Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects

Dysfunction of the dopamine neurotransmitter system has long been implicated in depression. Now, Fang Liu and colleagues show that the interaction between two dopamine receptor subtypes is increased in the brain of subjects with major depression. Blocking this interaction in rodent models of depress...

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Veröffentlicht in:	Nature medicine 2010-12, Vol.16 (12), p.1393-1395
Hauptverfasser:	Pei, Lin, Li, Shupeng, Wang, Min, Diwan, Mustansir, Anisman, Hymie, Fletcher, Paul J, Nobrega, José N, Liu, Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/304 631/92/612/194 692/699/476/1414 692/700/565 Analysis of Variance Animals Antidepressants Biochemistry Biomedical and Life Sciences Biomedical research Biomedicine Blotting, Western Brain brief-communication Cancer Research Care and treatment Cell Line Depression - drug therapy Depression - metabolism Depression - physiopathology Depression, Mental Dimerization Dopamine Dopamine receptors Escape Reaction - drug effects Genetic aspects Health aspects Helplessness, Learned Humans Immunoprecipitation Infectious Diseases Locomotion - drug effects Locomotor activity Mental depression Metabolic Diseases Molecular Medicine Multiprotein Complexes - metabolism Neurosciences Organic Anion Transporters - metabolism Physiological aspects Prefrontal Cortex - metabolism Protein Binding - drug effects Rats Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Recombinant Fusion Proteins - therapeutic use tat Gene Products, Human Immunodeficiency Virus - genetics
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