Acute Renal Failure and Renal Replacement Therapy in the Postoperative Period of Orthotopic Liver Transplant Patients Versus Nonelective Abdominal Surgery Patients
Abstract Acute renal failure (ARF) often complicates the postoperative period of patients undergoing orthotopic liver transplantation (OLT); it is habitually associated with high mortality rates. Similarly, patients undergoing major nonelective abdominal surgery are prone to ARF because of their fre...
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| Veröffentlicht in: | Transplantation proceedings 2011-05, Vol.43 (4), p.1145-1147 |
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| creator | Biagioni, E Cavazzuti, I Busani, S Trevisan, D Zavatti, L Ferrari, E Massimo, G |
| description | Abstract Acute renal failure (ARF) often complicates the postoperative period of patients undergoing orthotopic liver transplantation (OLT); it is habitually associated with high mortality rates. Similarly, patients undergoing major nonelective abdominal surgery are prone to ARF because of their frequent preexistent morbidities, abdominal sepsis, and needed for extended surgical procedures. The aim of this study was to evaluate the incidence of ARF and use of renal replacement therapy (RRT) among OLT versus nonelective abdominal surgery patients and associations with clinical outcomes. We studied all the patients admitted to a surgical intensive care unit (ICU) from January 2008 to December 2009 after OLT or nonelective abdominal surgery. The inclusion criteria were an ICU stay of at least 48 hours and without prior end-stage renal failure. OLT patients ( n = 84) were younger and less severly ill than surgery patients ( n = 60). ARF occurrence was lower among the OLT (29%) than the surgery group (47%) requiring RRT in 71% and 53% of patients due to ARF, respectively. The ICU mortality of ARF patients in both groups (29% OLT and 51% surgery) were greater than among subjects without ARF (2% and 6%). The occurrence of ARF is common among these two patient groups, and associated with increased risk of death among in surgery (+45%) versus in OLT (+27%) patients. |
| doi_str_mv | 10.1016/j.transproceed.2011.02.051 |
| format | Article |
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Similarly, patients undergoing major nonelective abdominal surgery are prone to ARF because of their frequent preexistent morbidities, abdominal sepsis, and needed for extended surgical procedures. The aim of this study was to evaluate the incidence of ARF and use of renal replacement therapy (RRT) among OLT versus nonelective abdominal surgery patients and associations with clinical outcomes. We studied all the patients admitted to a surgical intensive care unit (ICU) from January 2008 to December 2009 after OLT or nonelective abdominal surgery. The inclusion criteria were an ICU stay of at least 48 hours and without prior end-stage renal failure. OLT patients ( n = 84) were younger and less severly ill than surgery patients ( n = 60). ARF occurrence was lower among the OLT (29%) than the surgery group (47%) requiring RRT in 71% and 53% of patients due to ARF, respectively. The ICU mortality of ARF patients in both groups (29% OLT and 51% surgery) were greater than among subjects without ARF (2% and 6%). The occurrence of ARF is common among these two patient groups, and associated with increased risk of death among in surgery (+45%) versus in OLT (+27%) patients.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2011.02.051</identifier><identifier>PMID: 21620074</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Abdomen - surgery ; Acute Kidney Injury - etiology ; Acute Kidney Injury - mortality ; Acute Kidney Injury - therapy ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Chi-Square Distribution ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Incidence ; Intensive Care Units ; Italy ; Length of Stay ; Liver Transplantation - adverse effects ; Liver Transplantation - mortality ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Renal failure ; Renal Replacement Therapy ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical Procedures, Operative - adverse effects ; Surgical Procedures, Operative - mortality ; Time Factors ; Tissue, organ and graft immunology ; Treatment Outcome</subject><ispartof>Transplantation proceedings, 2011-05, Vol.43 (4), p.1145-1147</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. 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Similarly, patients undergoing major nonelective abdominal surgery are prone to ARF because of their frequent preexistent morbidities, abdominal sepsis, and needed for extended surgical procedures. The aim of this study was to evaluate the incidence of ARF and use of renal replacement therapy (RRT) among OLT versus nonelective abdominal surgery patients and associations with clinical outcomes. We studied all the patients admitted to a surgical intensive care unit (ICU) from January 2008 to December 2009 after OLT or nonelective abdominal surgery. The inclusion criteria were an ICU stay of at least 48 hours and without prior end-stage renal failure. OLT patients ( n = 84) were younger and less severly ill than surgery patients ( n = 60). ARF occurrence was lower among the OLT (29%) than the surgery group (47%) requiring RRT in 71% and 53% of patients due to ARF, respectively. The ICU mortality of ARF patients in both groups (29% OLT and 51% surgery) were greater than among subjects without ARF (2% and 6%). The occurrence of ARF is common among these two patient groups, and associated with increased risk of death among in surgery (+45%) versus in OLT (+27%) patients.