Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field

Abstract Congenital heart defects (CHDs) occur in 0.5–1% of live births, yet the underlying genetic etiology remains mostly unknown. Recently, a new source of myocardial cells, namely the second heart field (SHF), was discovered in the splanchnic mesoderm. Abnormal development of the SHF leads to a...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2011-07, Vol.51 (1), p.58-66
Hauptverfasser:	Nakazawa, Maki, Uchida, Keiko, Aramaki, Megumi, Kodo, Kazuki, Yamagishi, Chihiro, Takahashi, Takao, Mikoshiba, Katsuhiko, Yamagishi, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Ca 2+ channel Ca 2+ signaling Calcium Signaling Cardiovascular Congenital heart defect DNA-Binding Proteins - metabolism Endoplasmic Reticulum - metabolism Gene Expression Profiling Heart - embryology Heart Defects, Congenital - etiology Heart development Heart Ventricles - abnormalities In Situ Hybridization In Situ Nick-End Labeling Inositol 1,4,5-Trisphosphate - metabolism Inositol 1,4,5-Trisphosphate Receptors - genetics Inositol 1,4,5-Trisphosphate Receptors - metabolism MEF2 Transcription Factors Mice Mice, Knockout Microarray Analysis Muscle Proteins - metabolism Myogenic Regulatory Factors - metabolism Outflow tract Sarcoplasmic Reticulum - metabolism Transcription Factors - metabolism
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