Evaluating the effects of estradiol on endothelial nitric oxide stimulated by erythrocyte-derived ATP using a microfluidic approach

Recently, estrogens have been reported to have protective effects against experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). Although the molecular mechanism for such a protective effect is currently incomplete, we hypothesized that estradiol may reduce the r...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2010-08, Vol.397 (8), p.3369-3375
Hauptverfasser:	Letourneau, Suzanne, Hernandez, Luiza, Faris, Andrea N, Spence, Dana M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Adenosine Triphosphate - metabolism Analysis Analytical Chemistry Animals ATP Attenuation Bioanalytical methods Biochemistry Biological samples Biotechnological products Cattle Cell systems/single-cell analysis Cells, Cultured Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Devices Endothelial cells Endothelial Cells - chemistry Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium-derived relaxing factors Erythrocytes Erythrocytes - chemistry Erythrocytes - metabolism Estradiol Estradiol - pharmacology Estrogens Estrogens - pharmacology Evaluation Fluorescence microscopy Fluorescence/luminescence Food Science Laboratory animals Laboratory Medicine Male Methods Microfluidic Analytical Techniques - instrumentation Microfluidic Analytical Techniques - methods Microfluidics Microfluidics/microfabrication Monitoring/Environmental Analysis Multiple sclerosis Nitric oxide Nitric Oxide - metabolism Original Paper Physiological aspects Protective Rabbits
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