Neem Leaf Extract Induces Radiosensitization in Human Neuroblastoma Xenograft Through Modulation of Apoptotic Pathway

Induction of apoptosis is directly correlated with the biological effectiveness of ionizing radiation (IR). Accordingly, we investigated the efficacy of neem leaf extract (NLE) on IR-associated apoptotic transcriptional modulation and cell death in neuroblastoma (NB). NB xenografts exposed to single...

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Veröffentlicht in:	Anticancer research 2011, Vol.31 (1), p.161-170
Hauptverfasser:	VEERARAGHAVAN, Jamunarani, ARAVINDAN, Sheeja, NATARAJAN, Mohan, AWASTHI, Vibhudutta, HERMAN, Terence S, ARAVINDAN, Natarajan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - radiation effects Azadirachta - chemistry Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain Neoplasms - drug therapy Brain Neoplasms - pathology Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - radiation effects Humans Medical sciences Mice Mice, Nude Neuroblastoma - drug therapy Neuroblastoma - pathology Neurology Plant Extracts - pharmacology Plant Leaves - chemistry Radiation, Ionizing Radiation-Sensitizing Agents - therapeutic use Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Signal Transduction - drug effects Signal Transduction - radiation effects Tumor Cells, Cultured Tumors Tumors of the nervous system. Phacomatoses Xenograft Model Antitumor Assays
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