Evaluation of 131I-anti-MIF mAb as a reporter for allograft rejection
Finding a specific agent will be useful for monitoring allorejection in clinic. The macrophage migration inhibitory factor (MIF) was reported to be one of the major cytokines involved in allorejection. In this study, we evaluated whether 131I-anti-MIF mAb could be an efficient imaging reporter for m...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2011-04, Vol.139 (1), p.40-47 |
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| container_title | Clinical immunology (Orlando, Fla.) |
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| creator | Liang, Ting Zhang, Chao Song, Jing Jiang, Shiqin Hao, Jing Hou, Guihua |
| description | Finding a specific agent will be useful for monitoring allorejection in clinic. The macrophage migration inhibitory factor (MIF) was reported to be one of the major cytokines involved in allorejection. In this study, we evaluated whether 131I-anti-MIF mAb could be an efficient imaging reporter for monitoring allorejection. 131I-anti-MIF mAb or control 131I-IgG was injected to skin allotransplantation mice and T/NT ratios were evaluated. The imaging changes of grafts were dynamically displayed by whole-body images. The results showed that up-regulation of MIF expression was found in allografts but not in isografts. During the whole progression of rejection, the T/NT ratio in the 131I-anti-MIF mAb group was significantly higher than that in the 131I-IgG group and markedly increased on the top of rejection. The graft-rejection could also be shown more clearly in the 131I-anti-MIF mAb group by whole-body imaging. These results implied that 131I-anti-MIF mAb may be a valid method for facilitating the development of protocols to monitor allorejection. |
| doi_str_mv | 10.1016/j.clim.2010.12.017 |
| format | Article |
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The macrophage migration inhibitory factor (MIF) was reported to be one of the major cytokines involved in allorejection. In this study, we evaluated whether 131I-anti-MIF mAb could be an efficient imaging reporter for monitoring allorejection. 131I-anti-MIF mAb or control 131I-IgG was injected to skin allotransplantation mice and T/NT ratios were evaluated. The imaging changes of grafts were dynamically displayed by whole-body images. The results showed that up-regulation of MIF expression was found in allografts but not in isografts. During the whole progression of rejection, the T/NT ratio in the 131I-anti-MIF mAb group was significantly higher than that in the 131I-IgG group and markedly increased on the top of rejection. The graft-rejection could also be shown more clearly in the 131I-anti-MIF mAb group by whole-body imaging. These results implied that 131I-anti-MIF mAb may be a valid method for facilitating the development of protocols to monitor allorejection.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2010.12.017</identifier><identifier>PMID: 21273133</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Allograft ; Animals ; Antibodies, Monoclonal - immunology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gene Expression Regulation - immunology ; Graft Rejection - immunology ; Graft Rejection - metabolism ; Imaging ; Iodine Radioisotopes ; Macrophage Migration-Inhibitory Factors - genetics ; Macrophage Migration-Inhibitory Factors - immunology ; Macrophage Migration-Inhibitory Factors - metabolism ; Mice ; MIF ; Rejection ; Skin ; Skin - pathology ; Skin Transplantation - immunology ; Tissue Distribution - immunology</subject><ispartof>Clinical immunology (Orlando, Fla.), 2011-04, Vol.139 (1), p.40-47</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2623-1dcdd456d4ba9666dc30331cf2ba7402fb3d2eede5b8597922aefc8145ab08263</citedby><cites>FETCH-LOGICAL-c2623-1dcdd456d4ba9666dc30331cf2ba7402fb3d2eede5b8597922aefc8145ab08263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1521661610008090$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24081442$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21273133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Ting</creatorcontrib><creatorcontrib>Zhang, Chao</creatorcontrib><creatorcontrib>Song, Jing</creatorcontrib><creatorcontrib>Jiang, Shiqin</creatorcontrib><creatorcontrib>Hao, Jing</creatorcontrib><creatorcontrib>Hou, Guihua</creatorcontrib><title>Evaluation of 131I-anti-MIF mAb as a reporter for allograft rejection</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>Finding a specific agent will be useful for monitoring allorejection in clinic. The macrophage migration inhibitory factor (MIF) was reported to be one of the major cytokines involved in allorejection. In this study, we evaluated whether 131I-anti-MIF mAb could be an efficient imaging reporter for monitoring allorejection. 131I-anti-MIF mAb or control 131I-IgG was injected to skin allotransplantation mice and T/NT ratios were evaluated. The imaging changes of grafts were dynamically displayed by whole-body images. The results showed that up-regulation of MIF expression was found in allografts but not in isografts. During the whole progression of rejection, the T/NT ratio in the 131I-anti-MIF mAb group was significantly higher than that in the 131I-IgG group and markedly increased on the top of rejection. The graft-rejection could also be shown more clearly in the 131I-anti-MIF mAb group by whole-body imaging. These results implied that 131I-anti-MIF mAb may be a valid method for facilitating the development of protocols to monitor allorejection.