Syngas fermentation in a 100-L pilot scale fermentor: Design and process considerations
Fermentation of syngas offers several advantages compared to chemical catalysts such as higher specificity of biocatalysts, lower energy costs, and higher carbon efficiency. Scale-up of syngas fermentation from a bench scale to a pilot scale fermentor is a critical step leading to commercialization....
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| Veröffentlicht in: | Journal of bioscience and bioengineering 2010-05, Vol.109 (5), p.492-498 |
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| creator | Kundiyana, Dimple K. Huhnke, Raymond L. Wilkins, Mark R. |
| description | Fermentation of syngas offers several advantages compared to chemical catalysts such as higher specificity of biocatalysts, lower energy costs, and higher carbon efficiency. Scale-up of syngas fermentation from a bench scale to a pilot scale fermentor is a critical step leading to commercialization. The primary objective of this research was to install and commission a pilot scale fermentor, and subsequently scale-up the
Clostridium strain P11 fermentation from a 7.5-L fermentor to a pilot scale 100-L fermentor. Initial preparation and fermentations were conducted in strictly anaerobic conditions. The fermentation system was maintained in a batch mode with continuous syngas supply. The effect of anaerobic fermentation in a pilot scale fermentor was evaluated. In addition, the impact of improving the syngas mass transfer coefficient on the utilization and product formation was studied. Results indicate a six fold improvement in ethanol concentration compared to serum bottle fermentation, and formation of other compounds such as isopropyl alcohol, acetic acid and butanol, which are of commercial importance. |
| doi_str_mv | 10.1016/j.jbiosc.2009.10.022 |
| format | Article |
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Clostridium strain P11 fermentation from a 7.5-L fermentor to a pilot scale 100-L fermentor. Initial preparation and fermentations were conducted in strictly anaerobic conditions. The fermentation system was maintained in a batch mode with continuous syngas supply. The effect of anaerobic fermentation in a pilot scale fermentor was evaluated. In addition, the impact of improving the syngas mass transfer coefficient on the utilization and product formation was studied. Results indicate a six fold improvement in ethanol concentration compared to serum bottle fermentation, and formation of other compounds such as isopropyl alcohol, acetic acid and butanol, which are of commercial importance.</description><identifier>ISSN: 1389-1723</identifier><identifier>EISSN: 1347-4421</identifier><identifier>DOI: 10.1016/j.jbiosc.2009.10.022</identifier><identifier>PMID: 20347773</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Anaerobic ; ANAEROBIOSE ; ANAEROBIOSIS ; BIOCATALIZADOR ; BIOCATALYSEUR ; BIOCATALYSTS ; Biological and medical sciences ; BIOMASA ; BIOMASS ; BIOMASSE ; Bioreactors ; Bioreactors - microbiology ; Biotechnology ; CLOSTRIDIO ; CLOSTRIDIUM ; Clostridium - metabolism ; Computer Simulation ; Computer-Aided Design ; Equipment Design ; Equipment Failure Analysis ; ETANOL ; ETHANOL ; Ethanol - metabolism ; FERMENTACION ; FERMENTADORES ; FERMENTATION ; Fermentation - physiology ; FERMENTERS ; FERMENTEUR ; Fundamental and applied biological sciences. Psychology ; http://www.fao.org/aos/agrovoc#c_10677 ; http://www.fao.org/aos/agrovoc#c_1680 ; http://www.fao.org/aos/agrovoc#c_23990 ; http://www.fao.org/aos/agrovoc#c_27460 ; http://www.fao.org/aos/agrovoc#c_27522 ; http://www.fao.org/aos/agrovoc#c_2855 ; http://www.fao.org/aos/agrovoc#c_926 ; Methods. Procedures. Technologies ; Microbial engineering. Fermentation and microbial culture technology ; Models, Biological ; Starch - metabolism ; Syngas ; Various methods and equipments</subject><ispartof>Journal of bioscience and bioengineering, 2010-05, Vol.109 (5), p.492-498</ispartof><rights>2009 The Society for Biotechnology, Japan</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2009 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-9acc1d5264c75a8f81b1c9d18d2d1e3e4043b1c0fe2a319972b931b0d462a85f3</citedby><cites>FETCH-LOGICAL-c569t-9acc1d5264c75a8f81b1c9d18d2d1e3e4043b1c0fe2a319972b931b0d462a85f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jbiosc.2009.10.