N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study
The purpose of the present prospective randomized study was to evaluate the effects of n-3 polyunsaturated fatty acids on recurrence rates of atrial fibrillation (AF) and inflammation after electrical cardioversion. Calculation of the number of patients needed was based on the assumption of 20% and...
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| Veröffentlicht in: | Anadolu kardiyoloji dergisi : AKD 2011-06, Vol.11 (4), p.305-309 |
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| creator | Ozaydın, Mehmet Erdoğan, Doğan Tayyar, Senol Uysal, Bayram Ali Doğan, Abdullah Içli, Atilla Ozkan, Emel Varol, Ercan Türker, Yasin Arslan, Akif |
| description | The purpose of the present prospective randomized study was to evaluate the effects of n-3 polyunsaturated fatty acids on recurrence rates of atrial fibrillation (AF) and inflammation after electrical cardioversion.
Calculation of the number of patients needed was based on the assumption of 20% and 65% chance of maintaining sinus rhythm with amiodarone and with polyunsaturated fatty acids, respectively. To observe a significant difference with an alpha level of 0.05 and a power of 0.80 it was necessary to include 22 patients in each group. A total of 47 patients were randomized to amiodarone (n=24) and amiodarone plus n-3 polyunsaturated fatty acids (n=23) groups before scheduled electrical cardioversion. The end-point was the recurrence of AF during 12-month follow-up. Effect of n-3 polyunsaturated fatty acids on inflammation was evaluated with high sensitivity C-reactive protein level measurements. Statistical analysis was performed using unpaired Student' t, Mann Whitney U and Chi-square tests. We analyzed the recurrence of AF using the Cox proportional hazards regression model to control for potentially confounding factors.
Nine patients in the amiodarone group (37.5%), and 9 patients in the amiodarone plus n-3 polyunsaturated fatty acids group (39.1%) had recurrence of AF during follow-up (p=1). With the Cox proportional model, risk factors for the recurrence of AF were previous electrical cardioversion (HR 10.33, 95% CI 1.74 to 61.10, p=0.01) and high sensitivity C-reactive protein levels (HR 1.07, 95% CI 1.02 to 1.38, p=0.007). High sensitivity C-reactive protein levels at baseline, at day 15 and during AF recurrence were similar between two groups (p > 0.05 for all).
N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation. |
| doi_str_mv | 10.5152/akd.2011.080 |
| format | Article |
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Calculation of the number of patients needed was based on the assumption of 20% and 65% chance of maintaining sinus rhythm with amiodarone and with polyunsaturated fatty acids, respectively. To observe a significant difference with an alpha level of 0.05 and a power of 0.80 it was necessary to include 22 patients in each group. A total of 47 patients were randomized to amiodarone (n=24) and amiodarone plus n-3 polyunsaturated fatty acids (n=23) groups before scheduled electrical cardioversion. The end-point was the recurrence of AF during 12-month follow-up. Effect of n-3 polyunsaturated fatty acids on inflammation was evaluated with high sensitivity C-reactive protein level measurements. Statistical analysis was performed using unpaired Student' t, Mann Whitney U and Chi-square tests. We analyzed the recurrence of AF using the Cox proportional hazards regression model to control for potentially confounding factors.
Nine patients in the amiodarone group (37.5%), and 9 patients in the amiodarone plus n-3 polyunsaturated fatty acids group (39.1%) had recurrence of AF during follow-up (p=1). With the Cox proportional model, risk factors for the recurrence of AF were previous electrical cardioversion (HR 10.33, 95% CI 1.74 to 61.10, p=0.01) and high sensitivity C-reactive protein levels (HR 1.07, 95% CI 1.02 to 1.38, p=0.007). High sensitivity C-reactive protein levels at baseline, at day 15 and during AF recurrence were similar between two groups (p > 0.05 for all).
