Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons

Rho family small GTPases are key regulators of morphological changes in neurons. Cdc42, one of the most characterized members of the Rho family of proteins, is involved in axon and dendrite outgrowth through cytoskeletal reorganization. Recent studies have identified Zizimin1, a member of the Dock18...

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Veröffentlicht in:	Journal of neuroscience research 2009-06, Vol.87 (8), p.1794-1805
Hauptverfasser:	Kuramoto, Kazuya, Negishi, Manabu, Katoh, Hironori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - cytology Brain - embryology Brain - growth & development Cdc42 Cell Differentiation - physiology Cell Enlargement Cell Line Cell Membrane - metabolism Cells, Cultured dendrite growth Dendrites - metabolism Dendrites - ultrastructure Dock9 Down-Regulation - genetics Gene Expression Regulation, Developmental - genetics GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism hippocampal neuron Hippocampus - metabolism Hippocampus - ultrastructure Humans membrane localization Mice Neurogenesis - physiology Protein Structure, Tertiary - physiology Rats Rats, Wistar RNA, Small Interfering - genetics Zizimin1
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