Pretreatment HIF-1α and GLUT-1 Expressions Do Not Correlate with Outcome after Preoperative Chemoradiotherapy in Rectal Cancer
The aim of the present study was to investigate hypoxia-inducible factor 1α (HIF-1α) and glucose transporter-1 (GLUT-1) expressions as predictors of response and survival after chemoradiotherapy in pretreatment biopsy specimens from patients with rectal cancer. The immunohistological expressions of...
Gespeichert in:
| Veröffentlicht in: | Anticancer research 2011-05, Vol.31 (5), p.1559-1565 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1565 |
|---|---|
| container_issue | 5 |
| container_start_page | 1559 |
| container_title | Anticancer research |
| container_volume | 31 |
| creator | MAYLAND HAVELUND, Birgitte BRANDT SØRENSEN, Flemming LINDEBJERG, Jan GARM SPINDLER, Karen-Lise JAKOBSEN, Anders |
| description | The aim of the present study was to investigate hypoxia-inducible factor 1α (HIF-1α) and glucose transporter-1 (GLUT-1) expressions as predictors of response and survival after chemoradiotherapy in pretreatment biopsy specimens from patients with rectal cancer.
The immunohistological expressions of HIF-1α and GLUT-1 were investigated in pretreatment biopsies from 86 patients with rectal cancer receiving long course preoperative chemoradiotherapy. The immunohistological stainings were scored semi-quantitatively (percentage of stained cells and staining intensity), and an immunoreactive score was calculated. The response to the chemoradiotherapy was assessed by the Mandard Tumour Regression Grade system (TRG).
No association was found between HIF-1α or GLUT-1 and clinicopathological variables. HIF-1α and GLUT-1 expression had no predictive impact regarding response to chemoradiotherapy measured by TRG and was not associated with overall survival.
The present study did not suggest any predictive or prognostic value of pretreatment HIF-1α or GLUT-1 expression in patients with rectal cancer treated with preoperative chemoradiotherapy. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_869000105</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>869000105</sourcerecordid><originalsourceid>FETCH-LOGICAL-p240t-5470153c2ae865b334f40fb155fe47eb85ae3ab24ea0298bd688c1f1c0950e93</originalsourceid><addsrcrecordid>eNpF0M1Kw0AUBeAgiq3VV5DZiKvAnUwmmSwl9g-KFanrcJPc0EiSiTMTtSufyRfxmQxYcXXh8HHg3BNvyuOE-7EUcOpNIZDgxwBy4l1Y-wIQRYkS594k4BGPAw5T7_PRkDOErqXOsdV64fPvL4ZdyZab553P2fyjN2RtrTvL7jV70I6l2hhq0BF7r92ebQdX6JYYVo4MG_t0TwZd_UYs3VOrDZa1dvsx6w-s7tgTFQ4blmJXkLn0zipsLF0d78zbLea7dOVvtst1erfx-yAE58swBi5FESCpSOZChFUIVc6lrCiMKVcSSWAehIQQJCovI6UKXvECEgmUiJl3-1vbG_06kHVZW9uCmgY70oPNVJQAAAc5yuujHPKWyqw3dYvmkP29bAQ3R4C2wKYy447a_ruQqwQkFz-KV3aC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>869000105</pqid></control><display><type>article</type><title>Pretreatment HIF-1α and GLUT-1 Expressions Do Not Correlate with Outcome after Preoperative Chemoradiotherapy in Rectal Cancer</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>MAYLAND HAVELUND, Birgitte ; BRANDT SØRENSEN, Flemming ; LINDEBJERG, Jan ; GARM SPINDLER, Karen-Lise ; JAKOBSEN, Anders</creator><creatorcontrib>MAYLAND HAVELUND, Birgitte ; BRANDT SØRENSEN, Flemming ; LINDEBJERG, Jan ; GARM SPINDLER, Karen-Lise ; JAKOBSEN, Anders</creatorcontrib><description>The aim of the present study was to investigate hypoxia-inducible factor 1α (HIF-1α) and glucose transporter-1 (GLUT-1) expressions as predictors of response and survival after chemoradiotherapy in pretreatment biopsy specimens from patients with rectal cancer.
