OPTIMIZING INTERPRETATION OF THE TUBERCULIN TEST USING AN INTERFERON-GAMMA RELEASE ASSAY AS A REFERENCE STANDARD
The interferon-gamma release assays have greater specificity than the tuberculin skin test (TST), and at least equal sensitivity. We analyzed the sensitivity and specificity of the TST in immunocompetent children considering QuantiFERON as the referent standard. A TST cut-off point of ≥5 mm indicate...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2011-05, Vol.30 (5), p.426-428 |
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| container_end_page | 428 |
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| container_issue | 5 |
| container_start_page | 426 |
| container_title | The Pediatric infectious disease journal |
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| creator | Méndez-Echevarría, Ana González-Muñoz, Miguel Mellado, Maria Jose Baquero-Artigao, Fernando Vecino, Raquel Pérez, Elia |
| description | The interferon-gamma release assays have greater specificity than the tuberculin skin test (TST), and at least equal sensitivity. We analyzed the sensitivity and specificity of the TST in immunocompetent children considering QuantiFERON as the referent standard. A TST cut-off point of ≥5 mm indicates excellent sensitivity (100%) and specificity (93%) in children without Bacillus Calmette-Guérin. In Bacillus Calmette-Guérin-vaccinated children, the TST cut-off point of ≥10 mm had poorer specificity (86%), and a cut-off point of ≥15 mm resulted in reduced sensitivity (60%). |
| doi_str_mv | 10.1097/INF.0b013e3182001294 |
| format | Article |
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| identifier | ISSN: 0891-3668 |
| ispartof | The Pediatric infectious disease journal, 2011-05, Vol.30 (5), p.426-428 |
| issn | 0891-3668 1532-0987 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Bacterial diseases BCG Vaccine - immunology Biological and medical sciences Child Child, Preschool Clinical Laboratory Techniques - methods Female General aspects Human bacterial diseases Humans Immunoassay - methods Infant Infectious diseases Interferon-gamma - secretion Male Medical sciences Reference Standards Sensitivity and Specificity Tuberculin Test - methods Tuberculosis - diagnosis Tuberculosis - immunology Tuberculosis and atypical mycobacterial infections |
| title | OPTIMIZING INTERPRETATION OF THE TUBERCULIN TEST USING AN INTERFERON-GAMMA RELEASE ASSAY AS A REFERENCE STANDARD |
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