Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes

Aconitine (AC), a famous major Aconitum alkaloid, has effective antirheumatic function with high toxicity. The aim of our study was to in-depth investigate cytochrome P450 isozymes (CYPs) involved in aconitine metabolism in vitro. We used human liver microsomes (HLMs) as well as recombinant CYPs to...

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Veröffentlicht in:	Toxicology letters 2011-04, Vol.202 (1), p.47-54
Hauptverfasser:	Tang, Lan, Ye, Ling, Lv, Chang, Zheng, Zhijie, Gong, Yun, Liu, Zhongqiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitine Aconitine - metabolism Aconitine - toxicity Aconitum Adjuvants, Immunologic - metabolism Adjuvants, Immunologic - toxicity Biological and medical sciences Cytochrome P-450 CYP2D6 - metabolism Cytochrome P-450 CYP3A - metabolism Cytochrome P450 Dehydrogenation Human Humans Hydroxylation Inhibitors LC–MS/MS Liver Medical sciences Metabolism Metabolites Microsomes Microsomes, Liver - drug effects Microsomes, Liver - metabolism Recombinant Recombinant Proteins - metabolism Toxicology
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