Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors

Vascular adhesion protein-1 (VAP-1) belongs to a family of amine oxidases. It plays a role in leukocyte trafficking and in amine compound metabolism. VAP-1 is linked to various diseases, such as Alzheimer’s disease, psoriasis, depression, diabetes, and obesity. Accordingly, selective inhibitors of V...

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Veröffentlicht in:	Journal of medicinal chemistry 2011-04, Vol.54 (7), p.2143-2154
Hauptverfasser:	Nurminen, Elisa M, Pihlavisto, Marjo, Lázár, László, Pentikäinen, Ulla, Fülöp, Ferenc, Pentikäinen, Olli T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amine Oxidase (Copper-Containing) - antagonists & inhibitors Amine Oxidase (Copper-Containing) - chemistry Amine Oxidase (Copper-Containing) - metabolism Animals Binding Sites Cell Adhesion Molecules - antagonists & inhibitors Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism CHO Cells Cricetinae Cricetulus Humans Hydrazines - chemical synthesis Hydrazines - chemistry Hydrazines - metabolism Hydrazines - pharmacology Ligands Molecular Dynamics Simulation Monoamine Oxidase - chemistry Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - chemical synthesis Monoamine Oxidase Inhibitors - chemistry Monoamine Oxidase Inhibitors - metabolism Monoamine Oxidase Inhibitors - pharmacology Protein Conformation Rats Structure-Activity Relationship Substrate Specificity
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