Photopigments in Central Serous Chorioretinopathy
Purpose To investigate functional abnormalities in eyes with central serous chorioretinopathy (CSC). Design Observational case series. Methods Sixteen eyes with CSC were enrolled. Autofluorescence densitometry was performed to measure the optical density of the photopigments. Serial fundus autofluor...
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| Veröffentlicht in: | American journal of ophthalmology 2011-06, Vol.151 (6), p.940-952.e1 |
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| creator | Ojima, Akira Iida, Tomohiro Sekiryu, Tetsuju Maruko, Ichiro Sugano, Yukinori |
| description | Purpose To investigate functional abnormalities in eyes with central serous chorioretinopathy (CSC). Design Observational case series. Methods Sixteen eyes with CSC were enrolled. Autofluorescence densitometry was performed to measure the optical density of the photopigments. Serial fundus autofluorescence (FAF) images were obtained by Heidelberg Retina Angiogram 2. We calculated the autofluorescence optical density difference from the FAF images. To compare the distribution pattern of autofluorescence optical density difference to the findings of outer retina, spectral-domain optical coherence tomography (SD-OCT) was performed in the acute phase and after resolution of CSC. Results The autofluorescence optical density difference decreased at the serous retinal detachment (SRD) in all 16 eyes. After resolution, the photoreceptor inner and outer segment junction (IS/OS) was irregular in 13 eyes and defective in 3 eyes on SD-OCT. The autofluorescence optical density difference did not improve in any eyes. Five eyes were reexamined 3 month after resolution. In 4 of the 5 eyes, SD-OCT showed that the IS/OS was well delineated and 1 eye defective. The autofluorescence optical density difference improved in 2 of the 4 eyes, but not in the other 2 eyes. In the 1 eye without well-delineated IS/OS, the autofluorescence optical density difference did not improve. Conclusion In eyes with CSC, the photopigment density decreased at the SRD. The density remained decreased immediately after resolution and showed delayed recovery. The photopigments decreased even in eyes with morphologic recovery of the outer retina. |
| doi_str_mv | 10.1016/j.ajo.2010.12.005 |
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Design Observational case series. Methods Sixteen eyes with CSC were enrolled. Autofluorescence densitometry was performed to measure the optical density of the photopigments. Serial fundus autofluorescence (FAF) images were obtained by Heidelberg Retina Angiogram 2. We calculated the autofluorescence optical density difference from the FAF images. To compare the distribution pattern of autofluorescence optical density difference to the findings of outer retina, spectral-domain optical coherence tomography (SD-OCT) was performed in the acute phase and after resolution of CSC. Results The autofluorescence optical density difference decreased at the serous retinal detachment (SRD) in all 16 eyes. After resolution, the photoreceptor inner and outer segment junction (IS/OS) was irregular in 13 eyes and defective in 3 eyes on SD-OCT. The autofluorescence optical density difference did not improve in any eyes. Five eyes were reexamined 3 month after resolution. In 4 of the 5 eyes, SD-OCT showed that the IS/OS was well delineated and 1 eye defective. The autofluorescence optical density difference improved in 2 of the 4 eyes, but not in the other 2 eyes. In the 1 eye without well-delineated IS/OS, the autofluorescence optical density difference did not improve. Conclusion In eyes with CSC, the photopigment density decreased at the SRD. The density remained decreased immediately after resolution and showed delayed recovery. The photopigments decreased even in eyes with morphologic recovery of the outer retina.