Innate immunity in DNA vaccine with Toxoplasma gondii -heat shock protein 70 gene that induces DC activation and Th1 polarization

Abstract Toxoplasma gondii -derived heat shock protein 70 ( T.g. HSP70) is a tachyzoite-specific virulent molecule expressed before the death of hosts. We have already demonstrated the vaccine effects of T.g. HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) to limit T. gondii...

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Veröffentlicht in:	Vaccine 2011-02, Vol.29 (10), p.1899-1905
Hauptverfasser:	Makino, Masayuki, Uemura, Noriko, Moroda, Masataka, Kikumura, Akitoshi, Piao, Lian-Xun, Mohamed, Rabie M, Aosai, Fumie
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Applied microbiology Biological and medical sciences Brain CD4-Positive T-Lymphocytes - immunology Cell activation Cysts DC vaccine death Dendritic cells Dendritic Cells - immunology DNA vaccines Female Fundamental and applied biological sciences. Psychology gamma -Interferon Gene Expression Profiling Gene targeting Genes heat-shock protein 70 Helper cells hosts HSP70 HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - immunology Hsp70 protein Immune system Immunity Infections innate immunity interferon-gamma Interferon-gamma - biosynthesis Interleukin 12 Interleukin 17 Interleukin 4 Interleukin-17 - biosynthesis Interleukin-4 - biosynthesis Lymph nodes Lymph Nodes - immunology Lymphocytes T messenger RNA Mice Mice, Inbred C57BL Microbiology mRNA MyD88 protein Parasites Plasmids Plasmids - administration & dosage Polarization Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Vaccines - genetics Protozoan Vaccines - immunology recombinant vaccines RNA, Messenger - biosynthesis RNA, Messenger - genetics Signal transduction Skin T.g.HSP70 gene vaccine Th1 Cells - immunology Th1 polarization TLR4 protein Toll-like receptors Toxoplasma Toxoplasma - genetics Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis Transcription activation vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - genetics Vaccines, DNA - immunology virulence
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