N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation.</description><identifier>ISSN: 1302-8723</identifier><identifier>EISSN: 1308-0032</identifier><identifier>DOI: 10.5152/akd.2011.080</identifier><identifier>PMID: 21543294</identifier><language>eng</language><publisher>Turkey</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Amiodarone - administration & dosage ; Anti-Arrhythmia Agents - administration & dosage ; Atrial Fibrillation - blood ; Atrial Fibrillation - etiology ; Atrial Fibrillation - prevention & control ; C-Reactive Protein - analysis ; Drug Administration Schedule ; Electric Countershock ; Fatty Acids, Omega-3 - administration & dosage ; Female ; Humans ; Inflammation - blood ; Inflammation - etiology ; Inflammation - prevention & control ; Male ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; Secondary Prevention ; Treatment Outcome</subject><ispartof>Anadolu kardiyoloji dergisi : AKD, 2011-06, Vol.11 (4), p.305-309</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-3eb01c8e95b91023a8c6f2102b81f426b5d992ced1c4473e4cecddf7c904da413</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21543294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozaydın, Mehmet</creatorcontrib><creatorcontrib>Erdoğan, Doğan</creatorcontrib><creatorcontrib>Tayyar, Senol</creatorcontrib><creatorcontrib>Uysal, Bayram Ali</creatorcontrib><creatorcontrib>Doğan, Abdullah</creatorcontrib><creatorcontrib>Içli, Atilla</creatorcontrib><creatorcontrib>Ozkan, Emel</creatorcontrib><creatorcontrib>Varol, Ercan</creatorcontrib><creatorcontrib>Türker, Yasin</creatorcontrib><creatorcontrib>Arslan, Akif</creatorcontrib><title>N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study</title><title>Anadolu kardiyoloji dergisi : AKD</title><addtitle>Anadolu Kardiyol Derg</addtitle><description>The purpose of the present prospective randomized study was to evaluate the effects of n-3 polyunsaturated fatty acids on recurrence rates of atrial fibrillation (AF) and inflammation after electrical cardioversion.
Calculation of the number of patients needed was based on the assumption of 20% and 65% chance of maintaining sinus rhythm with amiodarone and with polyunsaturated fatty acids, respectively. To observe a significant difference with an alpha level of 0.05 and a power of 0.80 it was necessary to include 22 patients in each group. A total of 47 patients were randomized to amiodarone (n=24) and amiodarone plus n-3 polyunsaturated fatty acids (n=23) groups before scheduled electrical cardioversion. The end-point was the recurrence of AF during 12-month follow-up. Effect of n-3 polyunsaturated fatty acids on inflammation was evaluated with high sensitivity C-reactive protein level measurements. Statistical analysis was performed using unpaired Student' t, Mann Whitney U and Chi-square tests. We analyzed the recurrence of AF using the Cox proportional hazards regression model to control for potentially confounding factors.
Nine patients in the amiodarone group (37.5%), and 9 patients in the amiodarone plus n-3 polyunsaturated fatty acids group (39.1%) had recurrence of AF during follow-up (p=1). With the Cox proportional model, risk factors for the recurrence of AF were previous electrical cardioversion (HR 10.33, 95% CI 1.74 to 61.10, p=0.01) and high sensitivity C-reactive protein levels (HR 1.07, 95% CI 1.02 to 1.38, p=0.007). High sensitivity C-reactive protein levels at baseline, at day 15 and during AF recurrence were similar between two groups (p > 0.05 for all).
N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amiodarone - administration & dosage</subject><subject>Anti-Arrhythmia Agents - administration & dosage</subject><subject>Atrial Fibrillation - blood</subject><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - prevention & control</subject><subject>C-Reactive Protein - analysis</subject><subject>Drug Administration Schedule</subject><subject>Electric Countershock</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Inflammation - etiology</subject><subject>Inflammation - prevention & control</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Secondary Prevention</subject><subject>Treatment Outcome</subject><issn>1302-8723</issn><issn>1308-0032</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UU1P3DAUtCqqLiy9ca5849Is_som6Q2taKmE6AXOkWM_q6aJvbUdpOWn8et421168vjNvNHYQ8gFZ6ua1-JK_7ErwThfsZZ9IKdcsrZiTIqTf1hUbSPkgpzl_MRY3awb9YksBK-VFJ06Ja_3laTbOO7mkHWZky5gqdOl7Kg23maq7eSDzwUZHwO1ETINsdAEdjZAy29AaOaUIOB1v59pdFSX5PVInR-SH8fDrg6W-uBGPU3HgSuQKIxgUG1QbnSyPj5Dykh_o5puU8xbpP3z3jvYOPkXDJjLbHfn5KPTY4bPx3NJHr_fPGxuq7tfP35uru8qI0VbKgkD46aFrh46zoTUrVk7gWhouVNiPdS264QBy41SjQRlwFjrGtMxZbXickkuD74Y5u8MufSTzwbwVQHinPt23SmGP81Q-fWgNBg7J3D9NvlJp13PWb8vq8ey-n1ZPZaF8i9H43mYwP4Xv7cj3wDLvJXp</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Ozaydın, Mehmet</creator><creator>Erdoğan, Doğan</creator><creator>Tayyar, Senol</creator><creator>Uysal, Bayram