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22842558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20347773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kundiyana, Dimple K.</creatorcontrib><creatorcontrib>Huhnke, Raymond L.</creatorcontrib><creatorcontrib>Wilkins, Mark R.</creatorcontrib><title>Syngas fermentation in a 100-L pilot scale fermentor: Design and process considerations</title><title>Journal of bioscience and bioengineering</title><addtitle>J Biosci Bioeng</addtitle><description>Fermentation of syngas offers several advantages compared to chemical catalysts such as higher specificity of biocatalysts, lower energy costs, and higher carbon efficiency. Scale-up of syngas fermentation from a bench scale to a pilot scale fermentor is a critical step leading to commercialization. The primary objective of this research was to install and commission a pilot scale fermentor, and subsequently scale-up the
Clostridium strain P11 fermentation from a 7.5-L fermentor to a pilot scale 100-L fermentor. Initial preparation and fermentations were conducted in strictly anaerobic conditions. The fermentation system was maintained in a batch mode with continuous syngas supply. The effect of anaerobic fermentation in a pilot scale fermentor was evaluated. In addition, the impact of improving the syngas mass transfer coefficient on the utilization and product formation was studied. Results indicate a six fold improvement in ethanol concentration compared to serum bottle fermentation, and formation of other compounds such as isopropyl alcohol, acetic acid and butanol, which are of commercial importance.</description><subject>Anaerobic</subject><subject>ANAEROBIOSE</subject><subject>ANAEROBIOSIS</subject><subject>BIOCATALIZADOR</subject><subject>BIOCATALYSEUR</subject><subject>BIOCATALYSTS</subject><subject>Biological and medical sciences</subject><subject>BIOMASA</subject><subject>BIOMASS</subject><subject>BIOMASSE</subject><subject>Bioreactors</subject><subject>Bioreactors - microbiology</subject><subject>Biotechnology</subject><subject>CLOSTRIDIO</subject><subject>CLOSTRIDIUM</subject><subject>Clostridium - metabolism</subject><subject>Computer Simulation</subject><subject>Computer-Aided Design</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>ETANOL</subject><subject>ETHANOL</subject><subject>Ethanol - metabolism</subject><subject>FERMENTACION</subject><subject>FERMENTADORES</subject><subject>FERMENTATION</subject><subject>Fermentation - physiology</subject><subject>FERMENTERS</subject><subject>FERMENTEUR</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>http://www.fao.org/aos/agrovoc#c_10677</subject><subject>http://www.fao.org/aos/agrovoc#c_1680</subject><subject>http://www.fao.org/aos/agrovoc#c_23990</subject><subject>http://www.fao.org/aos/agrovoc#c_27460</subject><subject>http://www.fao.org/aos/agrovoc#c_27522</subject><subject>http://www.fao.org/aos/agrovoc#c_2855</subject><subject>http://www.fao.org/aos/agrovoc#c_926</subject><subject>Methods. Procedures. Technologies</subject><subject>Microbial engineering. Fermentation and microbial culture technology</subject><subject>Models, Biological</subject><subject>Starch - metabolism</subject><subject>Syngas</subject><subject>Various methods and equipments</subject><issn>1389-1723</issn><issn>1347-4421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAQgCMEog_4B4B8qXrKMn4kdjggVeVR0EogAeJoOfZk5VXWXuwsUv99HbKFGz3Zmvnmofmq6gWFFQXavt6utr2P2a4YQFdCK2DsUXVKuZC1EIw-nv-qq6lk_KQ6y3kLQCVI-rQ6YVAoKflp9fPbbdiYTAZMOwyTmXwMxAdiCAWo12TvxziRbM2I90xMb8g7zH5TqODIPkWLORMbQ_YO058W-Vn1ZDBjxufH97z68eH99-ubev3l46frq3Vtm7ab6s5YS13DWmFlY9SgaE9t56hyzFHkKEDwEoEBmeG06yTrO057cKJlRjUDP68ul75ljV8HzJPe-WxxHE3AeMhatV2jyoXYg6QULW2BSfEwybkoq8BMioW0KeaccND75Hcm3WoKerakt3qxpGdLc7RYKmWvjgMO_Q7d36J7LQW4OAJmPv2QTLA-_-OYEqxpVOFeLtxgojabVJjPXxkUdcA5yJJ_u-SxKPjtMelsPQaLzie0k3bR_3_TO0mUuQc</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Kundiyana, Dimple K.</creator><creator>Huhnke, Raymond L.