The immunohistological expressions of HIF-1α and GLUT-1 were investigated in pretreatment biopsies from 86 patients with rectal cancer receiving long course preoperative chemoradiotherapy. The immunohistological stainings were scored semi-quantitatively (percentage of stained cells and staining intensity), and an immunoreactive score was calculated. The response to the chemoradiotherapy was assessed by the Mandard Tumour Regression Grade system (TRG).
No association was found between HIF-1α or GLUT-1 and clinicopathological variables. HIF-1α and GLUT-1 expression had no predictive impact regarding response to chemoradiotherapy measured by TRG and was not associated with overall survival.
The present study did not suggest any predictive or prognostic value of pretreatment HIF-1α or GLUT-1 expression in patients with rectal cancer treated with preoperative chemoradiotherapy.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 21617210</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Combined Modality Therapy ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Glucose Transporter Type 1 - metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism ; Immunoenzyme Techniques ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Preoperative Care ; Rectal Neoplasms - metabolism ; Rectal Neoplasms - pathology ; Rectal Neoplasms - therapy ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Rate ; Treatment Outcome ; Tumors</subject><ispartof>Anticancer research, 2011-05, Vol.31 (5), p.1559-1565</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24189051$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21617210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAYLAND HAVELUND, Birgitte</creatorcontrib><creatorcontrib>BRANDT SØRENSEN, Flemming</creatorcontrib><creatorcontrib>LINDEBJERG, Jan</creatorcontrib><creatorcontrib>GARM SPINDLER, Karen-Lise</creatorcontrib><creatorcontrib>JAKOBSEN, Anders</creatorcontrib><title>Pretreatment HIF-1α and GLUT-1 Expressions Do Not Correlate with Outcome after Preoperative Chemoradiotherapy in Rectal Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>The aim of the present study was to investigate hypoxia-inducible factor 1α (HIF-1α) and glucose transporter-1 (GLUT-1) expressions as predictors of response and survival after chemoradiotherapy in pretreatment biopsy specimens from patients with rectal cancer.
The immunohistological expressions of HIF-1α and GLUT-1 were investigated in pretreatment biopsies from 86 patients with rectal cancer receiving long course preoperative chemoradiotherapy. The immunohistological stainings were scored semi-quantitatively (percentage of stained cells and staining intensity), and an immunoreactive score was calculated. The response to the chemoradiotherapy was assessed by the Mandard Tumour Regression Grade system (TRG).
No association was found between HIF-1α or GLUT-1 and clinicopathological variables. HIF-1α and GLUT-1 expression had no predictive impact regarding response to chemoradiotherapy measured by TRG and was not associated with overall survival.
The present study did not suggest any predictive or prognostic value of pretreatment HIF-1α or GLUT-1 expression in patients with rectal cancer treated with preoperative chemoradiotherapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Glucose Transporter Type 1 - metabolism</subject><subject>Humans</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</subject><subject>Immunoenzyme Techniques</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Preoperative Care</subject><subject>Rectal Neoplasms - metabolism</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - therapy</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0M1Kw0AUBeAgiq3VV5DZiKvAnUwmmSwl9g-KFanrcJPc0EiSiTMTtSufyRfxmQxYcXXh8HHg3BNvyuOE-7EUcOpNIZDgxwBy4l1Y-wIQRYkS594k4BGPAw5T7_PRkDOErqXOsdV64fPvL4ZdyZab553P2fyjN2RtrTvL7jV70I6l2hhq0BF7r92ebQdX6JYYVo4MG_t0TwZd_UYs3VOrDZa1dvsx6w-s7tgTFQ4blmJXkLn0zipsLF0d78zbLea7dOVvtst1erfx-yAE58swBi5FESCpSOZChFUIVc6lrCiMKVcSSWAehIQQJCovI6UKXvECEgmUiJl3-1vbG_06kHVZW9uCmgY70oPNVJQAAAc5yuujHPKWyqw3dYvmkP29bAQ3R4C2wKYy447a_ruQqwQkFz-KV3aC</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>MAYLAND HAVELUND, Birgitte</creator><creator>BRANDT SØRENSEN, Flemming</creator><creator>LINDEBJERG, Jan</creator><creator>GARM