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2010.12.005</identifier><identifier>PMID: 21457927</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Disease ; Adult ; Aged ; Biological and medical sciences ; Central Serous Chorioretinopathy - metabolism ; Central Serous Chorioretinopathy - physiopathology ; Central Serous Chorioretinopathy - surgery ; Comparative analysis ; Densitometry ; Female ; Fluorescein Angiography ; Humans ; Laser Coagulation ; Lasers ; Macular degeneration ; Male ; Medical imaging ; Medical sciences ; Middle Aged ; Miscellaneous ; Ophthalmology ; Photoreceptor Cells, Vertebrate - physiology ; Retina ; Retinal Detachment - metabolism ; Retinal Detachment - physiopathology ; Retinal Detachment - surgery ; Retinal Pigments - metabolism ; Retinopathies ; Studies ; Tomography, Optical Coherence ; Visual Acuity - physiology</subject><ispartof>American journal of ophthalmology, 2011-06, Vol.151 (6), p.940-952.e1</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-8629e307d56cf2724f7f0e35c297ff791a6cc302ad5b2dcf0d8ce4a5cc16c9013</citedby><cites>FETCH-LOGICAL-c465t-8629e307d56cf2724f7f0e35c297ff791a6cc302ad5b2dcf0d8ce4a5cc16c9013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000293941100002X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24219096$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21457927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ojima, Akira</creatorcontrib><creatorcontrib>Iida, Tomohiro</creatorcontrib><creatorcontrib>Sekiryu, Tetsuju</creatorcontrib><creatorcontrib>Maruko, Ichiro</creatorcontrib><creatorcontrib>Sugano, Yukinori</creatorcontrib><title>Photopigments in Central Serous Chorioretinopathy</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Purpose To investigate functional abnormalities in eyes with central serous chorioretinopathy (CSC). Design Observational case series. Methods Sixteen eyes with CSC were enrolled. Autofluorescence densitometry was performed to measure the optical density of the photopigments. Serial fundus autofluorescence (FAF) images were obtained by Heidelberg Retina Angiogram 2. We calculated the autofluorescence optical density difference from the FAF images. To compare the distribution pattern of autofluorescence optical density difference to the findings of outer retina, spectral-domain optical coherence tomography (SD-OCT) was performed in the acute phase and after resolution of CSC. Results The autofluorescence optical density difference decreased at the serous retinal detachment (SRD) in all 16 eyes. After resolution, the photoreceptor inner and outer segment junction (IS/OS) was irregular in 13 eyes and defective in 3 eyes on SD-OCT. The autofluorescence optical density difference did not improve in any eyes. Five eyes were reexamined 3 month after resolution. In 4 of the 5 eyes, SD-OCT showed that the IS/OS was well delineated and 1 eye defective. The autofluorescence optical density difference improved in 2 of the 4 eyes, but not in the other 2 eyes. In the 1 eye without well-delineated IS/OS, the autofluorescence optical density difference did not improve. Conclusion In eyes with CSC, the photopigment density decreased at the SRD. The density remained decreased immediately after resolution and showed delayed recovery. The photopigments decreased even in eyes with morphologic recovery of the outer retina.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Central Serous Chorioretinopathy - metabolism</subject><subject>Central Serous Chorioretinopathy - physiopathology</subject><subject>Central Serous Chorioretinopathy - surgery</subject><subject>Comparative analysis</subject><subject>Densitometry</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Laser Coagulation</subject><subject>Lasers</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Photoreceptor Cells, Vertebrate - physiology</subject><subject>Retina</subject><subject>Retinal Detachment - metabolism</subject><subject>Retinal Detachment - physiopathology</subject><subject>Retinal Detachment - surgery</subject><subject>Retinal Pigments - metabolism</subject><subject>Retinopathies</subject><subject>Studies</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity - physiology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-LFDEQxYO4uOPqB_AiAyKeejaV7iQdBEEG_ywsrLAK3kK2uuKk7emMSY8w3940M7qwB0-pgt-rvHrF2AvgK-CgLvuV6-NK8LkXK87lI7aAVpsKWgOP2YJzLipTm-acPc25L63SjX7CzgU0UhuhFwy-bOIUd-HHlsYpL8O4XJciuWF5Synu83K9iSnERFMY485Nm8MzdubdkOn56b1g3z5--Lr-XF3ffLpav7-usFFyqlolDNVcd1KhF1o0XntOtURhtPfagFOINReuk3eiQ8-7FqlxEhEUGg71BXtznLtL8dee8mS3ISMNgxupGLOtao0xTa0K-eoB2cd9Gos5C7xWsgUjTaHgSGGKOSfydpfC1qVDgewcp-1tidPOcVoQtsRZNC9Pk_d3W-r-Kf7mV4DXJ8BldINPbsSQ77lGgOFmtvj2yFFJ7HegZDMGGpG6kAgn28XwXxvvHqhxCGMoH_6kA-X7bW0uAns7330-OwCfy-_1H4nopdc</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Ojima, Akira</creator><creator>Iida, Tomohiro</creator><creator>Sekiryu, Tetsuju</creator><creator>Maruko, Ichiro</creator><creator>Sugano, Yukinori</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Photopigments