Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes

Background Atopic dermatitis (AD) is a chronic inflammatory skin disorder caused by multiple factors. Among them, house dust mite (HDM) allergens are important in the development of AD. In airway allergy, HDM allergens activate innate immunity. However, information regarding the activation of innate...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2011-03, Vol.127 (3), p.806-814.e4
Hauptverfasser:	Dai, Xiuju, MD, PhD, Sayama, Koji, MD, PhD, Tohyama, Mikiko, MD, PhD, Shirakata, Yuji, MD, PhD, Hanakawa, Yasushi, MD, PhD, Tokumaru, Sho, MD, PhD, Yang, Lujun, MD, PhD, Hirakawa, Satoshi, MD, PhD, Hashimoto, Koji, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Allergy and Immunology Animals Antigens, Dermatophagoides - metabolism Antigens, Dermatophagoides - pharmacology Asthma Biological and medical sciences caspase-1 Cells, Cultured Cytokines Der p 1 Dermatophagoides pteronyssinus Dermatophagoides pteronyssinus - immunology Experiments Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression house dust mite Human subjects Humans IL-18 IL-1β Immunopathology inflammasome Inflammasomes - drug effects Interleukin-1beta - immunology Interleukin-8 - immunology Keratinocytes Keratinocytes - drug effects Keratinocytes - immunology Kinases Medical sciences NLRP3 Pathogenesis Proteins Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin - drug effects Skin - immunology
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