</description><subject>Allograft</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Expression Regulation - immunology</subject><subject>Graft Rejection - immunology</subject><subject>Graft Rejection - metabolism</subject><subject>Imaging</subject><subject>Iodine Radioisotopes</subject><subject>Macrophage Migration-Inhibitory Factors - genetics</subject><subject>Macrophage Migration-Inhibitory Factors - immunology</subject><subject>Macrophage Migration-Inhibitory Factors - metabolism</subject><subject>Mice</subject><subject>MIF</subject><subject>Rejection</subject><subject>Skin</subject><subject>Skin - pathology</subject><subject>Skin Transplantation - immunology</subject><subject>Tissue Distribution - immunology</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhq2KqlDaF-ihygVxytYex04icUFooStR9QJna2KPkVdJvLWzSH17Eu1Cb_Q01uj7Z8YfY98EXwku9I_tyvZhWAFfGrDiov7AzoQCUdZcqpPjW2uhT9nnnLeccwWgP7FTEFBLIeUZW6-fsd_jFOJYRF8IKTYljlMof21ui-G6KzAXWCTaxTRRKnxMBfZ9fErop7m9JbtEv7CPHvtMX4_1nD3erh9ufpb3v-82N9f3pQUNshTOOlcp7aoOW621s5JLKayHDuuKg--kAyJHqmtUW7cASN42olLY8Qa0PGeXh7m7FP_sKU9mCNlS3-NIcZ9No1vVyKaG_5OqnWVovZBwIG2KOSfyZpfCgOmvEdwsns3WLJ7N4tkIMLPnOfT9OH7fDeTeIq9iZ-DiCGC22PuEow35H1fx-VvVsv3qwNGs7TlQMtkGGi25kGa3xsXw3h0vZ-SZBw</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Liang, Ting</creator><creator>Zhang, Chao</creator><creator>Song, Jing</creator><creator>Jiang, Shiqin</creator><creator>Hao, Jing</creator><creator>Hou, Guihua</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201104</creationdate><title>Evaluation of 131I-anti-MIF mAb as a reporter for allograft rejection</title><author>Liang, Ting ; Zhang, Chao ; Song, Jing ; Jiang, Shiqin ; Hao, Jing ; Hou, Guihua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2623-1dcdd456d4ba9666dc30331cf2ba7402fb3d2eede5b8597922aefc8145ab08263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Allograft</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Expression Regulation - immunology</topic><topic>Graft Rejection - immunology</topic><topic>Graft Rejection - metabolism</topic><topic>Imaging</topic><topic>Iodine Radioisotopes</topic><topic>Macrophage Migration-Inhibitory Factors - genetics</topic><topic>Macrophage Migration-Inhibitory Factors - immunology</topic><topic>Macrophage Migration-Inhibitory Factors - metabolism</topic><topic>Mice</topic><topic>MIF</topic><topic>Rejection</topic><topic>Skin</topic><topic>Skin - pathology</topic><topic>Skin Transplantation - immunology</topic><topic>Tissue Distribution - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Ting</creatorcontrib><creatorcontrib>Zhang, Chao</creatorcontrib><creatorcontrib>Song, Jing</creatorcontrib><creatorcontrib>Jiang, Shiqin</creatorcontrib><creatorcontrib>Hao, Jing</creatorcontrib><creatorcontrib>Hou, Guihua</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Ting</au><au>Zhang, Chao</au><au>Song, Jing</au><au>Jiang, Shiqin</au><au>Hao, Jing</au><au>Hou, Guihua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of 131I-anti-MIF mAb as a reporter for allograft rejection</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2011-04</date><risdate>2011</risdate><volume>139</volume><issue>1</issue><spage>40</spage><epage>47</epage><pages>40-47</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><coden>CLIIFY</coden><abstract>Finding a specific agent will be useful for monitoring allorejection in clinic. The macrophage migration inhibitory factor (MIF) was reported to be one of the major cytokines involved in allorejection. In this study, we evaluated whether 131I-anti-MIF mAb could be an efficient imaging reporter for monitoring allorejection. 131I-anti-MIF mAb or control 131I-IgG was injected to skin allotransplantation mice and T/NT ratios were evaluated. The imaging changes of grafts were dynamically displayed by whole-body images. The results showed that up-regulation of MIF expression was found in allografts but not in isografts. During the whole progression of rejection, the T/NT ratio in the 131I-anti-MIF mAb group was significantly higher than that in the 131I-IgG group and markedly increased on the top of rejection. The graft-rejection could also be shown more clearly in the 131I-anti-MIF mAb group by whole-body imaging. These results implied that 131I-anti-MIF mAb may be a valid method for facilitating the development of protocols to monitor allorejection.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>21273133</pmid><doi>10.1016/j.clim.2010.12.017</doi><tpages>8</tpages></addata></record> |
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| subjects | Allograft Animals Antibodies, Monoclonal - immunology Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation - immunology Graft Rejection - immunology Graft Rejection - metabolism Imaging Iodine Radioisotopes Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - immunology Macrophage Migration-Inhibitory Factors - metabolism Mice MIF Rejection Skin Skin - pathology Skin Transplantation - immunology Tissue Distribution - immunology |
| title | Evaluation of 131I-anti-MIF mAb as a reporter for allograft rejection |
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