Differential activation of host cell signalling pathways through infection with two variants of influenza A/Puerto Rico/8/34 (H1N1) in MDCK cells

Abstract In cell culture-based influenza vaccine production, few efforts have been undertaken to characterise virus–host cell interactions in detail. Two influenza virus strains that grew to different virus titres, and differed in virus dynamics, apoptosis induction and proteome changes were observe...

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Veröffentlicht in:	Vaccine 2010-11, Vol.28 (51), p.8210-8218
Hauptverfasser:	Heynisch, B, Frensing, T, Heinze, K, Seitz, C, Genzel, Y, Reichl, U
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Apoptosis Applied microbiology Biological and medical sciences Cell Line Dogs Fundamental and applied biological sciences. Psychology Host-Pathogen Interactions Immune response Immune system Influenza A virus Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - growth & development Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - pathogenicity Influenza vaccine production Interferon signalling Kinases Manufacturing industry MDCK Microbiology Milk Phosphorylation Proteins Proteome - analysis Signal Transduction Studies Transcription factors Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral Load Viruses Virus–host cell interaction
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