PASS assisted prediction and pharmacological evaluation of novel nicotinic analogs for nootropic activity in mice

The aim of present study is to predict the probable nootropic activity of novel nicotine analogues with the help of computer program, PASS (prediction of activity spectra for substances) and evaluate the same. Two compounds from differently substituted pyridines were selected for synthesis and evalu...

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Veröffentlicht in:	European journal of pharmacology 2011-07, Vol.662 (1-3), p.22-30
Hauptverfasser:	Khurana, Navneet, Ishar, Mohan Pal Singh, Gajbhiye, Asmita, Goel, Rajesh Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine esterase activity Acetylcholinesterase - metabolism Animals Biological and medical sciences Cognition - drug effects Computational Biology - methods Drug Evaluation, Preclinical Female Locomotion - drug effects Medical sciences Memory - drug effects Mice Muscles - drug effects Muscles - physiology Nicotine - administration & dosage Nicotine - adverse effects Nicotine - analogs & derivatives Nicotine - pharmacology Nicotine acetylcholine receptor Nicotine analog Nootropic agent Nootropic Agents - administration & dosage Nootropic Agents - adverse effects Nootropic Agents - chemistry Nootropic Agents - pharmacology Pharmacology. Drug treatments Reaction Time - drug effects Receptors, Nicotinic - metabolism Scopolamine Hydrobromide - pharmacology
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