Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice

Mutations of the ATRX gene, which encodes an ATP‐dependent chromatin‐remodeling factor, were identified in patients with α‐thalassemia X‐linked mental retardation (ATR‐X) syndrome. There is a milder variant of ATR‐X syndrome caused by mutations in the Exon 2 of the gene. To examine the impact of the...

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Veröffentlicht in:	Hippocampus 2011-06, Vol.21 (6), p.678-687
Hauptverfasser:	Nogami, Tatsuya, Beppu, Hideyuki, Tokoro, Takashi, Moriguchi, Shigeki, Shioda, Norifumi, Fukunaga, Kohji, Ohtsuka, Toshihisa, Ishii, Yoko, Sasahara, Masakiyo, Shimada, Yutaka, Nishijo, Hisao, Li, En, Kitajima, Isao
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Thalassemia - genetics alpha-Thalassemia - metabolism Animals ATRX CA1 Region, Hippocampal - metabolism CA1 Region, Hippocampal - physiopathology Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism CaMKII Conditioning, Classical - physiology Disease Models, Animal DNA Helicases - genetics DNA Helicases - metabolism Exons - genetics Fear - physiology Fear - psychology Freezing Reaction, Cataleptic - physiology GluR1 Humans learning Learning Disorders - genetics Long-Term Potentiation - genetics Long-Term Potentiation - physiology Maze Learning - physiology Mental Retardation, X-Linked - genetics Mental Retardation, X-Linked - metabolism Mice Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphorylation Receptors, AMPA - metabolism X-linked Nuclear Protein
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