of an exogenous calcitriol (1,25-dihydroxyvitamin D
3) on plasma bone markers, the formation item osteocalcin (OC), undercarboxylated OC (ucOC) and bone-specific alkaline phosphatase (BALP), and the resorption parameter tartrate-resistant acid phosphatase isoform 5b (TRAP5b) and hydroxyproline (HYP) were measured in conjunction with plasma calcitriol and calcium (Ca) concentrations in dairy cows receiving calcitriol or its vehicle according to a 2
×
2 crossover design. Calcitriol (0.5
μg/kg, i.m.) increased significantly its plasma level during 6
h to day 2 and plasma Ca concentration during 12
h to day 7 compared to the vehicle. Also, plasma OC and ucOC started to rise from day 3 and 1, respectively, and remained elevated until day 7. No change in plasma BALP, TRAP5b or HYP associated with calcitriol treatment was noted. These results demonstrate that exogenous calcitriol stimulates osteoblasts to biosynthesise OC, a determinant of the bone formation in cows.</description><subject>Acid Phosphatase - blood</subject><subject>Acid Phosphatase - metabolism</subject><subject>Alkaline Phosphatase - blood</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Biomarkers - blood</subject><subject>blood chemistry</subject><subject>blood plasma</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - metabolism</subject><subject>bone markers</subject><subject>bone metabolism</subject><subject>Bones</subject><subject>calcitriol</subject><subject>Calcitriol (1,25-dihydroxyvitamin D 3)</subject><subject>Calcitriol - blood</subject><subject>Calcitriol - pharmacology</subject><subject>Calcium</subject><subject>Calcium - blood</subject><subject>Cattle - blood</subject><subject>Cross-Over Studies</subject><subject>Dairy cows</subject><subject>Dairying</subject><subject>Female</subject><subject>Hydroxyproline - blood</subject><subject>Hydroxyproline - metabolism</subject><subject>Injections, Intramuscular</subject><subject>intramuscular injection</subject><subject>Isoenzymes - blood</subject><subject>Isoenzymes - metabolism</subject><subject>Metabolic disorders</subject><subject>Osteocalcin</subject><subject>Plasma</subject><subject>Plasma bone metabolic marker</subject><subject>Tartrate-Resistant Acid Phosphatase</subject><subject>Veterinary medicine</subject><subject>Vitamin D</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERZfCH-AAljhwyjK243xIXKqKj0qVkICeLceeVF4Se_EkRf339WoLBw70NNboed8Zz8vYKwFbAaJ5v9vmW3JbCaUBegvQPmEboZWsZNOIp2wDoOpKy647Zc-JdgBQC9E-Y6cStFYtyA3z35D2KRLyNPL9ZGm2fEgR-WzzT8zEl8QtpxBvJuQhLtnOK7l1splbP4cYqLSWkOJB7-zkwpJDmgrKvQ35jrv0m16wk9FOhC8f6hm7_vTxx8WX6urr58uL86vKadBLNbaqVW6svRSity1Y19jWCwTbDrYenR8R5eDKU7sBnGp6L3uv6qZTnRpcrc7Yu6PvPqdfK9Ji5kAOp8lGTCuZrul11zWFf5RUuuwgoS_k23_IXVpzLN8wApSGGkQvCiWPlMuJKONo9jmUE94VyBzCMjtzCMscwjKgTQmriF4_WK_DjP6v5E86BXhzBEabjL3Jgcz19-KgykzZt3VTiA9HAstZbwNmQy5gdOhDRrcYn8L_NrgHxI2v2w</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Kim, Danil</creator><creator>Kawakami, Yuji</creator><creator>Yamagishi, Norio</creator><creator>Abe, Izumi</creator><creator>Furuhama, Kazuhisa</creator><creator>Devkota, Bhuminand</creator><creator>Okura, Norimoto</creator><creator>Sato, Shigeru</creator><creator>Ohashi, Shuichi</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Response of plasma bone markers to a single intramuscular administration of calcitriol in dairy cows</title><author>Kim, Danil ; Kawakami, Yuji ; Yamagishi, Norio ; Abe, Izumi ; Furuhama, Kazuhisa ; Devkota, Bhuminand ; Okura, Norimoto ; Sato, Shigeru ; Ohashi, Shuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-f7373cf4d2119a70ac6a7d1e0a7ba4fcdfee2bca4f5cb0c369d29d3468383bc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acid Phosphatase - blood</topic><topic>Acid Phosphatase - metabolism</topic><topic>Alkaline Phosphatase - blood</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Biomarkers - blood</topic><topic>blood chemistry</topic><topic>blood plasma</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - metabolism</topic><topic>bone markers</topic><topic>bone