Determination of a dipeptidyl peptidase IV agonist, β-aminoacyl containing thiazolidine derivatives (KR-66223) in rat plasma by liquid chromatography–tandem mass spectrometry

A sensitive liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed for a novel dipeptidyl peptidase IV agonist (DDP-IV) agonist, KR-66223, in rat plasma. It involves liquid-liquid extraction (LLE) followed by HPLC separation and electrospray ionization tandem mass spectrometr...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2011-07, Vol.55 (5), p.1083-1088, Article 1083
Hauptverfasser:	Kim, Min-Sun, Park, Jong-Shik, Jang, Su-Min, Lee, Byung Hoi, Ahn, Sung-Hoon, Ahn, Jin Hee, Yoo, Sung Eun, Song, Im-Sook, Silinski, Peter, Schneider, Stephen Edward, Bae, Myung Ae
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitriles - chemistry agonists Aminobutyrates - blood Aminobutyrates - chemistry Analysis Analytical, structural and metabolic biochemistry Animals Area Under Curve Biological and medical sciences Blood Proteins - chemistry Calibration Chromatography, Liquid - methods correlation Dipeptidyl Peptidase 4 - agonists dipeptidyl-peptidase IV Formates - chemistry Fundamental and applied biological sciences. Psychology General pharmacology high performance liquid chromatography Imipramine - chemistry ionization KR-66223 LC/MS/MS liquid-liquid extraction Male Medical sciences Method validation monitoring Pharmacokinetics Pharmacology. Drug treatments Rat plasma Rats Rats, Sprague-Dawley Reproducibility of Results tandem mass spectrometry Tandem Mass Spectrometry - methods Thiazolidines - blood Thiazolidines - chemistry Valine - analogs & derivatives
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