in Central Serous Chorioretinopathy</title><author>Ojima, Akira ; Iida, Tomohiro ; Sekiryu, Tetsuju ; Maruko, Ichiro ; Sugano, Yukinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-8629e307d56cf2724f7f0e35c297ff791a6cc302ad5b2dcf0d8ce4a5cc16c9013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Central Serous Chorioretinopathy - metabolism</topic><topic>Central Serous Chorioretinopathy - physiopathology</topic><topic>Central Serous Chorioretinopathy - surgery</topic><topic>Comparative analysis</topic><topic>Densitometry</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Laser Coagulation</topic><topic>Lasers</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Photoreceptor Cells, Vertebrate - physiology</topic><topic>Retina</topic><topic>Retinal Detachment - metabolism</topic><topic>Retinal Detachment - physiopathology</topic><topic>Retinal Detachment - surgery</topic><topic>Retinal Pigments - metabolism</topic><topic>Retinopathies</topic><topic>Studies</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ojima, Akira</creatorcontrib><creatorcontrib>Iida, Tomohiro</creatorcontrib><creatorcontrib>Sekiryu, Tetsuju</creatorcontrib><creatorcontrib>Maruko, Ichiro</creatorcontrib><creatorcontrib>Sugano, Yukinori</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ojima, Akira</au><au>Iida, Tomohiro</au><au>Sekiryu, Tetsuju</au><au>Maruko, Ichiro</au><au>Sugano, Yukinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photopigments in Central Serous Chorioretinopathy</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>151</volume><issue>6</issue><spage>940</spage><epage>952.e1</epage><pages>940-952.e1</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>Purpose To investigate functional abnormalities in eyes with central serous chorioretinopathy (CSC). Design Observational case series. Methods Sixteen eyes with CSC were enrolled. Autofluorescence densitometry was performed to measure the optical density of the photopigments. Serial fundus autofluorescence (FAF) images were obtained by Heidelberg Retina Angiogram 2. We calculated the autofluorescence optical density difference from the FAF images. To compare the distribution pattern of autofluorescence optical density difference to the findings of outer retina, spectral-domain optical coherence tomography (SD-OCT) was performed in the acute phase and after resolution of CSC. Results The autofluorescence optical density difference decreased at the serous retinal detachment (SRD) in all 16 eyes. After resolution, the photoreceptor inner and outer segment junction (IS/OS) was irregular in 13 eyes and defective in 3 eyes on SD-OCT. The autofluorescence optical density difference did not improve in any eyes. Five eyes were reexamined 3 month after resolution. In 4 of the 5 eyes, SD-OCT showed that the IS/OS was well delineated and 1 eye defective. The autofluorescence optical density difference improved in 2 of the 4 eyes, but not in the other 2 eyes. In the 1 eye without well-delineated IS/OS, the autofluorescence optical density difference did not improve. Conclusion In eyes with CSC, the photopigment density decreased at the SRD. The density remained decreased immediately after resolution and showed delayed recovery. The photopigments decreased even in eyes with morphologic recovery of the outer retina.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21457927</pmid><doi>10.1016/j.ajo.2010.12.005</doi><tpages>13</tpages></addata></record> |
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| subjects | Acute Disease Adult Aged Biological and medical sciences Central Serous Chorioretinopathy - metabolism Central Serous Chorioretinopathy - physiopathology Central Serous Chorioretinopathy - surgery Comparative analysis Densitometry Female Fluorescein Angiography Humans Laser Coagulation Lasers Macular degeneration Male Medical imaging Medical sciences Middle Aged Miscellaneous Ophthalmology Photoreceptor Cells, Vertebrate - physiology Retina Retinal Detachment - metabolism Retinal Detachment - physiopathology Retinal Detachment - surgery Retinal Pigments - metabolism Retinopathies Studies Tomography, Optical Coherence Visual Acuity - physiology |
| title | Photopigments in Central Serous Chorioretinopathy |
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