Preclinical evaluation of the saponin derivative GPI-0100 as an immunostimulating and dose-sparing adjuvant for pandemic influenza vaccines

With the current global influenza vaccine production capacity the large demand for vaccines in case of a pandemic can only be fulfilled when antigen dose sparing strategies are employed. Here we used a murine challenge model to evaluate the potential of GPI-0100, a semi-synthetic saponin derivative,...

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Veröffentlicht in:	Vaccine 2011-03, Vol.29 (11), p.2037-2043
Hauptverfasser:	Liu, Heng, Bungener, Laura, ter Veer, Wouter, Coller, Beth-Ann, Wilschut, Jan, Huckriede, Anke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - pharmacology Allergy and Immunology Aluminum Animals Antibodies, Viral - blood antigens Applied microbiology Aqueous solutions Biological and medical sciences cell-mediated immunity Cytokines Dose-Response Relationship, Immunologic Dose-sparing Drug Evaluation, Preclinical Female Fundamental and applied biological sciences. Psychology Genotype & phenotype GPI-0100 Hemagglutinin Glycoproteins, Influenza Virus - immunology hemagglutinins Immunity, Cellular Immunity, Humoral Immunization Immunoglobulin G - blood Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Lung - virology lungs Medical research Mice Mice, Inbred BALB C Microbiology Mortality Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control pandemic Pandemics phenotype Production capacity Saponins - immunology Studies Swine flu Toxicity Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Subunit - immunology viral load Viruses
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