ATP-loaded liposomes for treatment of myocardial ischemia
A major obstacle to drug therapy for treatment of potential myocardial infarction is the limited access to the ischemic myocardium by drugs in an active form. Encouraging results have been reported with liposomes loaded with ATP in a variety of in vitro and in vivo models. We describe methods for op...
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| Veröffentlicht in: | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2009-09, Vol.1 (5), p.530-539 |
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| creator | Hartner, William C. Verma, Daya D. Levchenko, Tatyana S. Bernstein, Eugene A. Torchilin, Vladimir P. |
| description | A major obstacle to drug therapy for treatment of potential myocardial infarction is the limited access to the ischemic myocardium by drugs in an active form. Encouraging results have been reported with liposomes loaded with ATP in a variety of in vitro and in vivo models. We describe methods for optimized encapsulation of ATP in liposomes, enhancement of their effectiveness by increasing circulation time, and targeting of injured myocardial cells with surface attached antimyosin. In isolated ischemic rat hearts, ATP‐loaded liposomes and ATP‐loaded immunoliposomes effectively protected myocardium from ischemia/reperfusion damage as measured by systolic and diastolic functional improvements. In vivo, in rabbits with induced localized myocardial ischemia, liposomal encapsulation of ATP significantly diminished the proportion of ventricular muscle at risk that was irreversibly damaged during reperfusion. Therefore, ATP encapsulated in liposomes can provide an effective exogenous source for in vivo application which can protect ischemically damaged hearts. Copyright © 2009 John Wiley & Sons, Inc.
This article is categorized under:
Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease |
| doi_str_mv | 10.1002/wnan.46 |
| format | Article |
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This article is categorized under:
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This article is categorized under:
Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease</description><subject>Adenosine Triphosphate - administration & dosage</subject><subject>Adenosine Triphosphate - chemistry</subject><subject>Animals</subject><subject>Drug Delivery Systems - methods</subject><subject>Humans</subject><subject>Liposomes - administration & dosage</subject><subject>Liposomes - chemistry</subject><subject>Myocardial Ischemia - drug therapy</subject><issn>1939-5116</issn><issn>1939-0041</issn><issn>1939-0041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1PwjAAxvHGaATR-A3Mbh7MsN36eiQoaET0gC-3prRdnG4rtiPIt3e8iCfjqT388k_7AHCKYBdBmFwuKlV1Md0DbSRSEUOI0f72ThCiLXAUwjuEFNOEHIJW0gDBEWkD0Zs8xoVTxpqoyGcuuNKGKHM-qr1VdWmrOnJZVC6dVt7kqojyoN9smatjcJCpItiT7dkBT4PrSf8mHj0Mb_u9UaxJQmmsIOaaoWmiGVZIccaNZYnmmWEMCowzrIRNNCbIZikSzCCiDNZ6ygUTVMG0A8433Zl3n3Mbalk2T7BFoSrr5kFyKggnzc_-lSxNqcBUiF-pvQvB20zOfF4qv5QIytWgcjWoXDfPts35tLRm534WbMDFBizywi7_6siXcW-8zsUbnYfafu208h-SspSRxg3ls3i94oPJvbxLvwF9uY06</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Hartner, William C.</creator><creator>Verma, Daya D.</creator><creator>Levchenko, Tatyana S.</creator><creator>Bernstein, Eugene A.</creator><creator>Torchilin, Vladimir P.</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>200909</creationdate><title>ATP-loaded liposomes for treatment of myocardial ischemia</title><author>Hartner, William C. ; Verma, Daya D. ; Levchenko, Tatyana S. ; Bernstein, Eugene A. ; Torchilin, Vladimir P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5266-a048c71b2c74a1a878de72c8fd770944f4a9e2c451ef3197d15ad4ccb89796a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenosine Triphosphate - administration & dosage</topic><topic>Adenosine Triphosphate - chemistry</topic><topic>Animals</topic><topic>Drug Delivery Systems - methods</topic><topic>Humans</topic><topic>Liposomes - administration & dosage</topic><topic>Liposomes - chemistry</topic><topic>Myocardial Ischemia - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hartner, William C.</creatorcontrib><creatorcontrib>Verma, Daya D.</creatorcontrib><creatorcontrib>Levchenko, Tatyana S.</creatorcontrib><creatorcontrib>Bernstein, Eugene A.</creatorcontrib><creatorcontrib>Torchilin, Vladimir P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Wiley interdisciplinary reviews. 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Encouraging results have been reported with liposomes loaded with ATP in a variety of in vitro and in vivo models. We describe methods for optimized encapsulation of ATP in liposomes, enhancement of their effectiveness by increasing circulation time, and targeting of injured myocardial cells with surface attached antimyosin. In isolated ischemic rat hearts, ATP‐loaded liposomes and ATP‐loaded immunoliposomes effectively protected myocardium from ischemia/reperfusion damage as measured by systolic and diastolic functional improvements. In vivo, in rabbits with induced localized myocardial ischemia, liposomal encapsulation of ATP significantly diminished the proportion of ventricular muscle at risk that was irreversibly damaged during reperfusion. Therefore, ATP encapsulated in liposomes can provide an effective exogenous source for in vivo application which can protect ischemically damaged hearts. Copyright © 2009 John Wiley & Sons, Inc.
This article is categorized under:
Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>20049815</pmid><doi>10.1002/wnan.46</doi><tpages>10</tpages></addata></record> |
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| issn | 1939-5116 1939-0041 1939-0041 |
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| subjects | Adenosine Triphosphate - administration & dosage Adenosine Triphosphate - chemistry Animals Drug Delivery Systems - methods Humans Liposomes - administration & dosage Liposomes - chemistry Myocardial Ischemia - drug therapy |
| title | ATP-loaded liposomes for treatment of myocardial ischemia |
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