Ali</creator><creator>Doğan, Abdullah</creator><creator>Içli, Atilla</creator><creator>Ozkan, Emel</creator><creator>Varol, Ercan</creator><creator>Türker, Yasin</creator><creator>Arslan, Akif</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study</title><author>Ozaydın, Mehmet ; Erdoğan, Doğan ; Tayyar, Senol ; Uysal, Bayram Ali ; Doğan, Abdullah ; Içli, Atilla ; Ozkan, Emel ; Varol, Ercan ; Türker, Yasin ; Arslan, Akif</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-3eb01c8e95b91023a8c6f2102b81f426b5d992ced1c4473e4cecddf7c904da413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amiodarone - administration & dosage</topic><topic>Anti-Arrhythmia Agents - administration & dosage</topic><topic>Atrial Fibrillation - blood</topic><topic>Atrial Fibrillation - etiology</topic><topic>Atrial Fibrillation - prevention & control</topic><topic>C-Reactive Protein - analysis</topic><topic>Drug Administration Schedule</topic><topic>Electric Countershock</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>Inflammation - etiology</topic><topic>Inflammation - prevention & control</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Secondary Prevention</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozaydın, Mehmet</creatorcontrib><creatorcontrib>Erdoğan, Doğan</creatorcontrib><creatorcontrib>Tayyar, Senol</creatorcontrib><creatorcontrib>Uysal, Bayram Ali</creatorcontrib><creatorcontrib>Doğan, Abdullah</creatorcontrib><creatorcontrib>Içli, Atilla</creatorcontrib><creatorcontrib>Ozkan, Emel</creatorcontrib><creatorcontrib>Varol, Ercan</creatorcontrib><creatorcontrib>Türker, Yasin</creatorcontrib><creatorcontrib>Arslan, Akif</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anadolu kardiyoloji dergisi : AKD</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozaydın, Mehmet</au><au>Erdoğan, Doğan</au><au>Tayyar, Senol</au><au>Uysal, Bayram Ali</au><au>Doğan, Abdullah</au><au>Içli, Atilla</au><au>Ozkan, Emel</au><au>Varol, Ercan</au><au>Türker, Yasin</au><au>Arslan, Akif</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study</atitle><jtitle>Anadolu kardiyoloji dergisi : AKD</jtitle><addtitle>Anadolu Kardiyol Derg</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>11</volume><issue>4</issue><spage>305</spage><epage>309</epage><pages>305-309</pages><issn>1302-8723</issn><eissn>1308-0032</eissn><abstract>The purpose of the present prospective randomized study was to evaluate the effects of n-3 polyunsaturated fatty acids on recurrence rates of atrial fibrillation (AF) and inflammation after electrical cardioversion.
Calculation of the number of patients needed was based on the assumption of 20% and 65% chance of maintaining sinus rhythm with amiodarone and with polyunsaturated fatty acids, respectively. To observe a significant difference with an alpha level of 0.05 and a power of 0.80 it was necessary to include 22 patients in each group. A total of 47 patients were randomized to amiodarone (n=24) and amiodarone plus n-3 polyunsaturated fatty acids (n=23) groups before scheduled electrical cardioversion. The end-point was the recurrence of AF during 12-month follow-up. Effect of n-3 polyunsaturated fatty acids on inflammation was evaluated with high sensitivity C-reactive protein level measurements. Statistical analysis was performed using unpaired Student' t, Mann Whitney U and Chi-square tests. We analyzed the recurrence of AF using the Cox proportional hazards regression model to control for potentially confounding factors.
Nine patients in the amiodarone group (37.5%), and 9 patients in the amiodarone plus n-3 polyunsaturated fatty acids group (39.1%) had recurrence of AF during follow-up (p=1). With the Cox proportional model, risk factors for the recurrence of AF were previous electrical cardioversion (HR 10.33, 95% CI 1.74 to 61.10, p=0.01) and high sensitivity C-reactive protein levels (HR 1.07, 95% CI 1.02 to 1.38, p=0.007). High sensitivity C-reactive protein levels at baseline, at day 15 and during AF recurrence were similar between two groups (p > 0.05 for all).
N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation.</abstract><cop>Turkey</cop><pmid>21543294</pmid><doi>10.5152/akd.2011.080</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1302-8723 |
| ispartof | Anadolu kardiyoloji dergisi : AKD, 2011-06, Vol.11 (4), p.305-309 |
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| subjects | Adult Aged Aged, 80 and over Amiodarone - administration & dosage Anti-Arrhythmia Agents - administration & dosage Atrial Fibrillation - blood Atrial Fibrillation - etiology Atrial Fibrillation - prevention & control C-Reactive Protein - analysis Drug Administration Schedule Electric Countershock Fatty Acids, Omega-3 - administration & dosage Female Humans Inflammation - blood Inflammation - etiology Inflammation - prevention & control Male Middle Aged Proportional Hazards Models Prospective Studies Secondary Prevention Treatment Outcome |
| title | N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study |
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