</description><subject>Abdomen - surgery</subject><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - mortality</subject><subject>Acute Kidney Injury - therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intensive Care Units</subject><subject>Italy</subject><subject>Length of Stay</subject><subject>Liver Transplantation - adverse effects</subject><subject>Liver Transplantation - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Renal failure</subject><subject>Renal Replacement Therapy</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical Procedures, Operative - adverse effects</subject><subject>Surgical Procedures, Operative - mortality</subject><subject>Time Factors</subject><subject>Tissue, organ and graft immunology</subject><subject>Treatment Outcome</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9uEzEQxlcIREPhFZCFhDgljP9ulgNSVCggVbRqA1fL8c4Sh8062LuV8jy8KLNNCogTJ2s8v_lmNN8UxQsOMw7cvN7M-uS6vEvRI9YzAZzPQMxA8wfFhM9LORVGyIfFBEDxKZdKnxRPct4AxULJx8WJ4EYAlGpS_Fz4oUd2jZ1r2bkL7ZCQua4-_lzjrnUet9j1bLnG5HZ7FjrWr5FdxdzHHX314ZYiTCHWLDbsMvXrSJng2QVlElveDds6krgimKQy-4opD5l9jh226O8UFqs6bsPY9GZI3zDtf9NPi0eNazM-O76nxZfz98uzj9OLyw-fzhYXU6-M6qe1Ag6VaMCstGpk4yuvjeJlKSso543g3jhVVXNvtEQHqEq90sJUms8r3RiQp8Wrgy5t9seAubfbkD22NDrGIdu5qRRIJUbyzYH0KeacsLG7FLYu7S0HO3pkN_Zvj-zokQVhySMqfn5sM6y2lLsvvTeFgJdHwGXv2oaEfMh_OCVIzhji3h04pKXcBkw2e1qYxzokWqqtY_i_ed7-I-Pb0AXq_B33mDdxSORKttxmKrA341WNR8U5gNSllr8AgdLNbg</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Biagioni, E</creator><creator>Cavazzuti, I</creator><creator>Busani, S</creator><creator>Trevisan, D</creator><creator>Zavatti, L</creator><creator>Ferrari, E</creator><creator>Massimo, G</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Acute Renal Failure and Renal Replacement Therapy in the Postoperative Period of Orthotopic Liver Transplant Patients Versus Nonelective Abdominal Surgery Patients</title><author>Biagioni, E ; Cavazzuti, I ; Busani, S ; Trevisan, D ; Zavatti, L ; Ferrari, E ; Massimo, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-d401092f06b54f3fc9c56417739078f21c6a4998c653ea0e475b526951895f603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdomen - surgery</topic><topic>Acute Kidney Injury - etiology</topic><topic>Acute Kidney Injury - mortality</topic><topic>Acute Kidney Injury - therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intensive Care Units</topic><topic>Italy</topic><topic>Length of Stay</topic><topic>Liver Transplantation - adverse effects</topic><topic>Liver Transplantation - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Renal failure</topic><topic>Renal Replacement Therapy</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgical Procedures, Operative - adverse effects</topic><topic>Surgical Procedures, Operative - mortality</topic><topic>Time Factors</topic><topic>Tissue, organ and graft immunology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biagioni, E</creatorcontrib><creatorcontrib>Cavazzuti, I</creatorcontrib><creatorcontrib>Busani, S</creatorcontrib><creatorcontrib>Trevisan, D</creatorcontrib><creatorcontrib>Zavatti, L</creatorcontrib><creatorcontrib>Ferrari, E</creatorcontrib><creatorcontrib>Massimo, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biagioni, E</au><au>Cavazzuti, I</au><au>Busani, S</au><au>Trevisan, D</au><au>Zavatti, L</au><au>Ferrari, E</au><au>Massimo, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Renal Failure and Renal Replacement Therapy in the Postoperative Period of Orthotopic Liver Transplant Patients Versus Nonelective Abdominal Surgery Patients</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>43</volume><issue>4</issue><spage>1145</spage><epage>1147</epage><pages>1145-1147</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Acute renal failure (ARF) often complicates the postoperative period of patients undergoing orthotopic liver transplantation (OLT); it is habitually associated with high mortality rates. Similarly, patients undergoing major nonelective abdominal surgery are prone to ARF because of their frequent preexistent morbidities, abdominal sepsis, and needed for extended surgical procedures. The aim of this study was to evaluate the incidence of ARF and use of renal replacement therapy (RRT) among OLT versus nonelective abdominal surgery patients and associations with clinical outcomes. We studied all the patients admitted to a surgical intensive care unit (ICU) from January 2008 to December 2009 after OLT or nonelective abdominal surgery. The inclusion criteria were an ICU stay of at least 48 hours and without prior end-stage renal failure. OLT patients ( n = 84) were younger and less severly ill than surgery patients ( n = 60). ARF occurrence was lower among the OLT (29%) than the surgery group (47%) requiring RRT in 71% and 53% of patients due to ARF, respectively. The ICU mortality of ARF patients in both groups (29% OLT and 51% surgery) were greater than among subjects without ARF (2% and 6%). The occurrence of ARF is common among these two patient groups, and associated with increased risk of death among in surgery (+45%) versus in OLT (+27%) patients.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>21620074</pmid><doi>10.1016/j.transproceed.2011.02.051</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen - surgery Acute Kidney Injury - etiology Acute Kidney Injury - mortality Acute Kidney Injury - therapy Adult Aged Aged, 80 and over Biological and medical sciences Chi-Square Distribution Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Incidence Intensive Care Units Italy Length of Stay Liver Transplantation - adverse effects Liver Transplantation - mortality Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Renal failure Renal Replacement Therapy Retrospective Studies Risk Assessment Risk Factors Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Procedures, Operative - adverse effects Surgical Procedures, Operative - mortality Time Factors Tissue, organ and graft immunology Treatment Outcome |
| title | Acute Renal Failure and Renal Replacement Therapy in the Postoperative Period of Orthotopic Liver Transplant Patients Versus Nonelective Abdominal Surgery Patients |
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