</creator><creator>Wilkins, Mark R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100501</creationdate><title>Syngas fermentation in a 100-L pilot scale fermentor: Design and process considerations</title><author>Kundiyana, Dimple K. ; Huhnke, Raymond L. ; Wilkins, Mark R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-9acc1d5264c75a8f81b1c9d18d2d1e3e4043b1c0fe2a319972b931b0d462a85f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Anaerobic</topic><topic>ANAEROBIOSE</topic><topic>ANAEROBIOSIS</topic><topic>BIOCATALIZADOR</topic><topic>BIOCATALYSEUR</topic><topic>BIOCATALYSTS</topic><topic>Biological and medical sciences</topic><topic>BIOMASA</topic><topic>BIOMASS</topic><topic>BIOMASSE</topic><topic>Bioreactors</topic><topic>Bioreactors - microbiology</topic><topic>Biotechnology</topic><topic>CLOSTRIDIO</topic><topic>CLOSTRIDIUM</topic><topic>Clostridium - metabolism</topic><topic>Computer Simulation</topic><topic>Computer-Aided Design</topic><topic>Equipment Design</topic><topic>Equipment Failure Analysis</topic><topic>ETANOL</topic><topic>ETHANOL</topic><topic>Ethanol - metabolism</topic><topic>FERMENTACION</topic><topic>FERMENTADORES</topic><topic>FERMENTATION</topic><topic>Fermentation - physiology</topic><topic>FERMENTERS</topic><topic>FERMENTEUR</topic><topic>Fundamental and applied biological sciences. 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Fermentation and microbial culture technology</topic><topic>Models, Biological</topic><topic>Starch - metabolism</topic><topic>Syngas</topic><topic>Various methods and equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kundiyana, Dimple K.</creatorcontrib><creatorcontrib>Huhnke, Raymond L.</creatorcontrib><creatorcontrib>Wilkins, Mark R.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of bioscience and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kundiyana, Dimple K.</au><au>Huhnke, Raymond L.</au><au>Wilkins, Mark R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Syngas fermentation in a 100-L pilot scale fermentor: Design and process considerations</atitle><jtitle>Journal of bioscience and bioengineering</jtitle><addtitle>J Biosci Bioeng</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>109</volume><issue>5</issue><spage>492</spage><epage>498</epage><pages>492-498</pages><issn>1389-1723</issn><eissn>1347-4421</eissn><abstract>Fermentation of syngas offers several advantages compared to chemical catalysts such as higher specificity of biocatalysts, lower energy costs, and higher carbon efficiency. Scale-up of syngas fermentation from a bench scale to a pilot scale fermentor is a critical step leading to commercialization. The primary objective of this research was to install and commission a pilot scale fermentor, and subsequently scale-up the
Clostridium strain P11 fermentation from a 7.5-L fermentor to a pilot scale 100-L fermentor. Initial preparation and fermentations were conducted in strictly anaerobic conditions. The fermentation system was maintained in a batch mode with continuous syngas supply. The effect of anaerobic fermentation in a pilot scale fermentor was evaluated. In addition, the impact of improving the syngas mass transfer coefficient on the utilization and product formation was studied. Results indicate a six fold improvement in ethanol concentration compared to serum bottle fermentation, and formation of other compounds such as isopropyl alcohol, acetic acid and butanol, which are of commercial importance.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20347773</pmid><doi>10.1016/j.jbiosc.2009.10.022</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of bioscience and bioengineering, 2010-05, Vol.109 (5), p.492-498 |
| issn | 1389-1723 1347-4421 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anaerobic ANAEROBIOSE ANAEROBIOSIS BIOCATALIZADOR BIOCATALYSEUR BIOCATALYSTS Biological and medical sciences BIOMASA BIOMASS BIOMASSE Bioreactors Bioreactors - microbiology Biotechnology CLOSTRIDIO CLOSTRIDIUM Clostridium - metabolism Computer Simulation Computer-Aided Design Equipment Design Equipment Failure Analysis ETANOL ETHANOL Ethanol - metabolism FERMENTACION FERMENTADORES FERMENTATION Fermentation - physiology FERMENTERS FERMENTEUR Fundamental and applied biological sciences. Psychology http://www.fao.org/aos/agrovoc#c_10677 http://www.fao.org/aos/agrovoc#c_1680 http://www.fao.org/aos/agrovoc#c_23990 http://www.fao.org/aos/agrovoc#c_27460 http://www.fao.org/aos/agrovoc#c_27522 http://www.fao.org/aos/agrovoc#c_2855 http://www.fao.org/aos/agrovoc#c_926 Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology Models, Biological Starch - metabolism Syngas Various methods and equipments |
| title | Syngas fermentation in a 100-L pilot scale fermentor: Design and process considerations |
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