SPINDLER, Karen-Lise</creator><creator>JAKOBSEN, Anders</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Pretreatment HIF-1α and GLUT-1 Expressions Do Not Correlate with Outcome after Preoperative Chemoradiotherapy in Rectal Cancer</title><author>MAYLAND HAVELUND, Birgitte ; BRANDT SØRENSEN, Flemming ; LINDEBJERG, Jan ; GARM SPINDLER, Karen-Lise ; JAKOBSEN, Anders</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-5470153c2ae865b334f40fb155fe47eb85ae3ab24ea0298bd688c1f1c0950e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Glucose Transporter Type 1 - metabolism</topic><topic>Humans</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</topic><topic>Immunoenzyme Techniques</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Preoperative Care</topic><topic>Rectal Neoplasms - metabolism</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - therapy</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAYLAND HAVELUND, Birgitte</creatorcontrib><creatorcontrib>BRANDT SØRENSEN, Flemming</creatorcontrib><creatorcontrib>LINDEBJERG, Jan</creatorcontrib><creatorcontrib>GARM SPINDLER, Karen-Lise</creatorcontrib><creatorcontrib>JAKOBSEN, Anders</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAYLAND HAVELUND, Birgitte</au><au>BRANDT SØRENSEN, Flemming</au><au>LINDEBJERG, Jan</au><au>GARM SPINDLER, Karen-Lise</au><au>JAKOBSEN, Anders</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pretreatment HIF-1α and GLUT-1 Expressions Do Not Correlate with Outcome after Preoperative Chemoradiotherapy in Rectal Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>31</volume><issue>5</issue><spage>1559</spage><epage>1565</epage><pages>1559-1565</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>The aim of the present study was to investigate hypoxia-inducible factor 1α (HIF-1α) and glucose transporter-1 (GLUT-1) expressions as predictors of response and survival after chemoradiotherapy in pretreatment biopsy specimens from patients with rectal cancer.
The immunohistological expressions of HIF-1α and GLUT-1 were investigated in pretreatment biopsies from 86 patients with rectal cancer receiving long course preoperative chemoradiotherapy. The immunohistological stainings were scored semi-quantitatively (percentage of stained cells and staining intensity), and an immunoreactive score was calculated. The response to the chemoradiotherapy was assessed by the Mandard Tumour Regression Grade system (TRG).
No association was found between HIF-1α or GLUT-1 and clinicopathological variables. HIF-1α and GLUT-1 expression had no predictive impact regarding response to chemoradiotherapy measured by TRG and was not associated with overall survival.
The present study did not suggest any predictive or prognostic value of pretreatment HIF-1α or GLUT-1 expression in patients with rectal cancer treated with preoperative chemoradiotherapy.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>21617210</pmid><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-7005 |
| ispartof | Anticancer research, 2011-05, Vol.31 (5), p.1559-1565 |
| issn | 0250-7005 1791-7530 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_869000105 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Combined Modality Therapy Female Gastroenterology. Liver. Pancreas. Abdomen Glucose Transporter Type 1 - metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunoenzyme Techniques Lymphatic Metastasis Male Medical sciences Middle Aged Neoplasm Staging Preoperative Care Rectal Neoplasms - metabolism Rectal Neoplasms - pathology Rectal Neoplasms - therapy Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Rate Treatment Outcome Tumors |
| title | Pretreatment HIF-1α and GLUT-1 Expressions Do Not Correlate with Outcome after Preoperative Chemoradiotherapy in Rectal Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T15%3A16%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pretreatment%20HIF-1%CE%B1%20and%20GLUT-1%20Expressions%20Do%20Not%20Correlate%20with%20Outcome%20after%20Preoperative%20Chemoradiotherapy%20in%20Rectal%20Cancer&rft.jtitle=Anticancer%20research&rft.au=MAYLAND%20HAVELUND,%20Birgitte&rft.date=2011-05-01&rft.volume=31&rft.issue=5&rft.spage=1559&rft.epage=1565&rft.pages=1559-1565&rft.issn=0250-7005&rft.eissn=1791-7530&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E869000105%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=869000105&rft_id=info:pmid/21617210&rfr_iscdi=true |