Ghrelin Inhibits Hydrogen Peroxide-Induced Apoptotic Cell Death of Oligodendrocytes Via ERK and p38MAPK Signaling

H2O2-induced apoptotic cell death of oligodendrocytes is significantly inhibited by ghrelin through increasing ERK activation and decreasing p38MAPK activation, which is dependent on ghrelin receptor. Here, we examined the protective effect of ghrelin on apoptotic cell death induced by hydrogen pero...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2011-06, Vol.152 (6), p.2377-2386
Hauptverfasser:	Lee, Jee Y, Oh, Tae H, Yune, Tae Y
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Apoptosis Apoptosis - drug effects Biological and medical sciences c-Jun protein Caspase-3 Cell activation Cell death Cell survival Cells, Cultured Central nervous system Cytochrome c Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Fundamental and applied biological sciences. Psychology Ghrelin Ghrelin - metabolism Growth hormones Hydrogen peroxide Hydrogen Peroxide - toxicity JNK protein Kinases MAP Kinase Signaling System - drug effects Mortality Oligodendrocytes Oligodendroglia - cytology Oligodendroglia - drug effects Oligodendroglia - enzymology Oligodendroglia - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Pharmacology Protective Agents - metabolism Rats Rats, Sprague-Dawley Receptors Transcription factors Vertebrates: endocrinology
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