Evaluation of in vitro antagonism and of in vivo immune modulation and protection against pathogenic experimental challenge of two probiotic strains of Bifidobacterium animalis var. lactis
The aim of the present study was to compare the effect of intragastric administration with two strains of Bifidobacterium animalis subsp. lactis (Bifido A and Bifido B), in gnotobiotic and conventional mice, challenged with Salmonella Typhimurium. In vitro antagonism test showed that the two strains...
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| Veröffentlicht in: | Archives of microbiology 2010-12, Vol.192 (12), p.995-1003 |
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| creator | Martins, Ariane K. S Martins, Flaviano S Gomes, Danielle A Elian, Samir D. A Vieira, Angélica T Teixeira, Mauro M Cara, Denise C Nardi, Regina M. D Nicoli, Jacques R |
| description | The aim of the present study was to compare the effect of intragastric administration with two strains of Bifidobacterium animalis subsp. lactis (Bifido A and Bifido B), in gnotobiotic and conventional mice, challenged with Salmonella Typhimurium. In vitro antagonism test showed that the two strains were able to produce antagonistic substances against various pathogenic microorganisms. In an ex vivo antagonism test the production of antagonistic substances was observed only against three out ten pathogens tested. Both Bifidobacterium strains were able to colonize and to maintain high population levels in the digestive tract of gnotobiotic mice. In addition, the two strains had low and limited translocation ability and did not cause any histological lesion in any of the organs analyzed. Both strains were able to reduce the fecal number of Salmonella in gnotobiotic mice challenged with the pathogen, but only Bifido B was able to confer a protection as demonstrated by a lower mortality. Higher levels of sIgA and IL-10 were observed only in Bifido B mono-associated mice when compared to germ free group. We could conclude that, among the parameters analyzed, the strain Bifido B exhibited the more desirable characteristics to be used as a probiotic. |
| doi_str_mv | 10.1007/s00203-010-0626-0 |
| format | Article |
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S ; Martins, Flaviano S ; Gomes, Danielle A ; Elian, Samir D. A ; Vieira, Angélica T ; Teixeira, Mauro M ; Cara, Denise C ; Nardi, Regina M. D ; Nicoli, Jacques R</creator><creatorcontrib>Martins, Ariane K. S ; Martins, Flaviano S ; Gomes, Danielle A ; Elian, Samir D. A ; Vieira, Angélica T ; Teixeira, Mauro M ; Cara, Denise C ; Nardi, Regina M. D ; Nicoli, Jacques R</creatorcontrib><description>The aim of the present study was to compare the effect of intragastric administration with two strains of Bifidobacterium animalis subsp. lactis (Bifido A and Bifido B), in gnotobiotic and conventional mice, challenged with Salmonella Typhimurium. In vitro antagonism test showed that the two strains were able to produce antagonistic substances against various pathogenic microorganisms. In an ex vivo antagonism test the production of antagonistic substances was observed only against three out ten pathogens tested. Both Bifidobacterium strains were able to colonize and to maintain high population levels in the digestive tract of gnotobiotic mice. In addition, the two strains had low and limited translocation ability and did not cause any histological lesion in any of the organs analyzed. Both strains were able to reduce the fecal number of Salmonella in gnotobiotic mice challenged with the pathogen, but only Bifido B was able to confer a protection as demonstrated by a lower mortality. Higher levels of sIgA and IL-10 were observed only in Bifido B mono-associated mice when compared to germ free group. We could conclude that, among the parameters analyzed, the strain Bifido B exhibited the more desirable characteristics to be used as a probiotic.</description><identifier>ISSN: 0302-8933</identifier><identifier>EISSN: 1432-072X</identifier><identifier>DOI: 10.1007/s00203-010-0626-0</identifier><identifier>PMID: 20848082</identifier><identifier>CODEN: AMICCW</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Animals ; Antagonism ; Antibiosis ; Bacterial Load ; Bacterial Translocation ; Bacteriology ; Bifidobacterium - immunology ; Bifidobacterium animalis ; Bifidobacterium animalis subsp. lactis ; Biochemistry ; Biological and medical sciences ; Biomedical and Life Sciences ; Biotechnology ; Cell Biology ; Digestive tract ; Ecology ; Feces - microbiology ; Fundamental and applied biological sciences. Psychology ; Germ-Free Life ; Gnotobiotics ; IL-10 ; Immunoglobulin A, Secretory - immunology ; Immunomodulation ; Interleukin 10 ; Interleukin-10 - immunology ; Intestines - immunology ; Intestines - microbiology ; Intestines - pathology ; Life Sciences ; Mice ; Microbial Ecology ; Microbiology ; Microorganisms ; Miscellaneous ; Mortality ; Original Paper ; Pathogens ; Population levels ; Probiotics ; Salmonella enterica subsp. enterica serovar Typhimurium ; Salmonella Infections - immunology ; Salmonella typhimurium ; Salmonella typhimurium - pathogenicity ; sIgA ; Translocation</subject><ispartof>Archives of microbiology, 2010-12, Vol.192 (12), p.995-1003</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-f4f10afe151afa9197dc395a4e49079bf9bd9f04d01671257d5d17e35dbeaa8f3</citedby><cites>FETCH-LOGICAL-c456t-f4f10afe151afa9197dc395a4e49079bf9bd9f04d01671257d5d17e35dbeaa8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00203-010-0626-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00203-010-0626-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23437018$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20848082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martins, Ariane K. S</creatorcontrib><creatorcontrib>Martins, Flaviano S</creatorcontrib><creatorcontrib>Gomes, Danielle A</creatorcontrib><creatorcontrib>Elian, Samir D. A</creatorcontrib><creatorcontrib>Vieira, Angélica T</creatorcontrib><creatorcontrib>Teixeira, Mauro M</creatorcontrib><creatorcontrib>Cara, Denise C</creatorcontrib><creatorcontrib>Nardi, Regina M. D</creatorcontrib><creatorcontrib>Nicoli, Jacques R</creatorcontrib><title>Evaluation of in vitro antagonism and of in vivo immune modulation and protection against pathogenic experimental challenge of two probiotic strains of Bifidobacterium animalis var. lactis</title><title>Archives of microbiology</title><addtitle>Arch Microbiol</addtitle><addtitle>Arch Microbiol</addtitle><description>The aim of the present study was to compare the effect of intragastric administration with two strains of Bifidobacterium animalis subsp. lactis (Bifido A and Bifido B), in gnotobiotic and conventional mice, challenged with Salmonella Typhimurium. In vitro antagonism test showed that the two strains were able to produce antagonistic substances against various pathogenic microorganisms. In an ex vivo antagonism test the production of antagonistic substances was observed only against three out ten pathogens tested. Both Bifidobacterium strains were able to colonize and to maintain high population levels in the digestive tract of gnotobiotic mice. In addition, the two strains had low and limited translocation ability and did not cause any histological lesion in any of the organs analyzed. Both strains were able to reduce the fecal number of Salmonella in gnotobiotic mice challenged with the pathogen, but only Bifido B was able to confer a protection as demonstrated by a lower mortality. Higher levels of sIgA and IL-10 were observed only in Bifido B mono-associated mice when compared to germ free group. We could conclude that, among the parameters analyzed, the strain Bifido B exhibited the more desirable characteristics to be used as a probiotic.</description><subject>Animals</subject><subject>Antagonism</subject><subject>Antibiosis</subject><subject>Bacterial Load</subject><subject>Bacterial Translocation</subject><subject>Bacteriology</subject><subject>Bifidobacterium - immunology</subject><subject>Bifidobacterium animalis</subject><subject>Bifidobacterium animalis subsp. lactis</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Cell Biology</subject><subject>Digestive tract</subject><subject>Ecology</subject><subject>Feces - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Germ-Free Life</subject><subject>Gnotobiotics</subject><subject>IL-10</subject><subject>Immunoglobulin A, Secretory - immunology</subject><subject>Immunomodulation</subject><subject>Interleukin 10</subject><subject>Interleukin-10 - immunology</subject><subject>Intestines - immunology</subject><subject>Intestines - microbiology</subject><subject>Intestines - pathology</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Microbial Ecology</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Original Paper</subject><subject>Pathogens</subject><subject>Population levels</subject><subject>Probiotics</subject><subject>Salmonella enterica subsp. enterica serovar Typhimurium</subject><subject>Salmonella Infections - immunology</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium - pathogenicity</subject><subject>sIgA</subject><subject>Translocation</subject><issn>0302-8933</issn><issn>1432-072X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkstu1TAQhiMEoofCA7ABCwmxShnbudhLqMpFqsQCKrGzJomdunLig-0c4N14OBzl0EosYOXLfP_v8cwUxVMKZxSgfR0BGPASKJTQsKaEe8WOVpyV0LKv94sdcGClkJyfFI9ivAGgTAjxsDhhICoBgu2KXxcHdAsm62fiDbEzOdgUPME54ehnG6e8HW5DB0_sNC2zJpMfFrfpVmAffNL9dhzRzjGRPaZrP-rZ9kT_2OtgJ51NHemv0Tk9j3p1Td_9qu2sT5mLKazaNfDWGjv4DvuUlcuahZ3Q2UgOGM6Iy_c2Pi4eGHRRPzmup8XVu4sv5x_Ky0_vP56_uSz7qm5SaSpDAY2mNUWDksp26LmssdKVhFZ2RnaDNFANQJuWsrod6oG2mtdDpxGF4afFq803Z_pt0TGpycZeO4ez9ktUopG14EK0_ydz4ZsaapbJF3-RN34Jc_6GErSuoGq5zBDdoD74GIM2ap_LiOGnoqDWEVDbCKg8AmodAQVZ8-xovHSTHm4Vf3qegZdHAGOPzgScexvvOF7xFqjIHNu4mEO5XeEuw3-9_nwTGfQKx5CNrz4zoByopFRyxn8DUCvWbA</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Martins, Ariane K. 