Influence of P-glycoprotein inhibition on secretion of ivermectin and doramectin by milk in lactating sheep

The aim of to the present study was to evaluate the effects of verapamil (VER) on plasma pharmacokinetics of ivermectin (IVM) and doramectin (DOR) in lactating Istrian Pramenka dairy sheep and to investigate the role of P-glycoprotein (P-gp) in transport of avermectins into milk. Pharmacokinetics of...

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Veröffentlicht in:	Veterinary parasitology 2011-06, Vol.179 (1), p.159-166
Hauptverfasser:	Antonić, Jan, Grabnar, Iztok, Milčinski, Luka, Škibin, Andrej, Süssinger, Adica, Pogačnik, Milan, Cerkvenik-Flajs, Vesna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintics - chemistry Anthelmintics - metabolism Area Under Curve ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors Doramectin Half-Life Ivermectin Ivermectin - analogs & derivatives Ivermectin - chemistry Ivermectin - pharmacokinetics Milk Milk - chemistry P-glycoprotein Plasma Sheep Sheep - blood Sheep - metabolism Verapamil Verapamil - pharmacology
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