metabolism</topic><topic>Bones</topic><topic>calcitriol</topic><topic>Calcitriol (1,25-dihydroxyvitamin D 3)</topic><topic>Calcitriol - blood</topic><topic>Calcitriol - pharmacology</topic><topic>Calcium</topic><topic>Calcium - blood</topic><topic>Cattle - blood</topic><topic>Cross-Over Studies</topic><topic>Dairy cows</topic><topic>Dairying</topic><topic>Female</topic><topic>Hydroxyproline - blood</topic><topic>Hydroxyproline - metabolism</topic><topic>Injections, Intramuscular</topic><topic>intramuscular injection</topic><topic>Isoenzymes - blood</topic><topic>Isoenzymes - metabolism</topic><topic>Metabolic disorders</topic><topic>Osteocalcin</topic><topic>Plasma</topic><topic>Plasma bone metabolic marker</topic><topic>Tartrate-Resistant Acid Phosphatase</topic><topic>Veterinary medicine</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Danil</creatorcontrib><creatorcontrib>Kawakami, Yuji</creatorcontrib><creatorcontrib>Yamagishi, Norio</creatorcontrib><creatorcontrib>Abe, Izumi</creatorcontrib><creatorcontrib>Furuhama, Kazuhisa</creatorcontrib><creatorcontrib>Devkota, Bhuminand</creatorcontrib><creatorcontrib>Okura, Norimoto</creatorcontrib><creatorcontrib>Sato, Shigeru</creatorcontrib><creatorcontrib>Ohashi, Shuichi</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Danil</au><au>Kawakami, Yuji</au><au>Yamagishi, Norio</au><au>Abe, Izumi</au><au>Furuhama, Kazuhisa</au><au>Devkota, Bhuminand</au><au>Okura, Norimoto</au><au>Sato, Shigeru</au><au>Ohashi, Shuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response of plasma bone markers to a single intramuscular administration of calcitriol in dairy cows</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>90</volume><issue>1</issue><spage>124</spage><epage>126</epage><pages>124-126</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>To elucidate the effects of an exogenous calcitriol (1,25-dihydroxyvitamin D
3) on plasma bone markers, the formation item osteocalcin (OC), undercarboxylated OC (ucOC) and bone-specific alkaline phosphatase (BALP), and the resorption parameter tartrate-resistant acid phosphatase isoform 5b (TRAP5b) and hydroxyproline (HYP) were measured in conjunction with plasma calcitriol and calcium (Ca) concentrations in dairy cows receiving calcitriol or its vehicle according to a 2
×
2 crossover design. Calcitriol (0.5
μg/kg, i.m.) increased significantly its plasma level during 6
h to day 2 and plasma Ca concentration during 12
h to day 7 compared to the vehicle. Also, plasma OC and ucOC started to rise from day 3 and 1, respectively, and remained elevated until day 7. No change in plasma BALP, TRAP5b or HYP associated with calcitriol treatment was noted. These results demonstrate that exogenous calcitriol stimulates osteoblasts to biosynthesise OC, a determinant of the bone formation in cows.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>20553702</pmid><doi>10.1016/j.rvsc.2010.05.007</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0034-5288 |
| ispartof | Research in veterinary science, 2011-02, Vol.90 (1), p.124-126 |
| issn | 0034-5288 1532-2661 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_869588668 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acid Phosphatase - blood Acid Phosphatase - metabolism Alkaline Phosphatase - blood Alkaline Phosphatase - metabolism Animals Biomarkers - blood blood chemistry blood plasma Bone and Bones - drug effects Bone and Bones - metabolism bone markers bone metabolism Bones calcitriol Calcitriol (1,25-dihydroxyvitamin D 3) Calcitriol - blood Calcitriol - pharmacology Calcium Calcium - blood Cattle - blood Cross-Over Studies Dairy cows Dairying Female Hydroxyproline - blood Hydroxyproline - metabolism Injections, Intramuscular intramuscular injection Isoenzymes - blood Isoenzymes - metabolism Metabolic disorders Osteocalcin Plasma Plasma bone metabolic marker Tartrate-Resistant Acid Phosphatase Veterinary medicine Vitamin D |
| title | Response of plasma bone markers to a single intramuscular administration of calcitriol in dairy cows |
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