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S ; Martins, Flaviano S ; Gomes, Danielle A ; Elian, Samir D. A ; Vieira, Angélica T ; Teixeira, Mauro M ; Cara, Denise C ; Nardi, Regina M. 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Psychology</topic><topic>Germ-Free Life</topic><topic>Gnotobiotics</topic><topic>IL-10</topic><topic>Immunoglobulin A, Secretory - immunology</topic><topic>Immunomodulation</topic><topic>Interleukin 10</topic><topic>Interleukin-10 - immunology</topic><topic>Intestines - immunology</topic><topic>Intestines - microbiology</topic><topic>Intestines - pathology</topic><topic>Life Sciences</topic><topic>Mice</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic><topic>Microorganisms</topic><topic>Miscellaneous</topic><topic>Mortality</topic><topic>Original Paper</topic><topic>Pathogens</topic><topic>Population levels</topic><topic>Probiotics</topic><topic>Salmonella enterica subsp. enterica serovar Typhimurium</topic><topic>Salmonella Infections - immunology</topic><topic>Salmonella typhimurium</topic><topic>Salmonella typhimurium - pathogenicity</topic><topic>sIgA</topic><topic>Translocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martins, Ariane K. 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S</au><au>Martins, Flaviano S</au><au>Gomes, Danielle A</au><au>Elian, Samir D. A</au><au>Vieira, Angélica T</au><au>Teixeira, Mauro M</au><au>Cara, Denise C</au><au>Nardi, Regina M. D</au><au>Nicoli, Jacques R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of in vitro antagonism and of in vivo immune modulation and protection against pathogenic experimental challenge of two probiotic strains of Bifidobacterium animalis var. lactis</atitle><jtitle>Archives of microbiology</jtitle><stitle>Arch Microbiol</stitle><addtitle>Arch Microbiol</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>192</volume><issue>12</issue><spage>995</spage><epage>1003</epage><pages>995-1003</pages><issn>0302-8933</issn><eissn>1432-072X</eissn><coden>AMICCW</coden><abstract>The aim of the present study was to compare the effect of intragastric administration with two strains of Bifidobacterium animalis subsp. lactis (Bifido A and Bifido B), in gnotobiotic and conventional mice, challenged with Salmonella Typhimurium. In vitro antagonism test showed that the two strains were able to produce antagonistic substances against various pathogenic microorganisms. In an ex vivo antagonism test the production of antagonistic substances was observed only against three out ten pathogens tested. Both Bifidobacterium strains were able to colonize and to maintain high population levels in the digestive tract of gnotobiotic mice. In addition, the two strains had low and limited translocation ability and did not cause any histological lesion in any of the organs analyzed. Both strains were able to reduce the fecal number of Salmonella in gnotobiotic mice challenged with the pathogen, but only Bifido B was able to confer a protection as demonstrated by a lower mortality. Higher levels of sIgA and IL-10 were observed only in Bifido B mono-associated mice when compared to germ free group. We could conclude that, among the parameters analyzed, the strain Bifido B exhibited the more desirable characteristics to be used as a probiotic.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>20848082</pmid><doi>10.1007/s00203-010-0626-0</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0302-8933 |
| ispartof | Archives of microbiology, 2010-12, Vol.192 (12), p.995-1003 |
| issn | 0302-8933 1432-072X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antagonism Antibiosis Bacterial Load Bacterial Translocation Bacteriology Bifidobacterium - immunology Bifidobacterium animalis Bifidobacterium animalis subsp. lactis Biochemistry Biological and medical sciences Biomedical and Life Sciences Biotechnology Cell Biology Digestive tract Ecology Feces - microbiology Fundamental and applied biological sciences. Psychology Germ-Free Life Gnotobiotics IL-10 Immunoglobulin A, Secretory - immunology Immunomodulation Interleukin 10 Interleukin-10 - immunology Intestines - immunology Intestines - microbiology Intestines - pathology Life Sciences Mice Microbial Ecology Microbiology Microorganisms Miscellaneous Mortality Original Paper Pathogens Population levels Probiotics Salmonella enterica subsp. enterica serovar Typhimurium Salmonella Infections - immunology Salmonella typhimurium Salmonella typhimurium - pathogenicity sIgA Translocation |
| title | Evaluation of in vitro antagonism and of in vivo immune modulation and protection against pathogenic experimental challenge of two probiotic strains of Bifidobacterium animalis var. lactis |
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